Focused review on dual inhibition of quorum sensing and efflux pumps: A potential way to combat multi drug resistant Staphylococcus aureus infections

Potential strategies for the management of drug resistant tuberculosis

(2020) Divakar Sharma et al.   Journal of Global Antimicrobial Resistance

Effect of Vitamin K3 Inhibiting the Function of NorA Efflux Pump and Its Gene Expression on Staphylococcus aureus

(2020) Saulo R. Tintino et al.   Membranes

Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance

(2020) Nikoletta Szemerédi et al.   Antibiotics-Basel

Genetic Diversity of norA, Coding for a Main Efflux Pump of Staphylococcus aureus

(2019) Sofia Santos Costa et al.   Frontiers in Genetics

Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors

(2019) Tímea Mosolygó et al.   MOLECULES

Antibiotics versus biofilm: an emerging battleground in microbial communities

(2019) Divakar Sharma et al.   Antimicrobial Resistance and Infection Control

Baicalin Inhibits Biofilm Formation and the Quorum-Sensing System by Regulating the MsrA Drug Efflux Pump in Staphylococcus saprophyticus

(2019) Jinli Wang et al.   Frontiers in Microbiology

Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators

(2018) Fernando Andre Pereira Marques Duraes et al.   CURRENT MEDICINAL CHEMISTRY

N,N′ -disubstituted cinnamamide derivatives potentiate ciprofloxacin activity against overexpressing NorA efflux pump Staphylococcus aureus 1199B strains

(2018) Sylvie Radix et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of bacterial efflux pumps in biofilm formation

(2018) Ilyas Alav et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

(2018) Renee M. Fleeman et al.   Frontiers in Microbiology

Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System

(2018) Li Tan et al.   Frontiers in Microbiology

Ferulic acid derivative inhibits NorA efflux and in combination with ciprofloxacin curtails growth of MRSA in vitro and in vivo

(2018) Niranjana Sri Sundaramoorthy et al.   MICROBIAL PATHOGENESIS

Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus

(2018) Santosh K. Rath et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance

(2018) Varsha Shriram et al.   Frontiers in Microbiology

Investigation on the effect of known potent S. aureus NorA efflux pump inhibitors on the staphylococcal biofilm formation

(2017) Stefano Sabatini et al.   RSC Advances

Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy

(2017) Kenji Ikemura et al.   Frontiers in Pharmacology

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models

(2017) Amelia Muhs et al.   Scientific Reports

Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis

(2017) Jonathan Nzakizwanayo et al.   Scientific Reports

Pathogenesis ofStaphylococcus aureusBloodstream Infections

(2016) Lena Thomer et al.   Annual Review of Pathology-Mechanisms of Disease

Plant Natural Products Targeting Bacterial Virulence Factors

(2016) Laura Nunes Silva et al.   CHEMICAL REVIEWS

Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria

(2016) Yinhu Wang et al.   CURRENT DRUG TARGETS

 Biofilm formation by Pseudomonas aeruginosa and disinfectant susceptibility of planktonic and biofilm cells

(2016) Olszewska Magdalena A et al.   CZECH JOURNAL OF FOOD SCIENCES

Antisense locked nucleic acids targetingagrAinhibit quorum sensing and pathogenesis of community-associated methicillin-resistantStaphylococcus aureus

(2016) F. Da et al.   JOURNAL OF APPLIED MICROBIOLOGY

Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-ResistantStaphylococcus aureusInfections

(2016) Elaine M. Waters et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound

(2016) Oriana Simonetti et al.   PLoS One

ω-Hydroxyemodin Limits Staphylococcus aureus Quorum Sensing-Mediated Pathogenesis and Inflammation

(2015) Seth M. Daly et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Prevention and treatment ofStaphylococcus aureusbiofilms

(2015) Mohini Bhattacharya et al.   Expert Review of Anti-Infective Therapy

Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control

(2015) S. L. Percival et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Novel Quorum-Quenching Agents Promote Methicillin-Resistant Staphylococcus aureus (MRSA) Wound Healing and Sensitize MRSA to β-Lactam Antibiotics

(2014) David Kuo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

(2014) Jingjing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Active Efflux Influences the Potency of Quorum Sensing Inhibitors inPseudomonas aeruginosa

(2014) Joseph D. Moore et al.   CHEMBIOCHEM

Investigation of the antibacterial activity and efflux pump inhibitory effect of co-loaded piperine and gentamicin nanoliposomes in methicillin-resistantStaphylococcus aureus

(2014) Bahman Khameneh et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Protective efficacy of piperine against Mycobacterium tuberculosis

(2014) Sandeep Sharma et al.   TUBERCULOSIS

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

(2014) Erin K. Sully et al.   PLoS Pathogens

Discovery of Antivirulence Agents against Methicillin-Resistant Staphylococcus aureus

(2013) Varandt Khodaverdian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of drug efflux pumps inStaphylococcus aureus: current status of potentiating existing antibiotics

(2013) Bryan D Schindler et al.   Future Microbiology

Cooperation, Quorum Sensing, and Evolution of Virulence in Staphylococcus aureus

(2013) Eric J. G. Pollitt et al.   INFECTION AND IMMUNITY

Inhibition of multidrug efflux as a strategy to prevent biofilm formation

(2013) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bioactive metabolites from an endophytic Cryptosporiopsis sp. inhabiting Clidemia hirta

(2013) Mahesh K. Zilla et al.   PHYTOCHEMISTRY

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoroquinolone resistant mechanisms in methicillin-resistant Staphylococcus aureus clinical isolates in Cairo, Egypt

(2013) Rasha A Hashem et al.   Journal of Infection in Developing Countries

Virulence factors of theMycobacterium tuberculosiscomplex

(2013) Marina A. Forrellad et al.   Virulence

Staphylococcus aureus autoinducer-2 quorum sensing decreases biofilm formation in an icaR-dependent manner

(2012) Dan Yu et al.   BMC MICROBIOLOGY

Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees

(2012) J. G. Holler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus

(2012) N. P. Kalia et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus

(2011) Z. M. Mirza et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of theS. aureusNorA Efflux Pump

(2011) Stefano Sabatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quorum Sensing Inhibition by Phenothiazines and Related Compounds

(2011) Zoltan Gabor Varga et al.   Letters in Drug Design & Discovery

Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria

(2011) Yiannis C. Fiamegos et al.   PLoS One

The Staphylococcus aureus RNome and Its Commitment to Virulence

(2011) Brice Felden et al.   PLoS Pathogens

Synergistic Activities of an Efflux Pump Inhibitor and Iron Chelators against Pseudomonas aeruginosa Growth and Biofilm Formation

(2010) Y. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluoroquinolone Efflux by the Plasmid-Mediated Multidrug Efflux Pump QacB Variant QacBIII in Staphylococcus aureus

(2010) H. Nakaminami et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Increased Mortality with Accessory Gene Regulator (agr) Dysfunction inStaphylococcus aureusamong Bacteremic Patients

(2010) Marin L. Schweizer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

(2010) B. P. Howden et al.   CLINICAL MICROBIOLOGY REVIEWS

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus: Recognition and prevention in intensive care units

(2010) Michael Y. Lin et al.   CRITICAL CARE MEDICINE

Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses

(2010) J.B. Kaplan   JOURNAL OF DENTAL RESEARCH

Quorum sensing in bacterial virulence

(2010) L. C. M. Antunes et al.   MICROBIOLOGY-SGM

Quorum Sensing Inhibitors ofStaphylococcus aureusfrom Italian Medicinal Plants

(2010) Cassandra Quave et al.   PLANTA MEDICA

Inhibition of quorum-sensing signals by essential oils

(2009) Mira Ágnes Szabó et al.   PHYTOTHERAPY RESEARCH

Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation

(2008) M. Kvist et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Citral derived amides as potent bacterial NorA efflux pump inhibitors

(2008) Niranjan Thota et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus

(2008) Joseph I. Ambrus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of PSSRI-based inhibitors of Staphylococcus aureus multidrug efflux pumps

(2008) Nadezhda German et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus

(2008) Shu Y. Queck et al.   MOLECULAR CELL

Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA