Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

(2017) Diana Machado et al.   PeerJ

Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents

(2016) Shayna Sandhaus et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa

(2016) Jacqueline L. von Salm et al.   ORGANIC LETTERS

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

(2016) Hanno Sjuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis

(2016) Diana Machado et al.   PLoS One

Pyridodiazepine Amines Are Selective Therapeutic Agents for Helicobacter pylori by Suppressing Growth through Inhibition of Glutamate Racemase but Are Predicted To Require Continuous Elevated Levels in Plasma To Achieve Clinical Efficacy

(2015) Boudewijn L. M. de Jonge et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens

(2015) Renee Fleeman et al.   JOURNAL OF MEDICINAL CHEMISTRY

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity

(2015) Jian-Long Li et al.   Scientific Reports

RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

(2015) Henrietta Venter et al.   Frontiers in Microbiology

Recent advances toward a molecular mechanism of efflux pump inhibition

(2015) Timothy J. Opperman et al.   Frontiers in Microbiology

Identification of Acinetobacter baumannii Serum-Associated Antibiotic Efflux Pump Inhibitors

(2014) Catlyn Blanchard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

(2014) Jingjing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Update on the antibiotic resistance crisis

(2014) Gian Maria Rossolini et al.   CURRENT OPINION IN PHARMACOLOGY

Antibacterial Activity of a Series of N2,N4-Disubstituted Quinazoline-2,4-diamines

(2014) Kurt S. Van Horn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor

(2013) Shashank Gupta et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

(2013) Timothy J. Opperman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toxicity of Polyamines and Their Metabolic Products

(2013) Anthony E. Pegg   CHEMICAL RESEARCH IN TOXICOLOGY

Aminoglycoside therapy in infectious diseases

(2013) Panagiotis Poulikakos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Native Efflux Pumps Contribute Resistance to Antimicrobials of Skin and the Ability of Staphylococcus aureus to Colonize Skin

(2013) Q. C. Truong-Bolduc et al.   JOURNAL OF INFECTIOUS DISEASES

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

(2013) Jinhua Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors

(2013) Radleigh Santos et al.   MOLECULES

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Polyamines Inhibit Porin-Mediated Fluoroquinolone Uptake in Mycobacteria

(2013) Jansy Passiflora Sarathy et al.   PLoS One

Combination approaches to combat multidrug-resistant bacteria

(2013) Roberta J. Worthington et al.   TRENDS IN BIOTECHNOLOGY

Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm

(2013) Sara M. Soto   Virulence

Biochemistry of Bacterial Multidrug Efflux Pumps

(2012) Sanath Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa

(2011) Momen Askoura et al.   Libyan Journal of Medicine

Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library

(2010) Kate J. Reilley et al.   AAPS Journal

The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

(2010) T. Auerbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly and transport mechanism of tripartite drug efflux systems

(2009) Rajeev Misra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms

(2009) P. D. Lister et al.   CLINICAL MICROBIOLOGY REVIEWS

Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli

(2009) Laura Paixão et al.   Journal of Biological Engineering

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

(2007) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES