NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

The anti-inflammatory effects of acetaminophen and N-acetylcysteine through suppression of the NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

(2015) Yu Liu et al.   Innate Immunity

Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells

(2014) Tomohisa Yokoyama et al.   Autophagy

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors

(2014) Olga S. Sizova et al.   CELLULAR SIGNALLING

Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

(2014) Leah C. Byrne et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects

(2014) Agustina Noailles et al.   Journal of Neuroinflammation

Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control

(2014) Beatriz Sangiuliano et al.   MEDIATORS OF INFLAMMATION

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration

(2014) Wei-Chieh Chiang et al.   MOLECULAR NEUROBIOLOGY

Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa

(2014) Adeseye Adekeye et al.   PLoS One

Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration

(2014) Blanca Arango-Gonzalez et al.   PLoS One

An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina

(2014) T Rana et al.   Cell Death & Disease

The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa

(2014) D A Parfitt et al.   Cell Death & Disease

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

Microglia and Interleukin-1β in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A

(2013) José Carlos Rivera et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

(2013) Y Murakami et al.   CELL DEATH AND DIFFERENTIATION

Histones trigger sterile inflammation by activating the NLRP3 inflammasome

(2013) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Receptor Interacting Protein Kinase-Mediated Necrosis Contributes to Cone and Rod Photoreceptor Degeneration in the Retina Lacking Interphotoreceptor Retinoid-Binding Protein

(2013) K. Sato et al.   JOURNAL OF NEUROSCIENCE

P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia

(2013) Rachael Bartlett et al.   MEDIATORS OF INFLAMMATION

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Clinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

(2012) Noriko Yoshida et al.   OPHTHALMOLOGY

Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

(2012) Y. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Mechanisms of Photoreceptor Degeneration in a New Mouse Model of the Common Form of Autosomal Dominant Retinitis Pigmentosa due to P23H Opsin Mutations

(2011) Sanae Sakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats

(2011) Jasvir Kaur et al.   PLoS One

The Inflammasomes

(2010) Kate Schroder et al.   CELL

N-acetylcysteine promotes long-term survival of cones in a model of retinitis pigmentosa

(2010) Sun Young Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

(2010) M. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Junín Virus Infection of Human Hematopoietic Progenitors Impairs In Vitro Proplatelet Formation and Platelet Release via a Bystander Effect Involving Type I IFN Signaling

(2010) Roberto G. Pozner et al.   PLoS Pathogens

Retinal metabolic state of the proline-23-histidine rat model of retinitis pigmentosa

(2009) Monica L. Acosta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Molecular Mechanisms and Pathophysiology of Necrotic Cell Death

(2008) Nele Vanlangenakker et al.   CURRENT MOLECULAR MEDICINE

Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa

(2008) Hugo F. Mendes et al.   HUMAN MOLECULAR GENETICS

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE