Prevention of ferroptosis in acute scenarios: an in vitro study with classic and novel anti-ferroptotic compounds

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

(2021) Delin Chen et al.   Nature Communications

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

Ferroptosis in Liver Diseases: An Overview

(2020) Martina Maria Capelletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1

(2020) Danúbia B. Santos et al.   MOLECULAR NEUROBIOLOGY

New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells

(2020) Diones Caeran Bueno et al.   MOLECULAR NEUROBIOLOGY

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

(2020) Laura Mahoney-Sánchez et al.   PROGRESS IN NEUROBIOLOGY

Iron, ferroptosis, and new insights for prevention in acute kidney injury

(2020) Bartlomiej Borawski et al.   Advances in Medical Sciences

Emerging roles of ferroptosis in liver pathophysiology

(2020) Kyu Min Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Resolving the paradox of ferroptotic cell death: ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

(2020) Tamil S. Anthonymuthu et al.   Redox Biology

Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms

(2020) Lulu Sun et al.   DNA AND CELL BIOLOGY

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

(2020) Cadiele Oliana Reichert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy

(2019) Amanda H. Kahn-Kirby et al.   PLoS One

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

(2018) Anja Jelinek et al.   FREE RADICAL BIOLOGY AND MEDICINE

Design, Synthesis, and In Vitro Evaluation of a Novel Probucol Derivative: Protective Activity in Neuronal Cells Through GPx Upregulation

(2018) Ruth Liliám Quispe et al.   MOLECULAR NEUROBIOLOGY

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

(2018) Lars Devisscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

(2017) Nilda V. Barbosa et al.   Metallomics

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

(2016) Sam Hofmans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Succinobucol, a Non-Statin Hypocholesterolemic Drug, Prevents Premotor Symptoms and Nigrostriatal Neurodegeneration in an Experimental Model of Parkinson’s Disease

(2016) Danúbia Bonfanti Santos et al.   MOLECULAR NEUROBIOLOGY

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity

(2015) Dirleise Colle et al.   MOLECULAR NEUROBIOLOGY

Probucol mitigates streptozotocin-induced cognitive and biochemical changes in mice

(2015) D.B. Santos et al.   NEUROSCIENCE

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Succinobucol versus probucol: Higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro

(2013) Dirleise Colle et al.   MITOCHONDRION

Probucol Affords Neuroprotection in a 6-OHDA Mouse Model of Parkinson’s Disease

(2013) Renata Pietsch Ribeiro et al.   NEUROCHEMICAL RESEARCH

Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: A comparison with ebselen

(2013) Andreza Fabro de Bem et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Probucol Increases Striatal Glutathione Peroxidase Activity and Protects against 3-Nitropropionic Acid-Induced Pro-Oxidative Damage in Rats

(2013) Dirleise Colle et al.   PLoS One

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice

(2011) Danúbia B. Santos et al.   EXPERIMENTAL NEUROLOGY

Probucol Increases Glutathione Peroxidase-1 Activity and Displays Long-Lasting Protection against Methylmercury Toxicity in Cerebellar Granule Cells

(2009) Marcelo Farina et al.   TOXICOLOGICAL SCIENCES

Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial

(2008) Jean-Claude Tardif et al.   LANCET