Treatment-resistant depression: are animal models of depression fit for purpose?
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Title
Treatment-resistant depression: are animal models of depression fit for purpose?
Authors
Keywords
Depression, Animal models, Antidepressant, Treatment resistance, Diathesis-stress model, Validation criteria
Journal
PSYCHOPHARMACOLOGY
Volume 232, Issue 19, Pages 3473-3495
Publisher
Springer Nature
Online
2015-08-20
DOI
10.1007/s00213-015-4034-7
References
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Note: Only part of the references are listed.- The Anterior Cingulate Cortex Is a Critical Hub for Pain-Induced Depression
- (2015) Florent Barthas et al. BIOLOGICAL PSYCHIATRY
- Depression: from psychopathology to pathophysiology
- (2015) Catherine Belzung et al. CURRENT OPINION IN NEUROBIOLOGY
- ∆FosB: A transcriptional regulator of stress and antidepressant responses
- (2015) Eric J. Nestler EUROPEAN JOURNAL OF PHARMACOLOGY
- Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice
- (2015) Gloria Laryea et al. FRONTIERS IN NEUROENDOCRINOLOGY
- A meta-analysis of perceptions of defeat and entrapment in depression, anxiety problems, posttraumatic stress disorder, and suicidality
- (2015) Andy P. Siddaway et al. JOURNAL OF AFFECTIVE DISORDERS
- Increased antidepressant sensitivity after prefrontal cortex glucocorticoid receptor gene deletion in mice
- (2015) Rifat J. Hussain et al. PHYSIOLOGY & BEHAVIOR
- Mice Genetically Depleted of Brain Serotonin Do Not Display a Depression-like Behavioral Phenotype
- (2014) Mariana Angoa-Pérez et al. ACS Chemical Neuroscience
- Restoring Mood Balance in Depression: Ketamine Reverses Deficit in Dopamine-Dependent Synaptic Plasticity
- (2014) Pauline Belujon et al. BIOLOGICAL PSYCHIATRY
- Enduring Deficits in Brain Reward Function after Chronic Social Defeat in Rats: Susceptibility, Resilience, and Antidepressant Response
- (2014) Andre Der-Avakian et al. BIOLOGICAL PSYCHIATRY
- Antidepressant-like Effects of Cortical Deep Brain Stimulation Coincide With Pro-neuroplastic Adaptations of Serotonin Systems
- (2014) Avin Veerakumar et al. BIOLOGICAL PSYCHIATRY
- Repetitive transcranial magnetic stimulation as an augmentative strategy for treatment-resistant depression, a meta-analysis of randomized, double-blind and sham-controlled study
- (2014) Bangshan Liu et al. BMC Psychiatry
- EFFICACY AND ACCEPTABILITY OF ACUTE TREATMENTS FOR PERSISTENT DEPRESSIVE DISORDER: A NETWORK META-ANALYSIS
- (2014) Levente Kriston et al. DEPRESSION AND ANXIETY
- A Polymorphism in theCrhr1Gene Determines Stress Vulnerability in Male Mice
- (2014) Christiana Labermaier et al. ENDOCRINOLOGY
- Glucocorticoid receptor deletion from the dorsal raphé nucleus of mice reduces dysphoria-like behavior and impairs hypothalamic-pituitary-adrenocortical axis feedback inhibition
- (2014) Melanie Y. Vincent et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Negative learning bias is associated with risk aversion in a genetic animal model of depression
- (2014) Steven J. Shabel et al. Frontiers in Human Neuroscience
- Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: The role of the endocannabinoid system
- (2014) Hua-ning Wang et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Chronic repetitive transcranial magnetic stimulation enhances GABAergic and cholinergic metabolism in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7T
- (2014) Sang-Young Kim et al. NEUROSCIENCE LETTERS
- The BDNF Val66Met polymorphism is associated with escitalopram response in depressed patients
- (2014) Wissam El-Hage et al. PSYCHOPHARMACOLOGY
- Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience
- (2014) A. K. Friedman et al. SCIENCE
- Dysregulation of the hypothalamus-pituitary-adrenal axis predicts some aspects of the behavioral response to chronic fluoxetine: association with hippocampal cell proliferation
- (2014) Wahid Khemissi et al. Frontiers in Behavioral Neuroscience
- Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat
- (2014) Collin Challis et al. Frontiers in Behavioral Neuroscience
- Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans
- (2014) Nils C. Gassen et al. PLOS MEDICINE
- Pretreatment Brain States Identify Likely Nonresponse to Standard Treatments for Depression
- (2013) Callie L. McGrath et al. BIOLOGICAL PSYCHIATRY
- Sensitivity of depression-like behavior to glucocorticoids and antidepressants is independent of forebrain glucocorticoid receptors
- (2013) Melanie Y. Vincent et al. BRAIN RESEARCH
- Improvement in Quality of Life With Left Prefrontal Transcranial Magnetic Stimulation in Patients With Pharmacoresistant Major Depression: Acute and Six Month Outcomes
- (2013) H.B. Solvason et al. Brain Stimulation
- SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action
- (2013) Yong-Seok Oh et al. CELL
- Social stress models in depression research: what do they tell us?
- (2013) Francis Chaouloff CELL AND TISSUE RESEARCH
- Functionally altered neurocircuits in a rat model of treatment-resistant depression show prominent role of the habenula
- (2013) Natalia Gass et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Corticosteroid-binding globulin contributes to the neuroendocrine phenotype of mice selected for extremes in stress reactivity
- (2013) Gabriele E Mattos et al. JOURNAL OF ENDOCRINOLOGY
- Innovative Drugs to Treat Depression: Did Animal Models Fail to Be Predictive or Did Clinical Trials Fail to Detect Effects?
- (2013) Catherine Belzung NEUROPSYCHOPHARMACOLOGY
- Behavioral and Neurobiological Effects of Deep Brain Stimulation in a Mouse Model of High Anxiety- and Depression-Like Behavior
- (2013) Claudia Schmuckermair et al. NEUROPSYCHOPHARMACOLOGY
- Animal models of extinction-induced depression: Loss of reward and its consequences
- (2013) Joseph P. Huston et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Personality Traits as Risk Factors for Treatment-Resistant Depression
- (2013) Michio Takahashi et al. PLoS One
- Effects of chronic antidepressant treatments in a putative genetic model of vulnerability (Roman low-avoidance rats) and resistance (Roman high-avoidance rats) to stress-induced depression
- (2013) Giovanna Piras et al. PSYCHOPHARMACOLOGY
- Chronic Stress Triggers Social Aversion via Glucocorticoid Receptor in Dopaminoceptive Neurons
- (2013) J. Barik et al. SCIENCE
- Mechanisms of antidepressant resistance
- (2013) Wissam El-Hage et al. Frontiers in Pharmacology
- Long-lasting effects of chronic rTMS to treat chronic rodent model of depression
- (2012) Shu-fang Feng et al. BEHAVIOURAL BRAIN RESEARCH
- Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression
- (2012) Kim Henningsen et al. BEHAVIOURAL PHARMACOLOGY
- Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure
- (2012) M N Hill et al. MOLECULAR PSYCHIATRY
- Post-Weaning to Pre-Pubertal (‘Juvenile’) Stress: A Model of Induced Predisposition to Stress-Related Disorders
- (2012) O. Horovitz et al. NEUROENDOCRINOLOGY
- Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar–Kyoto rats
- (2012) Y. Tizabi et al. NEUROSCIENCE
- Neurobiology of chronic mild stress: Parallels to major depression
- (2012) Matthew N. Hill et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- The neurobiology of depression and antidepressant action
- (2012) Paul Willner et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
- (2012) Taka-aki Koshimizu et al. PHYSIOLOGICAL REVIEWS
- Stress-Induced Susceptibility to Sudden Cardiac Death in Mice with Altered Serotonin Homeostasis
- (2012) Luca Carnevali et al. PLoS One
- Deep brain stimulation in treatment-resistant depression in mice: Comparison with the CRF1 antagonist, SSR125543
- (2012) Carine Dournes et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors
- (2012) E. Venzala et al. PSYCHOPHARMACOLOGY
- Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior
- (2012) A Sah et al. Translational Psychiatry
- A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women
- (2011) Henry R. Kranzler et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression: A Meta-Analysis
- (2011) Valentina Nanni et al. AMERICAN JOURNAL OF PSYCHIATRY
- The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited
- (2011) Katja Karg et al. ARCHIVES OF GENERAL PSYCHIATRY
- Acute inescapable stress exposure induces long-term sleep disturbances and avoidance behavior: A mouse model of post-traumatic stress disorder (PTSD)
- (2011) J. Philbert et al. BEHAVIOURAL BRAIN RESEARCH
- Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
- (2011) Nanxin Li et al. BIOLOGICAL PSYCHIATRY
- Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Role of Serotonin and Brain Derived Neurotrophic Factor
- (2011) Clement Hamani et al. BIOLOGICAL PSYCHIATRY
- Assessing Behavioural Effects of Chronic HPA Axis Activation Using Conditional CRH-Overexpressing Mice
- (2011) Nina Dedic et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- 5-HT1A receptor sensitivity in 5-HT1B receptor KO mice is unaffected by chronic fluvoxamine treatment
- (2011) Christiaan H. Vinkers et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram.
- (2011) Vasiliki Michopoulos et al. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
- Early parental loss and depression history: Associations with recent life stress in major depressive disorder
- (2011) George M. Slavich et al. JOURNAL OF PSYCHIATRIC RESEARCH
- 5-HT2B receptors are required for serotonin-selective antidepressant actions
- (2011) S L Diaz et al. MOLECULAR PSYCHIATRY
- Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response
- (2011) A Bacq et al. MOLECULAR PSYCHIATRY
- Antidepressants recruit new neurons to improve stress response regulation
- (2011) A Surget et al. MOLECULAR PSYCHIATRY
- Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
- (2011) Bo Li et al. NATURE
- Characterization of 5-HT1A/1B−/− mice: An animal model sensitive to anxiolytic treatments
- (2011) Jean-Philippe Guilloux et al. NEUROPHARMACOLOGY
- Signaling pathways underlying the rapid antidepressant actions of ketamine
- (2011) Ronald S. Duman et al. NEUROPHARMACOLOGY
- CB1 receptor-deficient mice as a model for depression
- (2011) O. Valverde et al. NEUROSCIENCE
- A longitudinal etiologic model for symptoms of anxiety and depression in women
- (2011) K. S. Kendler et al. PSYCHOLOGICAL MEDICINE
- Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population
- (2010) Hans Jörgen Grabe et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits
- (2010) Avshalom Caspi et al. AMERICAN JOURNAL OF PSYCHIATRY
- A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
- (2010) Nancy Diazgranados et al. ARCHIVES OF GENERAL PSYCHIATRY
- Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression
- (2010) C. Winter et al. BEHAVIOURAL BRAIN RESEARCH
- The design of new antidepressants
- (2010) Catherine Belzung et al. BEHAVIOURAL PHARMACOLOGY
- The Subcallosal Cingulate Gyrus in the Context of Major Depression
- (2010) Clement Hamani et al. BIOLOGICAL PSYCHIATRY
- Role of the medial prefrontal cortex in coping and resilience
- (2010) Steven F. Maier et al. BRAIN RESEARCH
- Pharmacogenetics of antidepressive treatment
- (2010) Astrid Zobel et al. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
- Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder
- (2010) Yan-Feng Zou et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks
- (2010) J. M. Muller et al. GENES BRAIN AND BEHAVIOR
- Early Life Stress Enhances Behavioral Vulnerability to Stress through the Activation of REST4-Mediated Gene Transcription in the Medial Prefrontal Cortex of Rodents
- (2010) S. Uchida et al. JOURNAL OF NEUROSCIENCE
- Transient Early-Life Forebrain Corticotropin-Releasing Hormone Elevation Causes Long-Lasting Anxiogenic and Despair-Like Changes in Mice
- (2010) B. J. Kolber et al. JOURNAL OF NEUROSCIENCE
- Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex
- (2010) H. E. Covington et al. JOURNAL OF NEUROSCIENCE
- Mesolimbic Dopamine Neurons in the Brain Reward Circuit Mediate Susceptibility to Social Defeat and Antidepressant Action
- (2010) J.-L. Cao et al. JOURNAL OF NEUROSCIENCE
- Long-Term Duloxetine Treatment Normalizes Altered Brain-Derived Neurotrophic Factor Expression in Serotonin Transporter Knockout Rats through the Modulation of Specific Neurotrophin Isoforms
- (2010) F. Calabrese et al. MOLECULAR PHARMACOLOGY
- Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression and memory-related behaviors
- (2010) L Conboy et al. MOLECULAR PSYCHIATRY
- Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
- (2010) Diego A Pizzagalli NEUROPSYCHOPHARMACOLOGY
- Forebrain glucocorticoid receptor overexpression increases environmental reactivity and produces a stress-induced spatial discrimination deficit
- (2010) E.K. Hebda-Bauer et al. NEUROSCIENCE
- Association between Repeated Unpredictable Chronic Mild Stress (UCMS) Procedures with a High Fat Diet: A Model of Fluoxetine Resistance in Mice
- (2010) Elsa Isingrini et al. PLoS One
- The Influence of Comorbid Personality Disorder and Neuroticism on Treatment Outcome in First Episode Depression
- (2010) Camilla Bock et al. PSYCHOPATHOLOGY
- Early life stress paradigms in rodents: potential animal models of depression?
- (2010) Mathias V. Schmidt et al. PSYCHOPHARMACOLOGY
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- Cognitive theory and therapy of anxiety and depression: Convergence with neurobiological findings
- (2010) David A. Clark et al. TRENDS IN COGNITIVE SCIENCES
- Regulation of Gene Expression of Catecholamine Biosynthetic Enzymes in Dopamine-��-Hydroxylase- and CRH-Knockout Mice Exposed to Stress
- (2009) Richard Kvet��ansk�� et al. Annals of the New York Academy of Sciences
- Protective Effect of CRHR1 Gene Variants on the Development of Adult Depression Following Childhood Maltreatment
- (2009) Guilherme Polanczyk et al. ARCHIVES OF GENERAL PSYCHIATRY
- Sex Differences in Animal Models of Depression and Antidepressant Response
- (2009) Christina Dalla et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress
- (2009) Yadira Ibarguen-Vargas et al. BEHAVIOURAL BRAIN RESEARCH
- Increased Vulnerability to Depressive-Like Behavior of Mice with Decreased Expression of VGLUT1
- (2009) Alvaro L. Garcia-Garcia et al. BIOLOGICAL PSYCHIATRY
- Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient
- (2009) Alexander Sartorius et al. BIOLOGICAL PSYCHIATRY
- Targeted electrode-based modulation of neural circuits for depression
- (2009) Helen S. Mayberg JOURNAL OF CLINICAL INVESTIGATION
- Evidence That Patients With Single Versus Recurrent Depressive Episodes Are Differentially Sensitive to Treatment Discontinuation
- (2009) Nil Kaymaz et al. JOURNAL OF CLINICAL PSYCHIATRY
- Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders
- (2009) A. Knapman et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl
- (2009) Daniela Schulz et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- CNR1 Gene is Associated with High Neuroticism and Low Agreeableness and Interacts with Recent Negative Life Events to Predict Current Depressive Symptoms
- (2009) Gabriella Juhasz et al. NEUROPSYCHOPHARMACOLOGY
- Rhythmicity in Mice Selected for Extremes in Stress Reactivity: Behavioural, Endocrine and Sleep Changes Resembling Endophenotypes of Major Depression
- (2009) Chadi Touma et al. PLoS One
- The genetic and environmental relationship between major depression and the five-factor model of personality
- (2009) K. S. Kendler et al. PSYCHOLOGICAL MEDICINE
- Influence of Child Abuse on Adult Depression
- (2008) Rebekah G. Bradley et al. ARCHIVES OF GENERAL PSYCHIATRY
- Increased Anterior Cingulate Cortical Activity in Response to Fearful Faces: A Neurophysiological Biomarker that Predicts Rapid Antidepressant Response to Ketamine
- (2008) Giacomo Salvadore et al. BIOLOGICAL PSYCHIATRY
- Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression
- (2008) Katharina Domschke et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder
- (2008) M Kato et al. MOLECULAR PSYCHIATRY
- Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression
- (2008) Manfred Uhr et al. NEURON
- Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal
- (2008) Alexandre Surget et al. NEUROPSYCHOPHARMACOLOGY
- Requirement of AQP4 for Antidepressive Efficiency of Fluoxetine: Implication in Adult Hippocampal Neurogenesis
- (2008) Hui Kong et al. NEUROPSYCHOPHARMACOLOGY
- The ABCs of depression: Integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression.
- (2008) Janet Shibley Hyde et al. PSYCHOLOGICAL REVIEW
- The role of the arginine vasopressin Avp1b receptor in the acute neuroendocrine action of antidepressants
- (2008) Lesley Q. Stewart et al. PSYCHONEUROENDOCRINOLOGY
- Mice selected for high versus low stress reactivity: A new animal model for affective disorders
- (2008) Chadi Touma et al. PSYCHONEUROENDOCRINOLOGY
- Selective Loss of Brain-Derived Neurotrophic Factor in the Dentate Gyrus Attenuates Antidepressant Efficacy
- (2007) Megumi Adachi et al. BIOLOGICAL PSYCHIATRY
- Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeys
- (2007) Holly Jarrell et al. PHYSIOLOGY & BEHAVIOR
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