Shear stress–induced cellular senescence blunts liver regeneration through Notch–sirtuin 1–P21/P16 axis

Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

(2021) Huan-Tian Zhang et al.   Cell Death & Disease

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

(2020) Chi Zhang et al.   Aging-US

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice

(2020) Birgit Ritschka et al.   GENES & DEVELOPMENT

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

Metabolic regulation of immune cells in proinflammatory microenvironments and diseases during ageing

(2020) Pei-Heng Li et al.   AGEING RESEARCH REVIEWS

SIRT1 is downregulated by autophagy in senescence and ageing

(2020) Caiyue Xu et al.   NATURE CELL BIOLOGY

Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease

(2019) Elizabeth Min et al.   EXPERIMENTAL CELL RESEARCH

Notch Signaling Mediates Secondary Senescence

(2019) Yee Voan Teo et al.   Cell Reports

Cellular senescence in development, regeneration and disease

(2019) Muriel Rhinn et al.   DEVELOPMENT

Non-invasive Imaging and Modeling of Liver Regeneration After Partial Hepatectomy

(2019) Sara Zafarnia et al.   Frontiers in Physiology

Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice

(2018) Juan-Li Duan et al.   HEPATOLOGY

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis

(2018) Inken Waltl et al.   NEUROBIOLOGY OF DISEASE

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

(2018) Sofia Ferreira-Gonzalez et al.   Nature Communications

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

(2018) Thomas G. Bird et al.   Science Translational Medicine

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Epigenetic regulation in cell senescence

(2017) Li-Qin Cheng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

NOTCH and the 2 SASPs of senescence

(2016) Matthew Hoare et al.   CELL CYCLE

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation

(2016) Juan-Juan Chen et al.   Scientific Reports

Hes1: a key role in stemness, metastasis and multidrug resistance

(2015) Zi-Hao Liu et al.   CANCER BIOLOGY & THERAPY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

(2015) Junhu Wan et al.   NUCLEIC ACIDS RESEARCH

Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

(2014) Jing Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shear Stress Activates eNOS at the Endothelial Apical Surface Through β1 Containing Integrins and Caveolae

(2013) Baohua Yang et al.   Cellular and Molecular Bioengineering

Liver regeneration by stem/progenitor cells

(2013) Tohru Itoh et al.   HEPATOLOGY

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier Dysfunction

(2011) Deepak Venkatesh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

p53 and p16INK4A independent induction of senescence by chromatin-dependent alteration of S-phase progression

(2011) Alexandre Prieur et al.   Nature Communications

Evolutionary Scenarios of Notch Proteins

(2009) A. Theodosiou et al.   MOLECULAR BIOLOGY AND EVOLUTION

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL