PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain

(2017) Yuanyuan Ding et al.   JOURNAL OF HEADACHE AND PAIN

Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats

(2017) Baisong Zhao et al.   JOURNAL OF HEADACHE AND PAIN

CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization

(2017) Rangel L. Silva et al.   NEUROBIOLOGY OF DISEASE

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

(2017) Smriti Iyengar et al.   PAIN

PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer

(2017) Chao Wang et al.   Scientific Reports

Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders

(2016) Mithilesh Kumar Jha et al.   BIOCHEMICAL PHARMACOLOGY

Evolving Insights into the Pathophysiology of Diabetic Neuropathy: Implications of Malfunctioning Glia and Discovery of Novel Therapeutic Targets

(2016) Md Habibur Rahman et al.   CURRENT PHARMACEUTICAL DESIGN

Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy

(2016) Md Habibur Rahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contributions of p38 and ERK to the antinociceptive effects of TGF-β1 in chronic constriction injury-induced neuropathic rats

(2016) Nan-Fu Chen et al.   JOURNAL OF HEADACHE AND PAIN

Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats

(2016) Wei Di et al.   JOURNAL OF HEADACHE AND PAIN

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension

(2016) Dongqing Guo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer

(2015) Peng Yang et al.   CELLULAR SIGNALLING

Pyruvate kinase M2 at a glance

(2015) W. Yang et al.   JOURNAL OF CELL SCIENCE

Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis

(2015) M. K. Jha et al.   JOURNAL OF NEUROSCIENCE

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Sensory Neurons, Ion Channels, Inflammation and the Onset of Neuropathic Pain

(2014) Patrick L. Stemkowski et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

(2014) Kirstie E. Keller et al.   MOLECULAR CELL

Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice

(2014) Qian Zhang et al.   MOLECULAR NEUROBIOLOGY

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fractalkine/CX3CR1 signaling during neuropathic pain

(2014) Anna K. Clark et al.   Frontiers in Cellular Neuroscience

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals

(2013) Xueliang Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

Chemokines and cytokines in neuroinflammation leading to neuropathic pain

(2011) Norikazu Kiguchi et al.   CURRENT OPINION IN PHARMACOLOGY

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

The Role of Glia and the Immune System in the Development and Maintenance of Neuropathic Pain

(2010) Ricardo Vallejo et al.   Pain Practice

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Cytokine regulation in animal models of neuropathic pain and in human diseases

(2008) Nurcan Üçeyler et al.   NEUROSCIENCE LETTERS