The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways

Smad4-mediated TGF-β signaling in tumorigenesis

(2012) Guan Yang et al.   International Journal of Biological Sciences

The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms

(2011) Zaklina Kovacevic et al.   CARCINOGENESIS

Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer

(2011) Z. Kovacevic et al.   MOLECULAR PHARMACOLOGY

The p85β regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling

(2010) Jiman He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells

(2010) Yuichi Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGFβ modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells

(2010) Jimmy Y.C. Chow et al.   CANCER BIOLOGY & THERAPY

TGF-β downregulates PTEN via activation of NF-κB in pancreatic cancer cells

(2009) Jimmy Y. C. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of  B Kinase   Expression

(2009) F. Hosoi et al.   CANCER RESEARCH

Post-transcriptional and post-translational regulation of PTEN by transforming growth factor-β1

(2009) Yong Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

TGF-β mediates PTEN suppression and cell motility through calcium-dependent PKC-α activation in pancreatic cancer cells

(2008) Jimmy Y. C. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia

(2008) X.Y. Hu et al.   EJSO

Akt as a therapeutic target in cancer

(2008) Linda S Steelman et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

New Therapeutic Directions for Advanced Pancreatic Cancer: Targeting the Epidermal Growth Factor and Vascular Endothelial Growth Factor Pathways

(2008) H. Burris et al.   ONCOLOGIST