Article
Food Science & Technology
Zhenjiang Ding, Hong Hong Da, Alsiddig Osama, Junmin Xi, Yanan Hou, Jianguo Fang
Summary: The study reveals that emodin can resist mitochondrial fission and apoptosis caused by oxidative stress in neuronal cells, and the activation of the PKM2/Nrf2/ARE axis plays a crucial role in this process.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vy Ngo, Martin L. L. Duennwald
Summary: Oxidative stress is associated with major human diseases, and the transcription factor Nrf2 plays a key role in the antioxidant defense system and has been extensively studied in disease contexts.
Article
Biochemistry & Molecular Biology
Domenico Nuzzo, Pasquale Picone, Costanza Giardina, Miriana Scordino, Giuseppa Mudo, Mario Pagliaro, Antonino Scurria, Francesco Meneguzzo, Laura M. Ilharco, Alexandra Fidalgo, Rosa Alduina, Alessandro Presentato, Rosaria Ciriminna, Valentina Di Liberto
Summary: The Lemon IntegroPectin obtained through hydrodynamic cavitation of organic lemon waste has shown significant neuroprotective activity in vitro, highlighting the potential for further research on its efficacy in preventing, delaying, or even curing neurological diseases.
Article
Food Science & Technology
Li Feng, Yingmin Wu, Jiankang Wang, Yuting Han, Junrong Huang, Huaide Xu
Summary: In this study, the neuroprotective effects of SGGY on H2O2-induced oxidative stress in SH-SY5Y cells were investigated. Results showed that SGGY alleviated oxidative stress by reducing ROS levels and altering MMP, thereby promoting cell survival and inhibiting apoptosis. SGGY also restored antioxidant enzyme activities, suppressed the activation of MAPKs, and facilitated the nuclear translocation of Nrf2. Overall, these findings suggest that SGGY protects against oxidative stress by enhancing antioxidant defense and modulating MAPK and Nrf2 signaling pathways.
Article
Biochemistry & Molecular Biology
Zengxin Qi, Yusheng Tong, Hao Luo, Ming Chen, Nan Zhou, Liang Chen
Summary: Oxidative stress has a close relationship with cerebral ischemic/reperfusion (I/R) injury. The Keap1-Nrf2 pathway is a defensive system to maintain cellular redox homeostasis. In this study, compound 6 K was found to be a promising antioxidant treatment for cerebral I/R injury through activation of Nrf2 and suppression of oxidative stress.
BIOORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Neelum Iqbal, Hafiz Muhammad Zubair, Mikhlid H. Almutairi, Muhammad Abbas, Muhammad Furqan Akhtar, Lotfi Aleya, Mohamed Kamel, Ammara Saleem, Qaiser Jabeen, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Mohamed M. Abdel-Daim
Summary: Cordia rothii Roem. & Schult. possesses strong antioxidant and hepatoprotective activities, which may involve the Nrf2-NF kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Shaofeng Wu, Gan Rao, Rui Wang, Qiling Pang, Xiaoyong Zhang, Riming Huang, Taotao Li, Zhaoxin Tang, Lianmei Hu
Summary: The study found that arsenic trioxide exposure can be harmful to the growth and nervous system of ducks, while curcumin can alleviate oxidative stress, inflammatory response, and blood-brain barrier injury caused by ATO exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi
Summary: ROS play a crucial role in cellular processes, with Keap1-Nrf2 pathway acting as a master antioxidant mechanism. While activation of Nrf2 benefits cells in early stages by reducing ROS levels, hyperactivation can support the survival of healthy and cancer cells against oxidative stress and treatments. Understanding the dual role of Nrf2 in cancer cells can be important in cancer treatment strategies.
Article
Pharmacology & Pharmacy
Ibrahim Bulama, Suleiman Nasiru, Abubakar Bello, Abdullahi Yahaya Abbas, Jinjiri Ismail Nasiru, Yusuf Saidu, Musa Samaila Chiroma, Mohamad Aris Mohd Moklas, Che Norma Mat Taib, Ali Waziri, Bilbis Lawal Suleman
Summary: This study evaluated the antioxidative neuroprotective property and learning and memory-enhancing effects of dimethyl sulfoxide (DMSO) in a rat model after traumatic brain injury (TBI). The results showed that DMSO improved learning and memory, locomotor function, and decreased anxiety in rats with induced TBI. Additionally, DMSO decreased oxidative stress and S100B levels, while increasing the activity of antioxidant enzymes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hai-Ping Gu, Xiao-Feng Wu, Ya-Ting Gong, Mu-Yao Wu, Meng-Ying Shi, Ya-ming Sun, Bao-Qi Dang, Gang Chen
Summary: The role of HDAC3 in surgical brain injury (SBI) was studied and it was found that inhibiting HDAC3 can reduce oxidative stress and neuronal apoptosis, thereby reducing brain edema and protecting against nerve injury.
Review
Biochemistry & Molecular Biology
Paolo Tucci, Roberta Lattanzi, Cinzia Severini, Luciano Saso
Summary: In this review, we present the scientific literature supporting the role of nuclear transcription factor-2 (Nrf2) in Huntington's disease (HD) and the potential prophylactic and therapeutic role of this compound.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Wenlong Hao, Minghao Li, Qingmin Cai, Shiying Wu, Xiangyao Li, Quanyu He, Yongbin Hu
Summary: This review discusses the KEAP1/NRF2 signaling mechanisms and recent advances in understanding the role of NRF2 in primary fibrotic lesions. It also explores the therapeutic potential of antioxidant substances and drugs and summarizes the prospects of NRF2 in fibrosis treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Syed Shams Ul Hassan, Saptadip Samanta, Raju Dash, Tomasz M. Karpinski, Emran Habibi, Abdul Sadiq, Amirhossin Ahmadi, Simona Bungau
Summary: Fisetin, a flavonoid compound, exhibits potent antioxidant properties and protects cells against oxidative stress, reducing the risk of neuroinflammation and neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sereen Sandouka, Tawfeeq Shekh-Ahmad
Summary: Sulforaphane, a naturally occurring Nrf2 activator, demonstrates neuroprotective effects in epilepsy pathology by reducing ROS generation, restoring antioxidant levels, and preventing neuronal cell death.
Article
Oncology
Juhui Qiao, Yuchu Zhao, Ying Liu, Siyu Zhang, Wenxue Zhao, Shichao Liu, Meichen Liu
Summary: This study investigated the neuroprotective effects of active components of ginseng and their mechanisms in two models of Parkinson's disease. The results showed that ginsenoside Re protected neurons against mitochondrial dysfunction and oxidative damage induced by Rot. This protection was mediated through activation of the Nrf2 pathway and the PI3K/AKT and ERK pathways.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Chemistry, Medicinal
Junmin Zhang, Dongzhu Duan, Zi-Long Song, Tianyu Liu, Yanan Hou, Jianguo Fang
Summary: Regulating intracellular ROS levels may be an effective strategy for cancer prevention or treatment. This can be achieved through chemoprevention to reduce ROS production pathways, or through ROS-mediated anticancer therapy to stimulate ROS clearance, ultimately inhibiting tumor growth.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Guodong Hu, Miao Zhong, Jintao Zhao, Hao Gao, Lu Gan, Hong Zhang, Shengxiang Zhang, Jianguo Fang
Summary: Cellular redox homeostasis is primarily regulated by the ratio of thiols and disulfides, with reversible thioldisulfide exchange reactions being crucial. Detecting protein disulfides (PDS) poses challenges due to dynamic exchanges of thiols and disulfides. Researchers have designed a probe that selectively recognizes PDS in live organisms, revealing an increase of PDS in mouse brains of a stroke model.
Article
Biochemistry & Molecular Biology
Yanan Hou, Jie Li, Jun-Chen Wu, Quan-Xiang Wu, Jianguo Fang
Summary: Seven dibenzopyrone phenolic derivatives were isolated from endophytic fungi Alternaria alternata extract, with compound 3 determined as a new compound. Compounds 3, 4, 6, and 7 showed significant neuroprotective effects in PC12 cells through activating Nrf2, promoting the expression of Nrf2-governed genes, and enhancing cellular antioxidant capacity. The genetic silence of Nrf2 expression eliminated the observed cytoprotection, emphasizing the crucial role of Nrf2 in the protection offered by these compounds.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Plant Sciences
Yaling Hui, Ting Tang, Jing Wang, Huanhuan Zhao, Hong-Ying Yang, Junmin Xi, Baoxin Zhang, Jianguo Fang, Kun Gao, Yueting Wu
Summary: The study isolated a natural product FDC from an endophytic fungus of Lycium barbarum, which significantly inhibited proliferation in various human NSCLC cell lines through binding to intracellular iron to induce apoptosis.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Agriculture, Multidisciplinary
Zhenjiang Ding, Junmin Xi, Miao Zhong, Fan Chen, Huanhuan Zhao, Baoxin Zhang, Jianguo Fang
Summary: The research demonstrates that CYN inhibits PKM2 activity and induces cell cycle arrest, oxidative stress, and mitochondrial damage. However, overexpression of PKM2 attenuates the effects of CYN on cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Jintao Zhao, Zihua Wang, Miao Zhong, Qianhe Xu, Xinming Li, Bingbing Chang, Jianguo Fang
Summary: In this study, a diselenide/disulfide unit was introduced into camptothecin, leading to the identification of two selenoprodrugs with improved efficacy in treating cancer. These selenoprodrugs can be activated by glutathione, accompanied by the generation of selenol intermediates that catalyze oxidation reactions. The discovery of the fluorescence quenching property of the diselenide/disulfide bond provides insights into developing novel theranostic agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Zi-Long Song, Junmin Zhang, Qianhe Xu, Danfeng Shi, Xiaojun Yao, Jianguo Fang
Summary: The study prepared different amino-substituted phenylarsine oxides and found that the o-substituted molecule exhibited higher potency in inhibiting cellular TrxR activity, leading to oxidative stress-mediated apoptosis. These findings suggest the promising potential of TrxR inhibitors as cancer therapeutic agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Lanning Zhao, Yuan Qu, Fang Zhang, Di Ma, Hao Gao, Lu Gan, Hong Zhang, Shengxiang Zhang, Jianguo Fang
Summary: We report a versatile thiol-triggered fluorogenic release system that can rapidly release a molecule of interest and has been validated for its therapeutic potential in live cells and animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Zi-Long Song, Lanning Zhao, Tao Ma, Alsiddig Osama, Tong Shen, Yilin He, Jianguo Fang
Summary: This review categorizes and describes H2S donors and comprehensively discusses their release mechanisms, biological applications, and therapeutic values. It also analyzes the drawbacks of typical H2S donors and proposes future development directions.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Agriculture, Multidisciplinary
Xiao-Wei Guo, Zhen-Qing Yu, Junmin Xi, Hao Ren, Xin-Yu Xiang, Jia Wu, Jianguo Fang, Quan-Xiang Wu
Summary: Sixteen new polyketides, including four novel carbon skeletons, were isolated from an endophytic fungus. The structures of these polyketides were determined using X-ray diffraction analysis and electric circular dichroism spectra comparison. The polyketides showed low toxicity and exhibited excellent antioxidant activity, with one compound showing greater efficacy than resveratrol in scavenging free radicals. These findings suggest that the novel polyketides could be potential antioxidant agents for neuroprotection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Analytical
Fang Zhang, Fan Chen, Ruipeng Shen, Ya-xiong Chen, Zhengjia Zhao, Baoxin Zhang, Jianguo Fang
Summary: This study reports the construction of a probe library based on the naphthalimide skeleton to detect glutathione (GSH). Compound R13 was identified as a highly efficient GSH fluorescent probe and could be used to quantify GSH in cells and tissues. The probe was applied to study the alteration of GSH level in mouse livers after X-ray irradiation and Parkinson's mouse brains, providing valuable insights into the fluctuation of GSH/GSSG ratio in diseases.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Fan Chen, Baoxin Zhang, Zhenjiang Ding, Miao Zhong, Yanan Hou, Fang Zhang, Guodong Hu, Jianguo Fang
Summary: We report a new fluorescent probe, RBH, for imaging HO-1 activity in live cells, utilizing hemin as a universal static quencher. RBH has favorable properties such as long excitation/emission wavelengths, fast response rate, and high signal increase, enabling its use for determining HO-1 activity in complex biological samples. The discovery of hemin as a general static dark quencher provides a straightforward strategy for constructing novel fluorescent probes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Fang Zhang, Fan Chen, Miao Zhong, Ruipeng Shen, Zhengjia Zhao, Haopai Wei, Baoxin Zhang, Jianguo Fang
Summary: This study reports a fluorescent probe for detecting carbonic anhydrases (CAs), which demonstrates excellent selectivity, favorable biocompatibility, and desirable blood-brain barrier (BBB) penetration. The probe enables imaging of CA fluctuations in cells and mice, providing insights into the role of CA in disease pathogenesis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lanning Zhao, Feifei Bai, Fan Chen, Menghuan Guo, Lu Gan, Hong Zhang, Jianguo Fang
CHEMICAL COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Junmin Zhang, Zai-Qin Zheng, Qianhe Xu, Ya Li, Kun Gao, Jianguo Fang
Summary: The study identifies a new natural product, onopordopicrin (ONP), which inhibits thioredoxin reductase leading to disruption of cellular redox balance and promotion of oxidative stress. ONP shows the highest potency in killing cancer cells, with its inhibitory effect on TrxR closely correlated with cytotoxicity.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
