Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice

Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives

(2022) Tatyana Strekalova et al.   PSYCHOPHARMACOLOGY

Effect of neuropsychiatric medications on mitochondrial function; for better or for worse

(2021) Tim L. Emmerzaal et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Increased Oxidative Stress in the Prefrontal Cortex as a Shared Feature of Depressive- and PTSD-Like Syndromes: Effects of a Standardized Herbal Antioxidant

(2021) Johannes de Munter et al.   Frontiers in Nutrition

The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD

(2021) Felipe Borges Almeida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Can FDA-Approved Immunomodulatory Drugs be Repurposed/Repositioned to Alleviate Chronic Pain?

(2021) Kufreobong E. Inyang et al.   Journal of Neuroimmune Pharmacology

Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme

(2021) Jaya Prabhakaran et al.   MOLECULES

Depression Induced by CUMS Leads to Bladder Cancer Development and Local Tumor Immunosuppression in Mice

(2021) Zhiyu Qian et al.   Journal of Oncology

Reproducible induction of depressive-like behavior in C57BL/6J mice exposed to chronic social defeat stress with a modified sensory contact protocol

(2021) Yusuke Kamimura et al.   LIFE SCIENCES

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

(2021) Xiao Zhang et al.   Nature Communications

Resilience, Cardiological Outcome, and Their Correlations With Anxious-Depressive Symptoms and Quality of Life in Patients With an Implantable Cardioverter Defibrillator

(2021) Celeste Isella et al.   Frontiers in Psychiatry

Therapeutic Strategies for Treatment-resistant Depression: State of the Art and Future Perspectives

(2020) Kah K. Goh et al.   CURRENT PHARMACEUTICAL DESIGN

Ultrasound stress compromises the correlates of emotional-like states and brain AMPAR expression in mice: effects of antioxidant and anti-inflammatory herbal treatment

(2020) João Pedro Costa-Nunes et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Neuroinflammation and depression: A review

(2020) Romain Troubat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects

(2020) Zhe-Hao Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors

(2020) Mario Gennaro Mazza et al.   BRAIN BEHAVIOR AND IMMUNITY

Blues in the Brain and Beyond: Molecular Bases of Major Depressive Disorder and Relative Pharmacological and Non-Pharmacological Treatments

(2020) Elisabetta Maffioletti et al.   Genes

Depression and inflammation among children and adolescents: A meta-analysis

(2020) Marlena Colasanto et al.   JOURNAL OF AFFECTIVE DISORDERS

Mental health impact of the first wave of COVID-19 pandemic on Spanish healthcare workers: A large cross-sectional survey

(2020) Jordi Alonso et al.   Revista de Psiquiatria y Salud Mental

Animal models of major depressive disorder and the implications for drug discovery and development

(2019) Konstantin A. Demin et al.   Expert Opinion on Drug Discovery

Neurobiology of Resilience: Interface Between Mind and Body

(2019) Flurin Cathomas et al.   BIOLOGICAL PSYCHIATRY

Selective serotonin reuptake inhibitors and benzodiazepines in panic disorder: A meta-analysis of common side effects in acute treatment

(2019) Laiana A Quagliato et al.   JOURNAL OF PSYCHOPHARMACOLOGY

COX-2 Inhibitors, Aspirin, and Other Potential Anti-Inflammatory Treatments for Psychiatric Disorders

(2019) Norbert Müller   Frontiers in Psychiatry

Neurobiology of resilience in depression: immune and vascular insights from human and animal studies

(2019) Katarzyna A. Dudek et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

(2019) Rickinder Sethi et al.   Frontiers in Psychiatry

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

(2019) Nataliya Gorinski et al.   Nature Communications

Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress

(2019) Min Tang et al.   Translational Psychiatry

Short- and Long-Term Antidepressant Clinical Trials for Major Depressive Disorder in Youth: Findings and Concerns

(2019) Daniel J. Safer et al.   Frontiers in Psychiatry

Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice

(2019) Ekaterina Veniaminova et al.   LIFE SCIENCES

COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats

(2019) Qiqi Song et al.   NEUROPHARMACOLOGY

Current Therapeutic Approaches for Targeting Inflammation in Depression and Cardiovascular Disease

(2018) Pedro Zuzarte et al.   CURRENT DRUG METABOLISM

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

(2018) Miguel D. Ferrer et al.   CURRENT MEDICINAL CHEMISTRY

What Is New about New Antidepressants?

(2018) Steven L. Dubovsky   PSYCHOTHERAPY AND PSYCHOSOMATICS

Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States

(2018) Deborah S. Hasin et al.   JAMA Psychiatry

Resilience and immunity

(2018) Robert Dantzer et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

(2018) Ada Ng et al.   Scientific Reports

Animal models of depression: pros and cons

(2018) Jaanus Harro   CELL AND TISSUE RESEARCH

Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

(2018) Qiqi Song et al.   Journal of Neuroinflammation

Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies

(2018) Dmitrii Pavlov et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice

(2017) Naoki Ito et al.   Journal of Neuroinflammation

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy

(2017) Paula Kopschina Feltes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels

(2017) Julie Vignisse et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action

(2017) Tatyana Strekalova et al.   MOLECULAR NEUROBIOLOGY

Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice

(2017) Nataliia Markova et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice

(2017) Ekaterina Veniaminova et al.   NEURAL PLASTICITY

Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype

(2017) Xu Kang et al.   Scientific Reports

Antidépresseurs et tolérance : déterminants et prise en charge des principaux effets indésirables

(2016) D.J. David et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice

(2016) Yvonne Couch et al.   Journal of Neuroinflammation

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia

(2015) Brandon H. Cline et al.   BEHAVIOURAL BRAIN RESEARCH

CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice

(2015) Yusuke Onaka et al.   BEHAVIOURAL BRAIN RESEARCH

Deuterium content of water increases depression susceptibility: The potential role of a serotonin-related mechanism

(2015) Tatyana Strekalova et al.   BEHAVIOURAL BRAIN RESEARCH

Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs

(2015) Elena Dale et al.   BIOCHEMICAL PHARMACOLOGY

Serotonin reuptake inhibitors and breastfeeding: a systematic review

(2015) Laura Orsolini et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

A critical review of the efficacy of non-steroidal anti-inflammatory drugs in depression

(2015) Harris A. Eyre et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Treatment-resistant depression: are animal models of depression fit for purpose?

(2015) Paul Willner et al.   PSYCHOPHARMACOLOGY

Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

(2015) Brandon H. Cline et al.   Frontiers in Behavioral Neuroscience

Animal Models of Depression and Drug Delivery with Food as an Effective Dosing Method: Evidences from Studies with Celecoxib and Dicholine Succinate

(2015) João P. Costa-Nunes et al.   Biomed Research International

FDA Approves First Celecoxib Generics

(2014) Bridget M. Kuehn   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

(2013) Michael Berk et al.   BMC Medicine

Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia

(2013) Yvonne Couch et al.   BRAIN BEHAVIOR AND IMMUNITY

Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice

(2013) Julie Vignisse et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis

(2013) Kyoung-Sae Na et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

COX-2 gene expression is correlated with cognitive function in recurrent depressive disorder

(2013) Piotr Gałecki et al.   PSYCHIATRY RESEARCH

Altered emotionality, hippocampus-dependent performance and expression of NMDA receptor subunit mRNAs in chronically stressed mice

(2013) João Costa-Nunes et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2

(2012) Brandon H Cline et al.   BMC NEUROSCIENCE

Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities

(2012) Jonathan Savitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

(2012) Ewa Malatynska et al.   EXPERIMENTAL GERONTOLOGY

Prostaglandin E2-Mediated Attenuation of Mesocortical Dopaminergic Pathway Is Critical for Susceptibility to Repeated Social Defeat Stress in Mice

(2012) K. Tanaka et al.   JOURNAL OF NEUROSCIENCE

Monoamine Theories of Depression: Historical Impact on Biomedical Research

(2012) Shai Mulinari   Journal of the History of the Neurosciences

Neurobiology of resilience

(2012) Scott J Russo et al.   NATURE NEUROSCIENCE

Non-steroidal anti-inflammatory drugs and efficacy of antidepressants in major depressive disorder

(2012) R. Uher et al.   PSYCHOLOGICAL MEDICINE

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

Celecoxib or Naproxen Treatment Does Not Benefit Depressive Symptoms in Persons Age 70 and Older: Findings From a Randomized Controlled Trial

(2011) Cynthia Fields et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Update in the methodology of the chronic stress paradigm: internal control matters

(2011) Tatyana Strekalova et al.   Behavioral and Brain Functions

Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications

(2010) Saba Aïd et al.   BIOCHIMIE

Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in Aβ-Induced Neuroinflammation

(2010) Leila Dargahi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress

(2010) Anil Kumar et al.   Neuroscience Bulletin

Cyclooxygenase-1 and -2 in spinally projecting neurons are involved in CRF-induced sympathetic activation

(2009) Naoko Yamaguchi et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain

(2009) Jian-You Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytokine, Sickness Behavior, and Depression

(2009) Robert Dantzer   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Increased Phospholipase A2 Activity and Inflammatory Response But Decreased Nerve Growth Factor Expression in the Olfactory Bulbectomized Rat Model of Depression: Effects of Chronic Ethyl-Eicosapentaenoate Treatment

(2009) C. Song et al.   JOURNAL OF NEUROSCIENCE

Measuring behavior in mice with chronic stress depression paradigm

(2009) Tatyana Strekalova et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cyclooxygenase-2 in cervical neoplasia: A review

(2008) Jennifer L. Young et al.   GYNECOLOGIC ONCOLOGY

Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study

(2008) Fabiano G. Nery et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2

(2008) Saba Aid et al.   Journal of Neuroinflammation

Neuropsychiatric disorders related to interferon and interleukins treatment

(2008) Aye Mu Myint et al.   METABOLIC BRAIN DISEASE