Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma

Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin

(2021) Ramesh B. Kasetti et al.   JCI Insight

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

(2021) Guorong Li et al.   eLife

Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9

(2021) Prabhavathi Maddineni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR inhibitors potentially reduce TGF-β2-induced fibrogenic changes in trabecular meshwork cells

(2021) Nozomi Igarashi et al.   Scientific Reports

Nuclear factor-kappa beta signaling is required for transforming growth factor Beta-2 induced ocular hypertension

(2020) Humberto Hernandez et al.   EXPERIMENTAL EYE RESEARCH

Astragaloside IV suppresses inflammatory response via suppression of NF-κB, and MAPK signalling in human bronchial epithelial cells

(2020) Hsi-Lung Hsieh et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Treatment of glaucoma by prostaglandin agonists and beta‐blockers in combination directly reduces pro‐fibrotic gene expression in trabecular meshwork

(2020) Sushma Tejwani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork

(2020) Ramesh B. Kasetti et al.   PLoS One

Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1/Smad Signaling Pathway

(2018) Xingxing Yuan et al.   Evidence-based Complementary and Alternative Medicine

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

(2018) Kate E. Keller et al.   EXPERIMENTAL EYE RESEARCH

Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension

(2018) Ramesh B. Kasetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats

(2018) Yinghui Ju et al.   BIOMEDICINE & PHARMACOTHERAPY

Cross-linked actin networks (CLANs) in glaucoma

(2017) Jaclyn Y. Bermudez et al.   EXPERIMENTAL EYE RESEARCH

Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro

(2017) Xiangjun Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CRISPR-Cas9–based treatment of myocilin-associated glaucoma

(2017) Ankur Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy

(2017) Hengjiang Guo et al.   Scientific Reports

Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork

(2017) Ramesh B. Kasetti et al.   Scientific Reports

Research review on the pharmacological effects of astragaloside IV

(2016) Lei Li et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor

(2016) Karen Y. Torrejon et al.   Scientific Reports

Astragaloside IV suppresses transforming growth factor-β1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-κB signaling pathways

(2015) Xiajing Che et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium

(2015) Yan Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

(2015) Wei-Jian Zhang et al.   MEDIATORS OF INFLAMMATION

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

(2014) Yifang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro

(2014) Li Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

(2014) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice

(2013) Colleen M. McDowell et al.   EXPERIMENTAL EYE RESEARCH

Epithelial mesenchymal transition-like phenomenon in trabecular meshwork cells

(2013) Eri Takahashi et al.   EXPERIMENTAL EYE RESEARCH

Effects of Prostaglandin Analogues on Aqueous Humor Outflow Pathways

(2013) Nelson S. Winkler et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers

(2013) Meijuan Xu et al.   PHYTOMEDICINE

Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β Responses

(2012) Swati Bhattacharyya et al.   AMERICAN JOURNAL OF PATHOLOGY

Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy

(2011) Ping Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2011) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells

(2009) Padmanabhan P. Pattabiraman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The trabecular meshwork outflow pathways: Structural and functional aspects

(2009) Ernst R. Tamm   EXPERIMENTAL EYE RESEARCH

Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-β Signaling

(2009) Xiaohua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells

(2009) Hao Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Primary Open-Angle Glaucoma

(2009) Young H. Kwon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular matrix in the trabecular meshwork

(2008) Ted S. Acott et al.   EXPERIMENTAL EYE RESEARCH

Extracellular matrix turnover and outflow resistance

(2008) Kate E. Keller et al.   EXPERIMENTAL EYE RESEARCH