The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD

Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD?

(2021) Felipe Borges Almeida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm

(2020) Kyle J. Brymer et al.   NEUROPSYCHOPHARMACOLOGY

Insights on GABAergic Mechanism of PPD from Pivotal Studies of Brexanolone Injection and SAGE-217 [18E]

(2020) Samantha Meltzer-Brody et al.   OBSTETRICS AND GYNECOLOGY

Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?

(2020) Graziano Pinna   Frontiers in Endocrinology

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective

(2020) Steven M Paul et al.   Neurobiology of Stress

The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins

(2020) Felipe Borges Almeida et al.   Neurobiology of Stress

Activation of PPAR-α by N-palmitoylethanolamine engages allopregnanolone biosynthesis to modulate emotional behavior

(2019) Andrea Locci et al.   BIOLOGICAL PSYCHIATRY

Animal models of post-traumatic stress disorder and novel treatment targets

(2019) Dario Aspesi et al.   BEHAVIOURAL PHARMACOLOGY

Brexanolone: First Global Approval

(2019) Lesley J. Scott   DRUGS

Prospective biomarkers of major depressive disorder: a systematic review and meta-analysis

(2019) Mitzy Kennis et al.   MOLECULAR PSYCHIATRY

The effect of intracerebroventricular allopregnanolone on depressive-like behaviors of rats selectively bred for high and low immobility in the forced swim test

(2018) Felipe Borges Almeida et al.   PHYSIOLOGY & BEHAVIOR

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma

(2018) S.L. Pineles et al.   PSYCHONEUROENDOCRINOLOGY

Gene-environment interaction and psychiatric disorders: Review and future directions

(2018) Elham Assary et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

(2018) Julia K Gjerstad et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials

(2018) Samantha Meltzer-Brody et al.   LANCET

Salivary cortisol in post-traumatic stress disorder: a systematic review and meta-analysis

(2018) Xiongfeng Pan et al.   BMC Psychiatry

Could a blood test for PTSD and depression be on the horizon?

(2018) Dario Aspesi et al.   Expert Review of Proteomics

Animal models of PTSD: a challenge to be met

(2018) Gal Richter-Levin et al.   MOLECULAR PSYCHIATRY

Cortisol levels and cognitive profile in major depression: A comparison of currently and previously depressed patients

(2018) Ragnhild Sørensen Høifødt et al.   PSYCHONEUROENDOCRINOLOGY

A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression

(2018) Laverne Melón et al.   Frontiers in Endocrinology

Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD

(2018) Ann M. Rasmusson et al.   PSYCHONEUROENDOCRINOLOGY

Cortisol stress response in post-traumatic stress disorder, panic disorder, and major depressive disorder patients

(2017) Susann Wichmann et al.   PSYCHONEUROENDOCRINOLOGY

Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment

(2017) Andrea Locci et al.   Frontiers in Cellular Neuroscience

Sex differences in the outcome of juvenile social isolation on HPA axis function in rats

(2016) M.G. Pisu et al.   NEUROSCIENCE

The Effects of Psychological Stress on Depression

(2015) Longfei Yang et al.   Current Neuropharmacology

Post-traumatic stress disorder

(2015) Rachel Yehuda et al.   Nature Reviews Disease Primers

Post-Traumatic Stress Disorder: Theory and Treatment Update

(2014) Heather A. Kirkpatrick et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

(2014) George M. Slavich et al.   PSYCHOLOGICAL BULLETIN

Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

(2014) Graziano Pinna et al.   Frontiers in Cellular Neuroscience

Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

(2013) Nikolaos P. Daskalakis et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

New insights into the role of perinatal HPA-axis dysregulation in postpartum depression

(2013) Laura M. Glynn et al.   NEUROPEPTIDES

Multifunctional aspects of allopregnanolone in stress and related disorders

(2013) Anjana Bali et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

(2012) Stephen G. Brickley et al.   NEURON

Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress

(2012) Jane Evans et al.   NEUROPHARMACOLOGY

Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABAA Receptors

(2011) J. Sarkar et al.   JOURNAL OF NEUROSCIENCE

Depression and Hypothalamic-Pituitary-Adrenal Activation: A Quantitative Summary of Four Decades of Research

(2011) Cinnamon Stetler et al.   PSYCHOSOMATIC MEDICINE

γ-Aminobutyric Acid-Type A Receptor Deficits Cause Hypothalamic-Pituitary-Adrenal Axis Hyperactivity and Antidepressant Drug Sensitivity Reminiscent of Melancholic Forms of Depression

(2010) Qiuying Shen et al.   BIOLOGICAL PSYCHIATRY

Tolerance to allopregnanolone with focus on the GABA-A receptor

(2010) Sahruh Turkmen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats

(2010) Yukihiko Shirayama et al.   HIPPOCAMPUS

S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice

(2010) Marianela Nelson et al.   NEUROPHARMACOLOGY

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

(2010) A. Guidotti et al.   NEUROPHARMACOLOGY

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake

(2009) Graziano Pinna et al.   CURRENT OPINION IN PHARMACOLOGY

Chronic and acute stress and the prediction of major depression in women

(2009) Constance Hammen et al.   DEPRESSION AND ANXIETY

Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder

(2009) Nicolas Rohleder et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Functional role of local GABAergic influences on the HPA axis

(2008) William E. Cullinan et al.   Brain Structure & Function