Cellular models for beta-cell function and diabetes gene therapy

Nutrient regulation of β-cell function: what do islet cell/animal studies tell us?

(2017) R Carlessi et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

(2017) Nikhil R. Gandasi et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of an encapsulated insulin secreting human pancreatic beta cell line in a modular microfluidic device

(2017) Argia Acarregui et al.   JOURNAL OF DRUG TARGETING

Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells

(2017) Suma Elumalai et al.   Redox Biology

The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion

(2017) Shams Kursan et al.   Scientific Reports

Dopamine Receptor Signaling in MIN6 β -Cells Revealed by Fluorescence Fluctuation Spectroscopy

(2016) Brittany Caldwell et al.   BIOPHYSICAL JOURNAL

2. Classification and Diagnosis of Diabetes

(2016)   DIABETES CARE

Dogfish glucagon analogues counter hyperglycaemia and enhance both insulin secretion and action in diet-induced obese diabetic mice

(2016) F. P. M. O'Harte et al.   DIABETES OBESITY & METABOLISM

Mass production of functional human pancreatic β-cells: why and how?

(2016) R. Scharfmann et al.   DIABETES OBESITY & METABOLISM

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

(2016) Ewa Gurgul-Convey et al.   DIABETOLOGIA

Long-Term Exposure of Pancreatic β-Cells to Palmitate Results in SREBP-1C-Dependent Decreases in GLP-1 Receptor Signaling via CREB and AKT and Insulin Secretory Response

(2016) Annalisa Natalicchio et al.   ENDOCRINOLOGY

Functionality and antidiabetic utility of β- and L-cell containing pseudoislets

(2016) Alastair D. Green et al.   EXPERIMENTAL CELL RESEARCH

Low dose monoethyl phthalate (MEP) exposure triggers proliferation by activating PDX-1 at 1.1B4 human pancreatic beta cells

(2016) Celal Güven et al.   FOOD AND CHEMICAL TOXICOLOGY

Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival

(2016) Dawood Khan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

Molecular Mechanisms of Toxicity and Cell Damage by Chemicals in a Human Pancreatic Beta Cell Line, 1.1B4

(2016) Srividya Vasu et al.   PANCREAS

Generation of Functional Beta-Like Cells from Human Exocrine Pancreas

(2016) Maria J. Lima et al.   PLoS One

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

(2016) Gemma L. Pearson et al.   Molecular Metabolism

Pancreatic beta cell lines and their applications in diabetes mellitus research

(2016) Masa Skelin   ALTEX-Alternatives to Animal Experimentation

Physiological characterization of the human EndoC-βH1 β-cell line

(2015) Ewa Gurgul-Convey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Islet Transplantation for Type 1 Diabetes, 2015: What Have We Learned From Alloislet and Autoislet Successes?

(2015) R. Paul Robertson   DIABETES CARE

Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells

(2015) Alastair D. Green et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Synergistic Activations ofREG IαandREG IβPromoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human PancreaticβCells

(2015) Akiyo Yamauchi et al.   Journal of Diabetes Research

A human beta cell line with drug inducible excision of immortalizing transgenes

(2015) Marion Benazra et al.   Molecular Metabolism

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Membranes to achieve immunoprotection of transplanted islets

(2014) Julien Schweicher   Frontiers in Bioscience-Landmark

Development of a conditionally immortalized human pancreatic β cell line

(2014) Raphaël Scharfmann et al.   JOURNAL OF CLINICAL INVESTIGATION

In search of a surrogate: engineering human beta cell lines for therapy

(2014) Brittney N. Newby et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreas β cell regeneration and type 1 diabetes (Review)

(2014) JINXIAO WU et al.   Experimental and Therapeutic Medicine

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4

(2013) Srividya Vasu et al.   BIOLOGICAL CHEMISTRY

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistancein vivoand cause pancreatic β-cell dysfunction and deathin vitro

(2013) Mauricio Krause et al.   CLINICAL SCIENCE

Alternatives to islet transplantation: future cell sources of beta-like cells

(2013) Helge Bruns et al.   CLINICAL TRANSPLANTATION

Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice

(2013) S Vasu et al.   GENE THERAPY

Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene

(2013) Hiroyo Ota et al.   LIFE SCIENCES

Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia

(2013) Srividya Vasu et al.   Islets

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

(2012) Hong Guo-Parke et al.   JOURNAL OF ENDOCRINOLOGY

Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion

(2011) Jane T. McCluskey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of islet structure and cellular interactions in the control of insulin secretion

(2011) Catriona Kelly et al.   Islets

Comparison of Insulin Release From MIN6 Pseudoislets and Pancreatic Islets of Langerhans Reveals Importance of Homotypic Cell Interactions

(2010) Catriona Kelly et al.   PANCREAS

A Practical Guide to Rodent Islet Isolation and Assessment

(2009) Jeffrey D. Carter et al.   BIOLOGICAL PROCEDURES ONLINE

The CM cell line derived from liver metastasis of malignant human insulinoma is not a valid beta cell model for in vitro studies

(2008) Claudia Gragnoli   JOURNAL OF CELLULAR PHYSIOLOGY