The protective, rescue and therapeutic potential of multi-target iron-chelators for retinitis pigmentosa

Molecular Mechanisms Related to Oxidative Stress in Retinitis Pigmentosa

(2021) Carla Enrica Gallenga et al.   Antioxidants

Oxidative Stress and Microglial Response in Retinitis Pigmentosa

(2020) Yusuke Murakami et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyclooxygenase-1 mediates neuroinflammation and neurotoxicity in a mouse model of retinitis pigmentosa

(2020) Wei Yang et al.   Journal of Neuroinflammation

Mechanisms of Photoreceptor Death in Retinitis Pigmentosa

(2020) Fay Newton et al.   Genes

ER stress and unfolded protein response in ocular health and disease

(2018) Heike Kroeger et al.   FEBS Journal

Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases

(2018) Gabriel Velez et al.   PLoS One

Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa

(2018) Bin Lin et al.   Cell Death & Disease

Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

(2017) Wenhan Yu et al.   Nature Communications

Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa

(2016) Lijuan Zhang et al.   HUMAN MOLECULAR GENETICS

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

(2016) Ishaq A. Viringipurampeer et al.   HUMAN MOLECULAR GENETICS

Beneficial Effects of Multitarget Iron Chelator on Central Nervous System and Gastrocnemius Muscle in SOD1G93A Transgenic ALS Mice

(2016) Sagit Golko-Perez et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice

(2016) Sagit Golko-Perez et al.   NEUROTOXICITY RESEARCH

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

(2015) Orit Bar-Am et al.   NEUROBIOLOGY OF AGING

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30

(2014) E. Sofic et al.   JOURNAL OF NEURAL TRANSMISSION

Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa

(2014) B. Peng et al.   JOURNAL OF NEUROSCIENCE

Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice

(2014) H. Zeng et al.   NEUROSCIENCE

Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration

(2014) Ke Wang et al.   Scientific Reports

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration

(2013) S Choudhury et al.   Cell Death & Disease

MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration

(2012) Yusuke Murakami et al.   AMERICAN JOURNAL OF PATHOLOGY

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

(2012) Lana Kupershmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Health Services Utilization and Cost of Retinitis Pigmentosa

(2012) Kevin D. Frick et al.   ARCHIVES OF OPHTHALMOLOGY

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice

(2012) Lana Kupershmidt et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice

(2012) Lana Kupershmidt et al.   MOLECULAR NEUROBIOLOGY

Laboratory Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Clinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa

(2011) Alexey Obolensky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer’s disease: a tribute to Moussa Youdim

(2011) Orly Weinreb et al.   JOURNAL OF NEURAL TRANSMISSION

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities

(2010) Orly Weinreb et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30

(2010) Y. Avramovich-Tirosh et al.   Current Alzheimer Research

Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait

(2010) Alan F. Wright et al.   NATURE REVIEWS GENETICS

Coping strategies to manage stress related to vision loss and fluctuations in retinitis pigmentosa

(2010) Ava K. Bittner et al.   OPTOMETRY

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson’s disease

(2009) Makoto Naoi et al.   Expert Review of Neurotherapeutics

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

(2009) Lana Kupershmidt et al.   FASEB JOURNAL

Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration

(2009) Stefanie Ebert et al.   JOURNAL OF NEUROCHEMISTRY

NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa

(2009) Shinichi Usui et al.   JOURNAL OF NEUROCHEMISTRY

Increased Expression of Catalase and Superoxide Dismutase 2 Reduces Cone Cell Death in Retinitis Pigmentosa

(2009) Shinichi Usui et al.   MOLECULAR THERAPY

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

(2009) V. Wee Yong et al.   NEURON

Activation of Bone Marrow-Derived Microglia Promotes Photoreceptor Survival in Inherited Retinal Degeneration

(2008) Manabu Sasahara et al.   AMERICAN JOURNAL OF PATHOLOGY

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

(2008) Sugako Oka et al.   EMBO JOURNAL

Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration

(2008) Javier Sancho-Pelluz et al.   MOLECULAR NEUROBIOLOGY

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE