Article
Biochemistry & Molecular Biology
Laura E. Diepeveen, Gaby Stegemann, Erwin T. Wiegerinck, Rian Roelofs, Myrthe Naber, Olivier Loreal, Bart Smeets, Frank Thevenod, Dorine W. Swinkels, Rachel P. L. van Swelm
Summary: Hemolysis can cause acute kidney injury, and the iron regulatory hormone hepcidin plays a protective role during this process. The synthesis of renal hepcidin is induced by iron and hemin through the Nrf2 pathway. Kidney-specific mechanisms of hepcidin regulation exist, highlighting the complexity of iron regulatory mechanisms during AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Yanmeng Li, Qin Ouyang, Zhibin Chen, Wei Chen, Bei Zhang, Song Zhang, Min Cong, Anjian Xu
Summary: Intracellular labile iron has a dual function in regulating iron metabolism, inducing hepcidin expression in hepatocytes and stimulating the expression of bone morphogenic protein 6 (BMP6) in liver sinusoidal endothelial cells (LSECs) through the secretion of TNF alpha by hepatocytes. TNF alpha blockade dysregulates iron metabolism during iron overload and TNF alpha administration reduces iron burden in Hfe knockout hemochromatosis mice. TNF alpha could be a potential therapeutic target for HFE-associated hemochromatosis.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Nanoscience & Nanotechnology
Penghui Li, Huan Wang, Yanjie Zhang, Zitong Zhu, Mengmeng Liu, Jinsong Ren, Xinchen Liu
Summary: Chemotherapeutic drug-induced acute kidney injury (AKI) can be attenuated using renal clearable quantum dot-drug conjugates (QDCs) composed of carbon quantum dot (CDs), deferoxamine (DFO), and poly(ethylene glycol) (PEG). The CDs component in QDCs provides high renal specificity to remove pathological labile iron species and exert antioxidative effects, effectively reducing renal oxidative damage caused by excessive reactive oxygen species (ROS) generation. QDCs effectively inhibit ferroptosis and apoptosis in cisplatin-induced AKI mice, offering a new paradigm for enhanced AKI treatment by addressing both symptoms and root causes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medical Laboratory Technology
Ze-Liang Qiu, Bi-Qing Yan, Rui Zhao, Dong-Wei Xu, Kan Shen, Xing-Qi Deng, Shi-Qi Lu
Summary: This study aimed to assess the early predictive values of hepcidin, NGAL, and their combination for secondary AKI in patients with sepsis. Results indicated that higher serum hepcidin and urine NGAL levels at admission were independent predictors of AKI development in critically septic patients. Serum hepcidin and urine NGAL were comparable predictive indicators of AKI occurrence, with their combination showing improved accuracy in prediction.
CLINICA CHIMICA ACTA
(2021)
Review
Oncology
Artur Slomka, Monika Lecka, Jan Styczynski
Summary: This systematic review provides an overview of observational studies on the association between hepcidin and acute leukemia (AL) or hematopoietic cell transplantation (HCT). The review highlights the need for more extensive research as iron metabolism disturbances are common in AL and HCT, and hepcidin seems to play a significant role in their modulation.
Article
Multidisciplinary Sciences
Fantian Zeng, Sureya Nijiati, Yangtengyu Liu, Qinqin Yang, Xiaomin Liu, Qianyu Zhang, Shi Chen, Anqi Su, Hehe Xiong, Changrong Shi, Congbo Cai, Zhongning Lin, Xiaoyuan Chen, Zijian Zhou
Summary: An artemisinin-based probe (Art-Gd) was developed for contrast-enhanced magnetic resonance imaging of ferroptosis (feMRI) in anticancer drug-induced acute cardiac/kidney injuries (ACI/AKI). The probe showed great feasibility in early diagnosis of ACI/AKI, providing imaging evidence for the different mechanisms of action of ferroptosis-targeted agents. This study presents a feMRI strategy with simple chemistry and robust efficacy for early evaluation of anticancer drug-induced ACI/AKI.
Article
Chemistry, Physical
Xishao Xie, Yunjing Zhang, Xinwan Su, Junni Wang, Xi Yao, Dou Lv, Qin Zhou, Jianhua Mao, Jianghua Chen, Fei Han, Yangyang Li, Weiqiang Lin
Summary: This study synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles (GGP NPs) as a potential iron-scavenging agent and demonstrated their good biocompatibility and protective effects in inhibiting ferroptosis. Treatment with GGP NPs significantly ameliorated renal injury and mitochondrial damage, making them a potential candidate for AKI treatment.
Article
Chemistry, Multidisciplinary
Ruixue Duan, Yueping Li, Ruru Zhang, Xuelan Hu, Yi Wang, Jianfeng Zeng, Mingyuan Gao
Summary: In this study, ultrasmall Fe3O4 nanoparticles were used as carriers to deliver NMN into renal cells, enhancing mitochondrial function and suppressing inflammation. This approach effectively reversed AKI induced by ischemia reperfusion.
ADVANCED MATERIALS
(2023)
Article
Agriculture, Multidisciplinary
Yunfeng Hou, Shaopeng Wang, Liping Jiang, Xiance Sun, Jing Li, Ningning Wang, Xiaofang Liu, Xiaofeng Yao, Cong Zhang, Haoyuan Deng, Guang Yang
Summary: In this study, researchers found that autophagy-dependent ferroptosis plays a critical role in acute kidney injury induced by PAT. This view was also confirmed in human cell experiments.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, General & Internal
Shu-Min Lin, Chih-Hsiang Chang, Ting-Yu Lin, Allen Chung-Cheng Huang, Chiung-Hung Lin, Yung-Chang Chen, Pao-Hsien Chu
Summary: Cardiorenal syndrome type I (CRS I) is the development of acute kidney injury (AKI) following acute decompensated heart failure (ADHF). This study investigated the association between ADHF and AKI, particularly focusing on the levels of endothelial injury markers. The results showed that higher levels of soluble thrombomodulin (sTM), an endothelial injury marker, were associated with AKI in patients with ADHF. sTM level could potentially be used as a biomarker to predict the development of AKI in ADHF patients.
ANNALS OF MEDICINE
(2022)
Article
Medicine, General & Internal
Francesca Ferrara, Francesca Coppi, Roberta Riva, Paolo Ventura, Andrea Ricci, Anna Vittoria Mattioli, Marisa Talarico, Cinzia Garuti, Mirco Bevini, Vincenzo Rochira, Elena Buzzetti, Antonello Pietrangelo, Elena Corradini
Summary: This study aimed to evaluate the incidence and predictive factors for developing cardiac events in adult β-thalassemia major (TM) and intermedia (TI) patients. The results showed that high LPI levels, low mean pre-transfusion haemoglobin levels, and echocardiographic parameters suggestive of myocardial hypertrophy were associated with cardiac events. LPI may serve as both a prognostic marker and a potential target for novel treatment strategies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Agnieszka Zapora-Kurel, Lukasz Kuzma, Magdalena Zakrzewska, Marcin Zorawski, Slawomir Dobrzycki, Malgorzata Twardowska-Kawalec, Jolanta Malyszko
Summary: The study evaluated the relationship between novel iron parameters and kidney function in patients with type 2 diabetes mellitus. Anemia was common among the studied patients, with the control group showing significantly higher levels of certain biomarkers. Higher eGFR values were associated with higher hemoglobin levels and certain biomarkers, while HIF-1α was primarily related to age in patients with eGFR values >= 60 mL/min/1.73 m(2).
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Lu Zhou, Huirong Li, Jiangtao Hu, Junping Meng, Honghong Lv, Feng Yang, Mengqiu Wang, Rui Liu, Wei Wu, Donghua Hou, Hongbao Liu
Summary: This study analyzed the oxidative lipidomics of plasma from patients with sepsis-associated acute kidney injury (SA-AKI) and identified potential biomarkers and pathophysiological mechanisms involved in SA-AKI.
CLINICA CHIMICA ACTA
(2023)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Chanita Sanyear, Buraporn Chiawtada, Punnee Butthep, Saovaros Svasti, Suthat Fucharoen, Patarabutr Masaratana
Summary: This study found that the inductive effects of LPS on liver IL-6 mRNA expression were more pronounced under parenteral iron loading. Additionally, LPS treatment suppressed FPN1 mRNA expression in thalassemic mice with parenteral iron loading. Despite altered expression of hepcidin regulators, the hypoferremic response to LPS-induced acute inflammation was maintained in a hepcidin-independent manner.
Review
Cardiac & Cardiovascular Systems
Jacek Kubica, Aldona Kubica, Klaudyna Grzelakowska, Wioleta Stolarek, Zofia Grabczewska, Piotr Michalski, Piotr Niezgoda, Stanislaw Bartus, Andrzej Budaj, Mariusz Dabrowski, Jaroslaw Drozdz, Ryszard Gellert, Milosz J. Jaguszewski, Piotr Jankowski, Jacek Legutko, Maciej Lesiak, Przemyslaw Leszek, Jolanta Malyszko, Przemyslaw Mitkowski, Jadwiga Nessler, Krzysztof Pawlaczyk, Jolanta Siller-Matula, Tomasz Stompor, Bogumil Wolnik, Eliano Pio Navarese
Summary: SGLT2 inhibitors improve cardiovascular effects by reducing plasma volume and increasing urinary glucose and sodium excretion, leading to reduced sympathetic activity and preload, and have been widely used in patients with heart failure and chronic kidney disease.
CARDIOLOGY JOURNAL
(2023)
Editorial Material
Transplantation
Michele Farisco, Irene Zecchino, Giovambattista Capasso, CONNECT Consortium
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Oncology
Aleksandra Semeniuk-Wojtas, Arkadiusz Lubas, Aneta Gawin, Maciej Malyszko, Maksymilian Baryla, Rafal Stec, Jolanta Malyszko
Summary: This study retrospectively analyzed the changes in kidney function in cancer patients after undergoing 206 contrast-enhanced computed tomography (CECT) procedures. The results showed that CECT had a negative impact on kidney function, but did not affect oncological treatment. The deterioration of kidney function was associated with the initial creatinine and urea levels of the patients.
ONCOLOGY IN CLINICAL PRACTICE
(2023)
Article
Urology & Nephrology
Michelle A. Josephson, Yolanda Becker, Klemens Budde, Bertram L. Kasiske, Bryce A. Kiberd, Alexandre Loupy, Jolanta Malyszko, Roslyn B. Mannon, Burkhard Toenshoff, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Martin Zeier
Summary: In March 2022, KDIGO held a virtual Controversies Conference to address the often overlooked phase of kidney transplant failure. The conference discussed various aspects related to failing allografts, including prognosis, immunosuppression strategies, management of complications, and choice of treatment options. The conference emphasized the importance of identifying individuals with failing allografts, accurate prognostication tools, psychological preparation and support, and patient involvement in decision-making.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Elaine Ku, Lucia Del Vecchio, Kai-Uwe Eckardt, Volker H. Haase, Kirsten L. Johansen, Masaomi Nangaku, Navdeep Tangri, Sushrut S. Waikar, Andrzej Wiecek, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, David C. Wheeler
Summary: Anemia is common in chronic kidney disease patients and is associated with adverse clinical outcomes. Recent research has focused on hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) as a potential treatment for anemia in these patients.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Rajnish Mehrotra, Sara N. Davison, Ken Farrington, Jennifer E. Flythe, Marjorie Foo, Magdalena Madero, Rachael L. Morton, Yusuke Tsukamoto, Mark L. Unruh, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Edwina A. Brown, Conference Participants
Summary: Patients with kidney failure undergoing maintenance dialysis often experience a high symptom burden that affects functioning and life satisfaction. The focus of nephrology care has traditionally been on laboratory targets and outcomes, with limited attention to symptom assessment and management. A conference was held in May 2022 to address the optimal means for diagnosing and managing symptom-based complications in dialysis patients, outlining foundational principles and identifying research priorities.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Kai -Uwe Eckardt, Cynthia Delgado, Hiddo J. L. Heerspink, Roberto Pecoits-Filho, Ana C. Ricardo, Benedicte Stengel, Marcello Tonelli, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Holly Kramer
Summary: Chronic kidney disease affects a large number of people globally, calling for urgent prevention and management. New tools and interventions, such as biomarkers and artificial intelligence techniques, have emerged to improve the quality and precision of care for CKD. The 2022 KDIGO Controversies Conference discussed best practices and identified knowledge gaps in CKD diagnosis, treatment, and care delivery.
KIDNEY INTERNATIONAL
(2023)
Article
Transplantation
Bartosz Symonides, Jacek Lewandowski, Jolanta Malyszko
Summary: Hypertension is common in chronic kidney disease patients and is a significant risk factor for cardiovascular disease, end-stage kidney disease, and mortality. The current definitions of resistant hypertension do not apply directly to end-stage kidney disease patients. Confirmation of adherence to therapy and confirmation of uncontrolled blood pressure values through ambulatory or home blood pressure measurement are necessary for the diagnosis of true resistant hypertension. The concept of apparent treatment-resistant hypertension has also been introduced. Further research is needed on drug adherence, blood pressure measurement, and defining resistant hypertension in this population.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Aleksandra Golenia, Norbert Zolek, Piotr Olejnik, Pawel Zebrowski, Jolanta Malyszko
Summary: Hemodialysis patients are at a higher risk of cognitive impairment, but the specific affected cognitive domains are still unknown. There is also limited knowledge about the symptoms of depression and anxiety in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Immunology
Jolanta Malyszko, Michal Macech, Malgorzata Kepska-Dzilinska, Slawomir Nazarewski
Article
Medicine, General & Internal
Bartosz Symonides, Jacek Lewandowski, Wojciech Marcinkowski, Jacek Zawierucha, Tomasz Prystacki, Jolanta Malyszko
Summary: This study aimed to assess the prevalence, characteristics, and determinants of apparent treatment-resistant hypertension (aTRH) in a large population of end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD). Prevalence rates of hypertension and aTRH were determined using pre- and post-dialysis blood pressure criteria. The results showed that aTRH in ESKD HD patients appears to be multifactorial, influenced by patient-related factors rather than dialysis-related factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tomasz Glogowski, Ewa Wojtaszek, Jolanta Malyszko
Summary: This study investigated the relationship between peritoneal membrane characteristics, anemia, and inflammation in peritoneal dialysis patients. The complex interplay of several biomarkers of iron status and their association with peritoneal transport, inflammation, and residual renal function were examined. The results showed that residual renal function significantly affects anemia, and peritoneal transport is associated with inflammation and markers of iron status.
FRONTIERS IN MEDICINE
(2023)
Review
Surgery
Joanna Raszeja-Wyszomirska, Michal Macech, Monika Kolanowska, Marek Krawczyk, Slawomir Nazarewski, Anna Wojcicka, Jolanta Malyszko
Summary: This review discusses various types of extracellular DNA (such as cell-free DNA) that circulate in human blood, particularly in inflammatory conditions and organ damage. Cell-free DNA (cfDNA) is considered a valuable additional tool in the post-transplant monitoring of transplant patients, complementing traditional strategies and serving as a risk stratification and prognostic marker. Improved sensitivity and specificity in cfDNA detection are necessary for personalized patient management, and further research is needed in terms of measurement, standardization, and processing.
ANNALS OF TRANSPLANTATION
(2023)
Article
Physiology
Aleksandra Golenia, Norbert Zolek, Piotr Olejnik, Ewa Wojtaszek, Tomasz Glogowski, Jolanta Malyszko
Summary: This study aimed to assess the prevalence of cognitive impairment (CI) and associated factors in patients undergoing peritoneal dialysis (PD). The study found that 33% of PD patients had CI, and that patients aged >= 65 years old were more likely to have CI. Memory and verbal fluency were the most affected cognitive domains in PD patients with CI.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Physiology
Aleksandra Golenia, Piotr Olejnik, Norbert Zolek, Ewa Wojtaszek, Jolanta Malyszko
Summary: This study found that cognitive impairment is common in kidney transplant recipients. Patients with impaired cognition scored significantly lower in all cognitive domains compared to cognitively normal patients. Additionally, better cognitive functioning after transplantation was associated with more years of schooling. Depression and anxiety were also prevalent among some kidney transplant recipients.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)