Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway

Saxagliptin attenuates glomerular podocyte injury by increasing the expression of renal nephrin and podocin in type 2 diabetic rats

(2019) Yuanyuan Hu et al.   ACTA DIABETOLOGICA

Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions

(2019) Di Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy

(2016) Hong Liu et al.   ACTA PHARMACOLOGICA SINICA

Emodin Ameliorates High Glucose Induced-Podocyte Epithelial-Mesenchymal Transition In-Vitro and In-Vivo

(2015) Tingfang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid

(2015) Zhi-Min Mao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Functions of the podocyte proteins nephrin and Neph3 and the transcriptional regulation of their genes

(2013) Mervi Ristola et al.   CLINICAL SCIENCE

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

Emodin Regulates Glucose Utilization by Activating AMP-activated Protein Kinase

(2013) Parkyong Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats

(2012) Thing-Fong Tzeng et al.   Evidence-based Complementary and Alternative Medicine

Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy

(2012) E. Jennifer Weil et al.   KIDNEY INTERNATIONAL

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

(2011) Elaine A. Dunlop et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 CellsIn Vitroand Enhances Phagocytosis in Leukemia MiceIn Vivo

(2011) Yuan-Chang Chang et al.   Evidence-based Complementary and Alternative Medicine

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

(2011) Munehiro Kitada et al.   Experimental Diabetes Research

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The role of autophagy in unilateral ureteral obstruction rat model

(2011) WAN-YOUNG KIM et al.   NEPHROLOGY

Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1α and intracellular superoxide dismutases

(2011) Jung-Min Yon et al.   REPRODUCTIVE TOXICOLOGY

ANG II promotes autophagy in podocytes

(2010) Anju Yadav et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose

(2009) Xuejuan Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL