Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells

P2Y12 Receptors in Tumorigenesis and Metastasis

(2018) Patrizia Ballerini et al.   Frontiers in Pharmacology

Understanding the biology of HER3 receptor as a therapeutic target in human cancer

(2018) Hui Lyu et al.   Acta Pharmaceutica Sinica B

Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach

(2018) An Ning Cheng et al.   EBioMedicine

Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment

(2018) Norbaini Abdol Razak et al.   Cancers

Ticagrelor, but not clopidogrel active metabolite, displays antithrombotic properties in the left atrial endocardium

(2017) Martin F. Reiner et al.   EUROPEAN HEART JOURNAL

Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin

(2017) Thomas H. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Targeting Platelets for the Treatment of Cancer

(2017) Omar Elaskalani et al.   Cancers

The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance

(2017) Omar Elaskalani et al.   Cancers

Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor

(2016) R. Aungraheeta et al.   BLOOD

Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT)

(2016) A. S. Martínez-Ramírez et al.   Purinergic Signalling

Long-term survival in patients with pancreatic ductal adenocarcinoma

(2016) Alexander P. Stark et al.   SURGERY

Current State and Novel Approaches of Antiplatelet Therapy

(2015) P. Metharom et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Efficacy of Prophylactic Low–Molecular Weight Heparin for Ambulatory Patients With Advanced Pancreatic Cancer: Outcomes From the CONKO-004 Trial

(2015) Uwe Pelzer et al.   JOURNAL OF CLINICAL ONCOLOGY

P2Y12 Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus

(2015) Y. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages

(2015) Alessandra Rosati et al.   Nature Communications

P2Y2 receptor promotes cell invasion and metastasis in prostate cancer cells

(2013) W-H Li et al.   BRITISH JOURNAL OF CANCER

A pharmacokinetic interaction study of ticagrelor and digoxin in healthy volunteers

(2013) Renli Teng et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

ATP-Mediated Transactivation of the Epidermal Growth Factor Receptor in Airway Epithelial Cells Involves DUOX1-Dependent Oxidation of Src and ADAM17

(2013) Derek Sham et al.   PLoS One

P2Y12protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation

(2012) S. ZHANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of the pharmacokinetics and pharmacodynamics of ticagrelor co-administered with aspirin in healthy volunteers

(2012) Renli Teng et al.   PLATELETS

nab -Paclitaxel Potentiates Gemcitabine Activity by Reducing Cytidine Deaminase Levels in a Mouse Model of Pancreatic Cancer

(2012) Kristopher K. Frese et al.   Cancer Discovery

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

P2Y12 receptor in platelet activation

(2011) Soochong Kim et al.   PLATELETS

Ticagrelor Effectively and Reversibly Blocks Murine Platelet P2Y 12 -Mediated Thrombosis and Demonstrates a Requirement for Sustained P2Y 12 Inhibition to Prevent Subsequent Neointima

(2010) Shankar B. Patil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

P2Y2Nucleotide Receptors Mediate Metalloprotease-dependent Phosphorylation of Epidermal Growth Factor Receptor and ErbB3 in Human Salivary Gland Cells

(2010) Ann M. Ratchford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine A1 receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro

(2009) Ke-qiang Xie et al.   ACTA PHARMACOLOGICA SINICA

Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study

(2009) Giancarlo Agnelli et al.   LANCET ONCOLOGY

Studies on the role of the extracellular cysteines and oligomeric structures of the P2Y12receptor when interacting with antagonists

(2008) ZHONGREN DING et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

LY2109761, a novel transforming growth factor   receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

(2008) D. Melisi et al.   MOLECULAR CANCER THERAPEUTICS