Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation

Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

(2021) Tian Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson's disease: The therapeutic role of Nrf2 activators

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Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo

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Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

(2020) Yao Wei et al.   Nature Communications

Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating ERK1/2/Nrf2/HO-1 pathway

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Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway

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Promotion of Mitochondrial Protection by Emodin in Methylglyoxal-Treated Human Neuroblastoma SH-SY5Y Cells: Involvement of the AMPK/Nrf2/HO-1 Axis

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Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice

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Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1–Nrf2–ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo

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Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR‐338‐3p/PKM2 Axis Under Hypoxic Stress

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Xanthohumol Analogues as Potent Nrf2 Activators against Oxidative Stress Mediated Damages of PC12 Cells

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Nitric oxide maintains endothelial redox homeostasis through PKM 2 inhibition

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Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells

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PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

(2018) Binbin Wang et al.   JOURNAL OF HEADACHE AND PAIN

Emodin protects hyperglycemia-induced injury in PC-12 cells by up-regulation of miR-9

(2018) Lei Fan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Combined Use of Emodin and Ginsenoside Rb1 Exerts Synergistic Neuroprotection in Cerebral Ischemia/Reperfusion Rats

(2018) Yan Li et al.   Frontiers in Pharmacology

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect

(2017) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

A threshold of transmembrane potential is required for mitochondrial dynamic balance mediated by DRP1 and OMA1

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Health, social and economic consequences of dementias: a comparative national cohort study

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Nrf2 Transcription Factor Can Directly Regulate mTOR

(2016) Gabriel Bendavit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

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AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

(2016) Xiaoxv Dong et al.   PHYTOTHERAPY RESEARCH

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Protection of vascular endothelial cells from high glucose-induced cytotoxicity by emodin

(2015) Yun Gao et al.   BIOCHEMICAL PHARMACOLOGY

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

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Vitamin D3potentiates the growth inhibitory effects of metformin in DU145 human prostate cancer cells mediated by AMPK/mTOR signalling pathway

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Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells

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Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents

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Ferulic Acid Protects Against Lead Acetate-Induced Inhibition of Neurite Outgrowth by Upregulating HO-1 in PC12 Cells: Involvement of ERK1/2-Nrf2 Pathway

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Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

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Overexpression of MicroRNA-122 Re-sensitizes 5-FU-Resistant Colon Cancer Cells to 5-FU Through the Inhibition of PKM2 In Vitro and In Vivo

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Effect of Tacrine-3-caffeic Acid, A Novel Multifunctional Anti-Alzheimer's Dimer, Against Oxidative-Stress-Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO-1 Pathway

(2014) Xiao-Juan Chao et al.   CNS Neuroscience & Therapeutics

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Design, Synthesis, and Biological Evaluation of (E)-3,4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents

(2014) Xianling Ning et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo

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Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Emerging roles of PKM2 in cell metabolism and cancer progression

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Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation

(2010) David G. I. Kingston   JOURNAL OF NATURAL PRODUCTS

Thioredoxin and Cancer: A Role for Thioredoxin in all States of Tumor Oxygenation

(2010) Therese Christina Karlenius et al.   Cancers

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY