Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin

Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork

(2020) Ramesh B. Kasetti et al.   PLoS One

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

(2020) Prabhavathi Maddineni et al.   Molecular Neurodegeneration

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

(2018) Kate E. Keller et al.   EXPERIMENTAL EYE RESEARCH

Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension

(2018) Ramesh B. Kasetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The many faces of the trabecular meshwork cell

(2017) W. Daniel Stamer et al.   EXPERIMENTAL EYE RESEARCH

Transcription Factor C/EBP Homologous Protein in Health and Diseases

(2017) Yuan Yang et al.   Frontiers in Immunology

Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork

(2017) Ramesh B. Kasetti et al.   Scientific Reports

Autophagic dysregulation in glaucomatous trabecular meshwork cells

(2015) Kristine Porter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis

(2015) Venediktos V Kapetanakis et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Elevation of intraocular pressure in rodents using viral vectors targeting the trabecular meshwork

(2015) Iok-Hou Pang et al.   EXPERIMENTAL EYE RESEARCH

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2015) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

(2014) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Processing of Myocilin

(2014) Ye Qiu et al.   PLoS One

Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

(2013) M. Sandri et al.   JOURNAL OF CELL SCIENCE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Autophagy in Human Health and Disease

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response

(2013) Robert R.H. Anholt et al.   TRENDS IN MOLECULAR MEDICINE

Prevalence of Glaucoma in an Urban West African Population

(2013) Donald L. Budenz et al.   JAMA Ophthalmology

Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression

(2013) H. Matsumoto et al.   Biology Open

Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice

(2012) Colleen M. McDowell et al.   EXPERIMENTAL EYE RESEARCH

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

(2012) Amirthaa Suntharalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blindness and Visual Impairment in an Urban West African Population: The Tema Eye Survey

(2012) Donald L. Budenz et al.   OPHTHALMOLOGY

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2011) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

(2011) Qingsong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Autophagy in cellular growth control

(2010) Richard C. Wang et al.   FEBS LETTERS

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Targeted Mutation of the Mouse Grp94 Gene Disrupts Development and Perturbs Endoplasmic Reticulum Stress Signaling

(2010) Changhui Mao et al.   PLoS One

Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress

(2009) Yoshihito Ishida et al.   Autophagy

Primary Open-Angle Glaucoma

(2009) Young H. Kwon et al.   NEW ENGLAND JOURNAL OF MEDICINE

The genetics of primary open-angle glaucoma: A review

(2008) R. Rand Allingham et al.   EXPERIMENTAL EYE RESEARCH