Article
Pharmacology & Pharmacy
Antolin Canto, Javier Martinez-Gonzalez, Maria Miranda, Teresa Olivar, Inma Almansa, Vicente Hernandez-Rabaza
Summary: Retinitis pigmentosa (RP) is a type of hereditary retinal disease, and inflammation is an important factor. This study found that sulforaphane (SFN) has anti-inflammatory properties and regulates retinal degeneration and inflammation in an RP mouse model. SFN may have neuroprotective effects in clinical settings.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Qun Lu, Chao Huang, Zhiming Cui
Summary: Sinomenine, a natural compound from Sinomenium acutum, has shown beneficial effects in various CNS disorders, including cerebral ischemia, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Its mechanisms of action involve inhibition of oxidative stress, neuroinflammation, and neuronal apoptosis. Sinomenine also exhibits anti-glioma effects and improves morphine dependence and sleep disturbance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Hend Mohamed Hussien, Mokhtar Ibrahim Yousef
Summary: This study aimed to investigate the neuroprotective effect of ginseng extract against neurological and behavior abnormalities induced by cisplatin. The results showed that ginseng extract could alleviate the memory dysfunction and locomotor disability induced by cisplatin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rengasamy Balakrishnan, Ju-Young Park, Duk-Yeon Cho, Jae-Yong Ahn, Dong-Sun Yoo, Sang-Ho Seol, Sung-Hwa Yoon, Dong-Kug Choi
Summary: AD-1 small molecule protects against cognitive decline and memory impairment induced by oxidative brain damage, by inhibiting AChE activity, reducing oxidant factors, alleviating neuroinflammation and neuronal apoptosis. It also increases the expression of neuroprotective markers and improves spatial learning behavior and memory formation.
Article
Neurosciences
Qiang Huang, Jun Ying, Wen Yu, Yao Dong, Hao Xiong, Yiping Zhang, Jie Liu, Xifeng Wang, Fuzhou Hua
Summary: Alzheimer's disease is a major cause of age-related dementia and its pathogenesis and etiology are not fully understood. P2X7R has been identified as a potential key player in the development of Alzheimer's disease, suggesting potential pharmacological interventions to slow down disease progression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia Di Benedetto, Chiara Burgaletto, Maria Francesca Serapide, Rosario Caltabiano, Antonio Munafo, Carlo Maria Bellanca, Rosaria Di Mauro, Renato Bernardini, Giuseppina Cantarella
Summary: This study demonstrates the significant role of TRAIL-R2 in Aβ-related neurodegeneration and provides further evidence that the TRAIL system is a potential target for innovative AD therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Khalaf F. Alsharif, Ashraf Albrakati, Naif E. Al Omairi, Abdulraheem S. Almalki, Walaa F. Alsanie, Zakaria Y. Abd Elmageed, Ola A. Habotta, Maha S. Lokman, Hussam A. Althagafi, Abdullah A. A. Alghamdi, Ahmed E. Abdel Moneim, Hussain Alyami, Saied K. M. Belal, Ghaliah Alnefaie, Abdulhakeem S. Alamri, Nisreen Khalid Aref Albezrah, Rami B. Kassab, Alaa Jameel A. Albarakati, Khalid Ebraheem Hassan, Ahmad Agil
Summary: The combined administration of prodigiosin (PDG) and selenium (Na2SeO3) has shown promising therapeutic effects in a rat model of schizophrenia induced by amphetamine. The treatment improved social interaction, decreased acetylcholinesterase (AChE) and dopamine levels, and modulated the expression of NMDAR1 and neurotrophic factors. It also enhanced antioxidant defense, reduced neuroinflammation and apoptosis, resulting in significant improvements in schizophrenia-related symptoms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaolan Xie, Zhiwen Shen, Chuwen Hu, Kun Zhang, Mingyan Guo, Fei Wang, Kai Qin
Summary: Research indicates that Dexmedetomidine may have neuroprotective effects against surgery-induced cognitive impairment through its anti-inflammatory and antioxidant properties, as well as the suppression of the mitochondrial permeability transition pore and apoptosis-related pathway.
NEUROCHEMICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Demet Sinem Guden, Meryem Temiz-Resitoglu, Sefika Pinar Senol, Deniz Kibar, Sakir Necat Yilmaz, Bahar Tunctan, Kafait U. Malik, Seyhan Sahan-Firat
Summary: This study investigated the effects of mTOR inhibition by rapamycin on inflammation, microglial activation, oxidative stress, and apoptosis associated with a systemic challenge with LPS, revealing its regulation of the inflammatory response via the IKB-alpha/NF-kappa B/HIF-1 alpha signaling pathway.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Neurosciences
Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: The study suggests a link between anxiety disorders and sleep deprivation, with melatonin supplementation showing potential in ameliorating the effects. Melatonin was found to attenuate anxiety-like behaviors induced by sleep deprivation by improving oxidative stress, NF-kappa B pathway activation, neuroinflammation, apoptosis, and excessive autophagy.
BRAIN RESEARCH BULLETIN
(2021)
Review
Cell Biology
Ana Maria Buga, Vlad Padureanu, Anca-Lelia Riza, Carmen Nicoleta Oancea, Carmen Valeria Albu, Alexandru Dan Nica
Summary: The central nervous system (CNS) is highly vulnerable to oxidative stress, which is mainly triggered by the gut microbiota. This oxidative damage leads to mitochondrial dysfunction, neuroinflammation, and neurodegeneration. Recent studies have shown the importance of the gut-brain axis in mediating oxidative-stress-related inflammation in multiple sclerosis (MS), and targeting the gut microbiota could be a promising strategy for MS management. However, further clinical trials with larger cohorts are needed to validate the proposed interventions.
Article
Nutrition & Dietetics
Yang Li, Miao Sun, Fuyang Cao, Yu Chen, Linlin Zhang, Hao Li, Jiangbei Cao, Jie Song, Yulong Ma, Weidong Mi, Xiaoying Zhang
Summary: The study found that the ferroptosis inhibitor liproxstatin-1 can ameliorate inflammation-related cognitive impairment by reducing the release of inflammatory mediators and oxidative stress, and by regulating iron metabolism and iron ferroptosis-related proteins.
Review
Chemistry, Applied
Zhiyuan Zhang, Shuai Wang, Haining Tan, Pei Yang, Yuanyuan Li, Lingchuan Xu, Baoguo Duan, Yuhong Liu
Summary: This paper reviews recent research on the regulation of natural polysaccharides in Alzheimer's disease (AD) and systematically lists possible intervention pathways of polysaccharides targeting different mechanisms.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Tingting Liu, Xiaolei Zhu, Chaoli Huang, Jiang Chen, Shu Shu, Guiquan Chen, Yun Xu, Yimin Hu
Summary: The study shows that PP2A is critical for neuronal survival and inhibition of ERK may be an effective strategy to reduce cell death in brain diseases.
Article
Food Science & Technology
Lin Cong, Meng-Yu Lei, Zhi-Qi Liu, Zhuo-Fan Liu, Zhuo Ma, Kuan Liu, Jing Li, Yu Deng, Wei Liu, Bin Xu
Summary: The findings suggest that resveratrol alleviates manganese-induced oxidative stress and neuroinflammation in adult mice by activating SIRT1 signaling.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Cell Biology
Jia Xiao, Yi Lv, Bin Lin, George L. Tipoe, Moussa B. H. Youdim, Feiyue Xing, Yingxia Liu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2015)
Article
Multidisciplinary Sciences
Ti-Fei Yuan, Yu-Xiang Liang, Bo Peng, Bin Lin, Kwok-Fai So
SCIENTIFIC REPORTS
(2015)
Article
Multidisciplinary Sciences
Hei Ming Lai, Alan King Lun Liu, Wai-Lung Ng, John DeFelice, Wing Sang Lee, Heng Li, Wen Li, Ho Man Ng, Raymond Chuen-Chung Chang, Bin Lin, Wutian Wu, Steve M. Gentleman
Article
Ophthalmology
Ming-Ming Liu, Jia-Man Dai, Wen-Yi Liu, Cong-Jian Zhao, Bin Lin, Zheng-Qin Yin
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Neurosciences
Ke Wang, Bo Peng, Bin Lin
Article
Neurosciences
Bo Peng, Jia Xiao, Ke Wang, Kwok-Fai So, George L. Tipoe, Bin Lin
JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Rui Guo, Bin Lin, Jing Fei Pan, Emily C. Liong, Ai Min Xu, Moussa Youdim, Man Lung Fung, Kwok Fai So, George L. Tipoe
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Bin Lin, Guoyin Xiong, Wei Yang
CELL DEATH & DISEASE
(2018)
Article
Immunology
Wei Yang, Guoyin Xiong, Bin Lin
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Cell Biology
Wang Sheng, Da Lv, Ze-Kai Cui, Yi-Ni Wang, Bin Lin, Shi-Bo Tang, Jian-Su Chen
Summary: The study demonstrates that gamma-flicker light (gamma FL) can improve retinal aging in aged mice by reducing senescence-associated beta-galactosidase positive cells, diminishing lipofuscin accumulation, and ameliorating expression imbalance of certain proteins. Additionally, gamma FL exerts its effects on retinal aging through various mechanisms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhang, Jiangmei Wu, Daqian Lu, Chi-Ho To, Thomas Chuen Lam, Bin Lin
Summary: This study investigated the changes in the retinal proteomic profile in the EIU mouse model using mass spectrometry analysis. The study identified differentially expressed proteins related to uveitis and acute retinal inflammation, and identified important pathways associated with these conditions. These findings provide potential candidates for exploring the mechanism and novel therapeutic targets for uveitis and other retinal inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin
Summary: TPM1 plays a crucial role in regulating pro-inflammatory phenotype of microglia, mediating LPS-induced inflammation through the PKA/CREB signaling pathway. TPM1 also regulates inflammation downstream of TREM2 and in a microglia-dependent manner.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Ophthalmology
Ke Wang, Bo Peng, Jia Xiao, Orly Weinreb, Moussa B. H. Youdim, Bin Lin
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Ophthalmology
Xiaotao Li, Chaoran Ren, Lu Huang, Bin Lin, Mingliang Pu, Gary E. Pickard, Kwok-Fai So
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)