Neutrophils, Cancer and Thrombosis: The New Bermuda Triangle in Cancer Research

IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions

(2021) Gianluca Mucciolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer

(2021) Axel Rosell et al.   Scientific Reports

Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands

(2021) Shuvasree SenGupta et al.   Frontiers in Immunology

DNAse-dependent, NET-independent pathway of thrombus formation in vivo

(2021) Estelle Carminita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2RY12-Inhibitors Reduce Cancer-Associated Thrombosis and Tumor Growth in Pancreatic Cancers

(2021) Ana Luisa Palacios-Acedo et al.   Frontiers in Oncology

Modulation of Cellular NAD+ Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps

(2021) Wa Cao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

(2020) Aoife M. McGinley et al.   IMMUNITY

Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells

(2020) Omar Elaskalani et al.   Cancers

Extracellular Vesicles From Gastric Cancer Cells Induce PD-L1 Expression on Neutrophils to Suppress T-Cell Immunity

(2020) Yinghong Shi et al.   Frontiers in Oncology

Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate

(2020) Emma Nolan et al.   NATURE

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

(2020) Linbin Yang et al.   NATURE

Diagnostic, Therapeutic Predictive, and Prognostic Value of Neutrophil Extracellular Traps in Patients With Gastric Adenocarcinoma

(2020) Yiyin Zhang et al.   Frontiers in Oncology

Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance

(2020) Charita Furumaya et al.   Frontiers in Immunology

Update on Guidelines for the Management of Cancer‐Associated Thrombosis

(2020) Michael B. Streiff et al.   ONCOLOGIST

Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells

(2019) Sen Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Neutrophils: back in the thrombosis spotlight

(2019) Denis F. Noubouossie et al.   BLOOD

Neutrophils and NETS in modulating acute and chronic inflammation

(2019) Fernanda Vargas e Silva Castanheira et al.   BLOOD

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors

(2019) Yohei Hisada et al.   HAEMATOLOGICA

Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines

(2019) Marco Antonio Cassatella et al.   TRENDS IN IMMUNOLOGY

Neutrophil Extracellular Traps

(2019) Charlotte Thålin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

(2019) Yuxin Lin et al.   Journal of Hematology & Oncology

Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy

(2019) Ana Luisa Palacios-Acedo et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth

(2019) Hamza O Yazdani et al.   CANCER RESEARCH

Neutrophils promote tumor resistance to radiation therapy

(2019) Amy J. Wisdom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Heterogeneity in Cancer: From Biology to Therapies

(2019) Pacôme Lecot et al.   Frontiers in Immunology

The interaction of platelets with colorectal cancer cells inhibits tumor growth but promotes metastasis

(2019) Léa Plantureux et al.   CANCER RESEARCH

ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12

(2019) Loreen Kloss et al.   Cell Death & Disease

Neutrophils suppress tumor‐infiltrating T cells in colon cancer via matrix metalloproteinase‐mediated activation of TGF β

(2019) Markus Germann et al.   EMBO Molecular Medicine

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

(2018) Xiaohong Ruby Xu et al.   BLOOD

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

(2018) Brian A. Boone et al.   BMC CANCER

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones

(2018) Omar Elaskalani et al.   Cell Communication and Signaling

Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients

(2018) L.-M. Mauracher et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effects of platelets on cancer progression

(2018) Léa Plantureux et al.   THROMBOSIS RESEARCH

Neutrophilia as prognostic biomarker in locally advanced stage III lung cancer

(2018) Antoine Schernberg et al.   PLoS One

The role of neutrophils in thrombosis

(2018) Sargam Kapoor et al.   THROMBOSIS RESEARCH

Inefficient N2-Like Neutrophils Are Promoted by Androgens During Infection

(2018) María V. Scalerandi et al.   Frontiers in Immunology

The role of coagulation and platelets in colon cancer-associated thrombosis.

(2018) Annachiara Mitrugno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of platelets and platelet receptors in cancer metastasis

(2018) Martin Schlesinger   Journal of Hematology & Oncology

Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration

(2018) Xu Zhang et al.   Molecular Cancer

Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases

(2018) Xu Wang et al.   Frontiers in Immunology

Fibrin-bearing microparticles: marker of thrombo-embolic events in pancreatic and colorectal cancers

(2017) Diane Mege et al.   Oncotarget

IL-35 induces N2 phenotype of neutrophils to promote tumor growth

(2017) Jiu-Ming Zou et al.   Oncotarget

Leukocytosis and neutrophilia predict outcome in locally advanced esophageal cancer treated with definitive chemoradiation

(2017) Antoine Schernberg et al.   Oncotarget

Influence of Microbes on Neutrophil Life and Death

(2017) Scott D. Kobayashi et al.   Frontiers in Cellular and Infection Microbiology

Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab

(2016) P. F. Ferrucci et al.   ANNALS OF ONCOLOGY

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Interleukin-17–Producing Neutrophils Link Inflammatory Stimuli to Disease Progression by Promoting Angiogenesis in Gastric Cancer

(2016) Tuan-Jie Li et al.   CLINICAL CANCER RESEARCH

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

(2016) Susanne Pfeiler et al.   HAEMATOLOGICA

Granulopoiesis and granules of human neutrophils

(2016) Jack B. Cowland et al.   IMMUNOLOGICAL REVIEWS

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

(2016) Jaehong Kim et al.   MEDIATORS OF INFLAMMATION

Platelet phenotype changes associated with breast cancer and its treatment

(2016) Chris E. Holmes et al.   PLATELETS

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences

(2016) Soraya Mezouar et al.   THROMBOSIS RESEARCH

NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation

(2016) Charlotte Thålin et al.   THROMBOSIS RESEARCH

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

(2016) Damya Laoui et al.   Nature Communications

Tumour-associated circulating microparticles: A novel liquid biopsy tool for screening and therapy monitoring of colorectal carcinoma and other epithelial neoplasia

(2016) Arnulf Willms et al.   Oncotarget

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

(2016) Susanne Pfeiler et al.   HAEMATOLOGICA

Priming of neutrophils toward NETosis promotes tumor growth

(2016) Mélanie Demers et al.   OncoImmunology

Gradient Infiltration of Neutrophil Extracellular Traps in Colon Cancer and Evidence for Their Involvement in Tumour Growth

(2016) Stella Arelaki et al.   PLoS One

Platelets at the interface of thrombosis, inflammation, and cancer

(2015) A. T. Franco et al.   BLOOD

Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

(2015) Dimitrios A. Stakos et al.   EUROPEAN HEART JOURNAL

Trousseau's syndrome: cancer-associated thrombosis

(2015) Soichiro Ikushima et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Microparticles in cancer: A review of recent developments and the potential for clinical application

(2015) Joyce Gong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice

(2014) R. Darbousset et al.   BLOOD

Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

(2014) Thassila Pitanga et al.   BMC CELL BIOLOGY

Neutrophil extracellular traps in cancer progression

(2014) Jonathan Cools-Lartigue et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasisin vivo

(2014) Soraya Mezouar et al.   INTERNATIONAL JOURNAL OF CANCER

Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGF -1

(2014) N. D. L. Savage et al.   JOURNAL OF IMMUNOLOGY

Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis

(2014) Arnoud J. Templeton et al.   JNCI-Journal of the National Cancer Institute

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development

(2014) A. S. Savchenko et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microenvironnement tumoral

(2014) Mélanie Bruchard et al.   M S-MEDECINE SCIENCES

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

Involvement of Platelet-Derived Microparticles in Tumor Progression and Thrombosis

(2014) Soraya Mezouar et al.   SEMINARS IN ONCOLOGY

Epidemiology of cancer-associated venous thrombosis

(2013) J. F. Timp et al.   BLOOD

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones

(2013) Colin Longstaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of IL-17A in Tumor Microenvironment Augments Cytotoxicity of Tumor-Infiltrating Lymphocytes in Tumor-Bearing Mice

(2013) Keiji Hayata et al.   PLoS One

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  

(2012) A. M. McInturff et al.   BLOOD

Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation

(2012) R. Darbousset et al.   BLOOD

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coagulation and cancer: biological and clinical aspects

(2012) A. FALANGA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Hospitalisation for venous thromboembolism in cancer patients and the general population: a population-based cohort study in Denmark, 1997–2006

(2010) D P Cronin-Fenton et al.   BRITISH JOURNAL OF CANCER

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Factor in Coagulation

(2009) Saulius Butenas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow

(2009) U. Y. Schaff et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Expression, activation, and function of integrin  M 2 (Mac-1) on neutrophil-derived microparticles

(2008) E. Pluskota et al.   BLOOD