Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms

Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity

(2021) Jin-Ping Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors

(2021) Jie Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation

(2021) Vijai Kumar Reddy Tangadanchu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus

(2021) Juan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel carbazole-oxadiazoles as potential Staphylococcus aureus germicides

(2021) Yun-Peng Xie et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles

(2020) Yan-Fei Sui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acetaldehyde-induced oxidative modifications and morphological changes in isolated human erythrocytes: an in vitro study

(2020) Sana Waris et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Oxadiazolylthiazoles as novel and selective antifungal agents

(2020) Mohamed Hagras et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane

(2020) Tingting Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole Compounds as Antiviral Agents: An Update

(2020) Inder P. Singh et al.   Medicinal Chemistry

Tracing the Origin of Invasive Fungal Infections

(2020) Nicolas Papon et al.   TRENDS IN MICROBIOLOGY

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal

(2020) Sofia Costa-de-Oliveira et al.   Microorganisms

Recent Advances in Fluorescent Probes for Detection of HOCl and HNO

(2020) Anila Hoskere Ashoka et al.   ACS Omega

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

(2020) Yunjin Lee et al.   CHEMICAL REVIEWS

Synthesis of 6‐[4‐(4‐Propoxyphenyl)piperazin‐1‐yl]‐9 H ‐purine Derivatives as Antimycobacterial and Antifungal Agents: In Vitro Evaluation and In Silico Study

(2020) Afra Quasar A. Nadaf et al.   CHEMISTRY & BIODIVERSITY

An overview of piperazine scaffold as promising nucleus for different therapeutic targets

(2020) Anjali Sharma et al.   CURRENT PHARMACEUTICAL DESIGN

Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis

(2020) Guiyan Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

(2020) James K. Martin et al.   CELL

Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

(2020) Rostom Ahmed-Belkacem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators

(2020) Yuan-Yuan Hu et al.   Future Medicinal Chemistry

Synthesis and Biological Evaluation of Quinazolonethiazoles as New Potential Conquerors towards Pseudomonas Aeruginosa

(2020) Jie Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Microwave-assisted aqueous two-phase extraction of phenolic compounds from Ribes nigrum L. and its antibacterial effect on foodborne pathogens

(2020) Meimei Zhao et al.   FOOD CONTROL

Sulfonamide-derived Four-component Molecular Hybrids as Novel DNA-targeting Membrane Active Potentiators against Clinical Escherichia coli

(2019) Yuan-Yuan Hu et al.   MOLECULAR PHARMACEUTICS

Twenty Years of the SENTRY Antifungal Surveillance Program: Results for Candida Species From 1997–2016

(2019) Michael A Pfaller et al.   Open Forum Infectious Diseases

Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

(2019) Xiang Liu et al.   COORDINATION CHEMISTRY REVIEWS

Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus

(2019) Chun-Fang Hu et al.   BIOORGANIC CHEMISTRY

Combining proteomics and lipid analysis to unravel Confidor stress response in Saccharomyces cerevisiae

(2019) Iva Justinić et al.   ENVIRONMENTAL TOXICOLOGY

A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus

(2019) Zhen-Zhen Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antifungal activity of different essential oils against Malassezia pathogenic species

(2019) Rosa Donato et al.   JOURNAL OF ETHNOPHARMACOLOGY

Structure–Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

(2019) Rachel D. Slack et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Chemistry of Drugs to Treat Candida albicans

(2019) Aurelio Ortiz et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove

(2018) Ya-Nan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Benzimidazole-Quinolone Hybrids as New Cleaving Agents toward Drug-Resistant Pseudomonas aeruginosa DNA

(2018) Ya-Nan Wang et al.   ChemMedChem

Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation

(2018) Han-Bo Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile

(2018) Lok-Hang Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii

(2018) Wei-Wei Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi

(2018) Yuan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antifungal activity and mechanism of monocaprin against food spoilage fungi

(2018) Maomao Ma et al.   FOOD CONTROL

Worldwide emergence of resistance to antifungal drugs challenges human health and food security

(2018) Matthew C. Fisher et al.   SCIENCE

Potential Antimicrobial Isopropanol-Conjugated Carbazole Azoles as Dual Targeting Inhibitors of Enterococcus faecalis

(2018) Yuan Zhang et al.   ACS Medicinal Chemistry Letters

Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant Staphylococcus aureus

(2018) Di Li et al.   MedChemComm

Design, synthesis and evaluation of 4-aminoquinoline-purine hybrids as potential antiplasmodial agents

(2017) P. Linga Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N6-Substituted 5′-N-Methylcarbamoyl-4′-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation

(2017) Jinha Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents

(2017) Wei-Wei Gao et al.   Science China-Chemistry

Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli

(2017) Guo-Biao Zhang et al.   Science China-Chemistry

Design, synthesis and biological evaluation of novel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents

(2017) Jun-Rong Duan et al.   MedChemComm

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents

(2017) Ying-Ying Chen et al.   ACS Medicinal Chemistry Letters

High Antibacterial Activity of Functionalized Chemically Exfoliated MoS2

(2016) Subhendu Pandit et al.   ACS Applied Materials & Interfaces

Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents

(2016) Xue-Jie Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cell Proliferation and Cytotoxicity Assays

(2016) Aysun Adan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents

(2016) Ling Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism

(2016) Sheng-Feng Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioactive thiazole and benzothiazole derivatives

(2015) Abdul Rouf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial behavior of biosynthesized silica–silver nanocomposite for water disinfection: A mechanistic perspective

(2015) Thanusu Parandhaman et al.   JOURNAL OF HAZARDOUS MATERIALS

Fungus against the wall

(2015) Paul O'Maille   NATURE

Lactate Dehydrogenase Is the Key Enzyme for Pneumococcal Pyruvate Metabolism and Pneumococcal Survival in Blood

(2014) Paula Gaspar et al.   INFECTION AND IMMUNITY

Membrane Active Phenylalanine Conjugated Lipophilic Norspermidine Derivatives with Selective Antibacterial Activity

(2014) Mohini M. Konai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Carboline Derivatives as Potent Antifungal Lead Compounds: Design, Synthesis, and Biological Evaluation

(2014) Shengzheng Wang et al.   ACS Medicinal Chemistry Letters

Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

(2013) Ling Zhang et al.   MEDICINAL RESEARCH REVIEWS

Apoptosis-inducing antifungal peptides and proteins: Table 1

(2012) Katrijn De Brucker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Pseudomonas aeruginosa membranes: A target for a new amphiphilic aminoglycoside derivative?

(2011) Myriam Ouberai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents

(2010) Yuan Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS