A comprehensive insight into autophagy and its potential signaling pathways as a therapeutic target in podocyte injury

Sirtuins play critical and diverse roles in acute kidney injury

(2021) Kevin Peasley et al.   PEDIATRIC NEPHROLOGY

CD80 Insights as Therapeutic Target in the Current and Future Treatment Options of Frequent-Relapse Minimal Change Disease

(2021) Yoong Mond Teh et al.   Biomed Research International

Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway

(2021) Hong Liu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Podocyte Aging: Why and How Getting Old Matters

(2021) Stuart J. Shankland et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes

(2020) Mamoru Yoshibayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR/P70S6K/4EBP1 pathway

(2020) Chao Li et al.   LIFE SCIENCES

Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome

(2020) Ayu Ogawa-Akiyama et al.   PLoS One

Liver X receptor activation induces podocyte injury via inhibiting autophagic activity

(2020) Ziyi Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Intermittent Fasting: Physiological Implications on Outcomes in Mice and Men

(2020) Ju Hee Lee et al.   PHYSIOLOGY

Regulation of podocytes function by AMP-activated protein kinase

(2020) Dorota Rogacka et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors

(2020) Tian Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Autophagy in kidney homeostasis and disease

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Resveratrol: Evidence for Its Nephroprotective Effect in Diabetic Nephropathy

(2020) Vemana Gowd et al.   Advances in Nutrition

Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice

(2020) Fang Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting Energy Pathways in Kidney Disease: The Roles of Sirtuins, AMPK, and PGC1α

(2020) Amanda J. Clark et al.   KIDNEY INTERNATIONAL

Role of IRE1α in podocyte proteostasis and mitochondrial health

(2020) José R. Navarro-Betancourt et al.   Cell Death Discovery

Role of sirtuin-1 in diabetic nephropathy

(2019) Wanning Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cyclocarya paliurus triterpenic acids fraction attenuates kidney injury via AMPK-mTOR-regulated autophagy pathway in diabetic rats

(2019) Xuan-Xuan Zhang et al.   PHYTOMEDICINE

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

(2019) Dan Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions

(2019) Di Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

NLRP3 inflammasome negatively regulates podocyte autophagy in diabetic nephropathy

(2019) Yun Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice

(2019) Jung-Yeon Kim et al.   Antioxidants

Podocytes maintain high basal levels of autophagy independent of mtor signaling

(2019) Tillmann Bork et al.   Autophagy

Chronic kidney disease: Biomarker diagnosis to therapeutic targets

(2019) Yan-Ni Wang et al.   CLINICA CHIMICA ACTA

A Review of Podocyte Biology

(2018) Puneet Garg   AMERICAN JOURNAL OF NEPHROLOGY

Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy

(2018) Fengbo Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis

(2018) Ming Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli

(2018) Xiaodan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Knockdown of NUP160 inhibits cell proliferation, induces apoptosis, autophagy and cell migration, and alters the expression and localization of podocyte associated molecules in mouse podocytes

(2018) Ping Wang et al.   GENE

Sirtuins in Renal Health and Disease

(2018) Marina Morigi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

mTOR Inhibition and Kidney Diseases

(2018) Maggie K.M. Ma et al.   TRANSPLANTATION

Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway

(2018) Xiaojiang Zhan et al.   MOLECULAR IMMUNOLOGY

ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies

(2017) Claire E. Martin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deletion of inositol-requiring enzyme-1α in podocytes disrupts glomerular capillary integrity and autophagy

(2017) Daniel Robert Kaufman et al.   MOLECULAR BIOLOGY OF THE CELL

Chinese medicine for diabetic kidney disease in China

(2017) Yumin Wen et al.   NEPHROLOGY

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

Podocyte injury and its consequences

(2016) Michio Nagata   KIDNEY INTERNATIONAL

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging role of podocyte autophagy in the progression of diabetic nephropathy

(2015) Mako Yasuda-Yamahara et al.   Autophagy

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

(2015) Sabbir Khan et al.   BIOCHIMIE

SIRT1 Protects Against Oxidative Stress-Induced Endothelial Progenitor Cells Apoptosis by Inhibiting FOXO3a via FOXO3a Ubiquitination and Degradation

(2015) Yu-Qiang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirtuin and metabolic kidney disease

(2015) Shu Wakino et al.   KIDNEY INTERNATIONAL

Unknown

(2015) Lili Kong et al.   MOLECULAR MEDICINE

Podocyte directed therapy of nephrotic syndrome—can we bring the inside out?

(2015) Janina Müller-Deile et al.   PEDIATRIC NEPHROLOGY

Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy

(2014) Juan Alejandro Oliva Trejo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy modulates endoplasmic reticulum stress-induced cell death in podocytes: A protective role

(2014) Yu-Chi Cheng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress

(2014) Li Fang et al.   EXPERIMENTAL CELL RESEARCH

Podocyte autophagic activity plays a protective role in renal injury and delays the progression of podocytopathies

(2014) Caihong Zeng et al.   JOURNAL OF PATHOLOGY

Alterations in the Ubiquitin Proteasome System in Persistent but Not Reversible Proteinuric Diseases

(2014) M. Beeken et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice

(2014) Tangli Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nephroprotective action of sirtuin 1 (SIRT1)

(2013) Dorota Polak-Jonkisz et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Repeated Systemic Administration of Human Adipose-Derived Stem Cells Attenuates Overt Diabetic Nephropathy in Rats

(2013) Li Zhang et al.   STEM CELLS AND DEVELOPMENT

Emerging role of autophagy in kidney function, diseases and aging

(2012) Tobias B. Huber et al.   Autophagy

Aldosterone blockade and the mineralocorticoid receptor in the management of chronic kidney disease: current concepts and emerging treatment paradigms

(2012) Linda Shavit et al.   KIDNEY INTERNATIONAL

HMGB1 as an autophagy sensor in oxidative stress

(2011) Rui Kang et al.   Autophagy

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

Podocyte Injury Damages Other Podocytes

(2011) T. Matsusaka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY