Diet‐derived ergothioneine induces necroptosis in colorectal cancer cells by activating the SIRT3/MLKL pathway

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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MLKL in cancer: more than a necroptosis regulator

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Histone Deacetylases and their Inhibitors in Colorectal Cancer Therapy: Current Evidence and Future Considerations

(2021) Nikolaos Garmpis et al.   CURRENT MEDICINAL CHEMISTRY

Colorectal Cancer Apoptosis Induced by Dietary δ-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3

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Prospective study of dietary mushroom intake and risk of mortality: results from continuous National Health and Nutrition Examination Survey (NHANES) 2003-2014 and a meta-analysis

(2021) Djibril M. Ba et al.   Nutrition Journal

Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway

(2021) Aminah G. Alotaibi et al.   TOXICOLOGY

SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells

(2021) Nunzia D’Onofrio et al.   Cancers

Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut

(2020) Nadine Mikuda et al.   JOURNAL OF PATHOLOGY

ROS-Mediated Apoptotic Cell Death of Human Colon Cancer LoVo Cells by Milk δ-Valerobetaine

(2020) Nunzia D’Onofrio et al.   Scientific Reports

Vitamin C and Cell Death

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Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

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The multifaceted role of TRAIL signaling in cancer and immunity

(2020) Ludmila Cardoso Alves et al.   FEBS Journal

ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals

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Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

(2019) Meng Li et al.   CANCER CELL

Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective

(2019) Hugo P. Monteiro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

(2019) Einar Smith et al.   HEART

SLC22A5 (OCTN2) Carnitine Transporter—Indispensable for Cell Metabolism, a Jekyll and Hyde of Human Cancer

(2019) Barbara Juraszek et al.   MOLECULES

Substrate Selectivity Check of the Ergothioneine Transporter

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Integrative expression quantitative trait locus–based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression

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Ergothioneine - a diet-derived antioxidant with therapeutic potential

(2018) Barry Halliwell et al.   FEBS LETTERS

Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues

(2018) Richard Ming Yi Tang et al.   Scientific Reports

Insane in the membrane: a structural perspective of MLKL function in necroptosis

(2017) Emma J Petrie et al.   IMMUNOLOGY AND CELL BIOLOGY

Ergothioneine Antioxidant Function

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Impairment of the carnitine/organic cation transporter 1–ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease

(2017) Yasuyuki Shinozaki et al.   KIDNEY INTERNATIONAL

Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

(2016) Irwin K. Cheah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of necroptosis signaling and cell death by reactive oxygen species

(2016) Simone Fulda   BIOLOGICAL CHEMISTRY

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6

(2016) Nunzia D’Onofrio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

(2016) Xian Li et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

An uncommon redox behavior sheds light on the cellular antioxidant properties of ergothioneine

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Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice

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Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

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IL-32γ enhances TNF-α-induced cell death in colon cancer

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Targeting IAP proteins for therapeutic intervention in cancer

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Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

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Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

(2011) Maurizio Martini et al.   INFLAMMATORY BOWEL DISEASES

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

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Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

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Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

(2008) M. Okabe et al.   MOLECULAR CANCER THERAPEUTICS

Ergothioneine Modulates Proinflammatory Cytokines and Heat Shock Protein 70 in Mesenteric Ischemia and Reperfusion Injury

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