Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9

Steroid Induced Glaucoma: epidemiology, pathophysiology and clinical management

(2020) Gloria Roberti et al.   SURVEY OF OPHTHALMOLOGY

Matrix Metalloproteinases and Glaucoma Treatment

(2020) Robert N. Weinreb et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

(2020) Prabhavathi Maddineni et al.   Molecular Neurodegeneration

In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model

(2019) Guorong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of MCP-1 and MMP-9 in aqueous humor is associated with secondary glaucoma in Fuchs uveitis syndrome

(2019) D. Bauer et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Increased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyes

(2019) Amir Vahabikashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

(2018) Vijay Krishna Raghunathan et al.   Acta Biomaterialia

Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension

(2018) Ramesh B. Kasetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic association of -1562C>T polymorphism in the MMP9 gene with primary glaucoma in a north Indian population

(2018) Nanamika Thakur et al.   PLoS One

Trabecular meshwork stiffness in glaucoma

(2017) Ke Wang et al.   EXPERIMENTAL EYE RESEARCH

The many faces of the trabecular meshwork cell

(2017) W. Daniel Stamer et al.   EXPERIMENTAL EYE RESEARCH

DEX implant intravitreal injection, sustained intraocular hypertension, and steroid-induced glaucoma in patients with no risk factors

(2017) Amina Rezkallah et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma

(2017) Jeffrey O’Callaghan et al.   HUMAN MOLECULAR GENETICS

The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9

(2017) Pilar Sánchez-Blázquez et al.   MOLECULAR NEUROBIOLOGY

Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork

(2017) Ramesh B. Kasetti et al.   Scientific Reports

Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma

(2016) Tianjing Li et al.   OPHTHALMOLOGY

Animal models of glucocorticoid-induced glaucoma

(2015) Darryl R. Overby et al.   EXPERIMENTAL EYE RESEARCH

Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma

(2015) Janice A. Vranka et al.   EXPERIMENTAL EYE RESEARCH

Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

(2014) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma - a quantitative study

(2014) Angeline DC Nga et al.   BMC Ophthalmology

Matrix Metalloproteinase-9: Many Shades of Function in Cardiovascular Disease

(2013) Andriy Yabluchanskiy et al.   PHYSIOLOGY

Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: Safety, pharmacokinetics and ammonia control

(2010) Brendan Lee et al.   MOLECULAR GENETICS AND METABOLISM

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

The role of steroids in outflow resistance

(2008) Abbot F. Clark et al.   EXPERIMENTAL EYE RESEARCH