Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells

N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis

(2012) Wen Liu et al.   EMBO Molecular Medicine

The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1)

(2012) Zhiqiang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How can food extracts consumed in the Mediterranean and East Asia suppress prostate cancer proliferation?

(2011) Mu Yao et al.   BRITISH JOURNAL OF NUTRITION

Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy

(2011) Y Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ironing Out Cancer

(2011) S. V. Torti et al.   CANCER RESEARCH

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms

(2011) Zaklina Kovacevic et al.   CARCINOGENESIS

Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer

(2011) Z. Kovacevic et al.   MOLECULAR PHARMACOLOGY

Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells

(2010) Yuichi Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting prostate cancer based on signal transduction and cell cycle pathways

(2010) John T. Lee et al.   CELL CYCLE

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase II  in Breast Cancer Cells

(2009) V. A. Rao et al.   CANCER RESEARCH

The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1

(2009) Junko H. Ohyashiki et al.   CANCER SCIENCE

Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells

(2008) Egarit Noulsri et al.   AMERICAN JOURNAL OF HEMATOLOGY

Iron Depletion by Deferoxamine Up-Regulates Glucose Uptake and Insulin Signaling in Hepatoma Cells and in Rat Liver

(2008) Paola Dongiovanni et al.   AMERICAN JOURNAL OF PATHOLOGY

The TGF-β, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer

(2008) Stephen J. Assinder et al.   BIOCHEMICAL JOURNAL

Signaling and apoptosis differences between severe hypoxia and desferoxamine treatment of human epithelial cells

(2008) Adrian Harold Box et al.   Biochemistry and Cell Biology

Pharmacological Targeting of the Integrated Protein Kinase B, Phosphatase and Tensin Homolog Deleted on Chromosome 10, and Transforming Growth Factor-  Pathways in Prostate Cancer

(2008) S. J. Assinder et al.   MOLECULAR PHARMACOLOGY