The antibacterial activity of fluoroquinolone derivatives: An update (2018–2021)

Antibiotic resistance and drug modification: Synthesis, characterization and bioactivity of newly modified potent ciprofloxacin derivatives

(2021) Abdulhakeem Alsughayer et al.   BIOORGANIC CHEMISTRY

Synthesis, antitumor, antibacterial and urease inhibitory evaluation of new piperazinyl N-4 carbamoyl functionalized ciprofloxacin derivatives

(2021) Mohamed A. A. Abdel-Aal et al.   Pharmacological Reports

In Vitro and In Vivo Antibacterial Activities of a Novel Quinolone Compound, OPS-2071, Against Clostridioides difficile

(2021) Daisuke Oka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Mannich bases of ciprofloxacin with improved physicochemical properties, antibacterial, anticancer activities and caspase-3 mediated apoptosis

(2021) Islam M. Abdel-Rahman et al.   BIOORGANIC CHEMISTRY

Recent Innovations in Bacterial Infection Detection and Treatment

(2021) Carly Deusenbery et al.   ACS Infectious Diseases

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors

(2021) Lamya H. Al-Wahaibi et al.   Pharmaceuticals

Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments

(2020) Prinessa Chellan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides

(2020) Bing-Zhi Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluoroquinolone Metalloantibiotics: A Promising Approach against Methicillin-Resistant Staphylococcus aureus

(2020) Mariana Ferreira et al.   International Journal of Environmental Research and Public Health

Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity

(2020) Natalia Ptaszyńska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of Bioactive Complex Small Molecule–Ciprofloxacin Conjugates and Evaluation of Their Antibacterial Activity

(2020) Rahul Upadhyay et al.   ACS Combinatorial Science

Synthesis, characterization, antimicrobial activity, 3D‐QSAR, DFT, and molecular docking of some ciprofloxacin derivatives and their copper(II) complexes

(2020) Tarek E. Khalil et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Synthesis and antimicrobial evaluation of new nitric oxide‐donating fluoroquinolone/oxime hybrids

(2020) Hossameldin A. Aziz et al.   ARCHIV DER PHARMAZIE

Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections

(2020) Ralph Kirk et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives

(2020) Aya A.M. Mohammed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multidrug-Resistant Bacteria in the Community

(2020) David van Duin et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Spectral, structural, biological and molecular docking studies of a new mixed-valence V(IV)/V(V) ofloxacin complex

(2020) Mina Alikhani et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel N-4-Piperazinyl Ciprofloxacin-Ester Hybrids: Synthesis, Biological Evaluation, and Molecular Docking Studies

(2020) A. Shahbazi et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Design, synthesis, molecular docking study, and antibacterial evaluation of some new fluoroquinolone analogues bearing a quinazolinone moiety

(2020) Maryam Norouzbahari et al.   DARU-Journal of Pharmaceutical Sciences

Design, Synthesis and Pharmacological Evaluation of Some C3 Heterocyclic-Substituted Ciprofloxacin Derivatives as Chimeric Antitubercular Agents

(2020) Nakka Niveditha et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Roles of long noncoding RNAs in bacterial infection

(2020) Yating Wen et al.   LIFE SCIENCES

Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones

(2019) Satoshi Komoriya et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Biological investigations and spectroscopic studies of new Moxifloxacin/Glycine-Metal complexes

(2019) Hazem Salaheldin Elshafie et al.   CHEMISTRY & BIODIVERSITY

DESIGN, SYNTHESIS, MOLECULAR DOCKING, AND ANTIBACTERIAL ACTIVITY EVALUATION OF SOME NOVEL NORFLOXACIN ANALOGUES

(2019) SMARANDA ONIGA   FARMACIA

Synthesis, characterization and biological evaluation of Co(III) complexes with quinolone drugs

(2019) Máté Kozsup et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, characterization and biological activity of Zn coordination compounds with the quinolone gatifloxacin

(2019) Chrisoula Kakoulidou et al.   POLYHEDRON

Design, synthesis and anti-bacterial studies of piperazine derivatives against drug resistant bacteria

(2019) Saba Tahir et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New fluoroquinolones compounds with endo -nortropine derivatives at C-7 position show antibacterial activity against fluoroquinolone-resistant strains of Staphylococcus aureus

(2019) Ramkrushna Ashok Salunke et al.   Chemical Biology & Drug Design

Metal Complexes As Promising Agents For Biomedical Applications

(2019) Natalia V. Loginova et al.   CURRENT MEDICINAL CHEMISTRY

Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polymeric bisphosphonate derivative of ciprofloxacin – synthesis, structural analysis and antibacterial activity of the prospective conjugate

(2019) Marcin Sobczak et al.   International Journal of Polymeric Materials and Polymeric Biomaterials

Fluoroquinolones structural and medicinal developments (2013–2018): Where are we now?

(2019) Ghadeer A.R.Y. Suaifan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity

(2019) Hamada H.H. Mohammed et al.   BIOORGANIC CHEMISTRY

Design, synthesis and molecular modeling studies on novel moxifloxacin derivatives as potential antibacterial and antituberculosis agents

(2019) Aslı Türe et al.   BIOORGANIC CHEMISTRY

Repurposed Antimicrobial Combination Therapy: Tobramycin-Ciprofloxacin Hybrid Augments Activity of the Anticancer Drug Mitomycin C Against Multidrug-Resistant Gram-Negative Bacteria

(2019) Ronald Domalaon et al.   Frontiers in Microbiology

Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

(2019) Yong Guo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives

(2019) Hamada H. H. Mohammed et al.   MONATSHEFTE FUR CHEMIE

Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids

(2019) Feng Gao et al.   BIOORGANIC CHEMISTRY

Novel 7-substituted Fluoroquinolone Citrate Conjugates as Powerful Antibacterial and Anticancer Agents: Synthesis and Molecular Docking Studies

(2019) Tejeswara R. Allaka et al.   CURRENT ORGANIC CHEMISTRY

A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents

(2019) Joanna Fedorowicz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents

(2019) Marc et al.   MOLECULES

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity

(2019) Benedetta Fois et al.   ChemMedChem

Anticancer and antimicrobial effects of novel ciprofloxacin fatty acids conjugates

(2019) Alicja Chrzanowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Theoretical molecular predictions and antimicrobial activities of newly synthesized molecular hybrids of norfloxacin and ciprofloxacin

(2019) Gurmeet Kaur et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

A new calcium(II) complex of marbofloxacin showing much lower acute toxicity with retained antibacterial activity

(2019) Yan-Jie Xie et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Crystal structure and antibacterial activity of polyoxometalate cobalt-ciprofloxacin complex

(2019) Guang-Zhi Shen et al.   JOURNAL OF MOLECULAR STRUCTURE

Introduction of the antibacterial drugs norfloxacin and Ciprofloxacin into a polyoxometalate structure: Synthesis, characterization, and antibacterial activity

(2019) Yu-Long Zou et al.   JOURNAL OF MOLECULAR STRUCTURE

New triorganotin(IV) complexes of quinolone antibacterial drug sparfloxacin: Synthesis, structural characterization, DFT studies and biological activity

(2018) Rachana Joshi et al.   APPLIED ORGANOMETALLIC CHEMISTRY

In silico study of Moxifloxacin derivatives with possible antibacterial activity against a resistant form of DNA gyrase from Porphyromonas gingivalis

(2018) Cristian Rocha-Roa et al.   ARCHIVES OF ORAL BIOLOGY

Discovery of a Novel Fluoroquinolone Antibiotic Candidate WFQ-228 with Potent Antimicrobial Activity and the Potential to Overcome Major Drug Resistance

(2018) Tatsuya Hirano et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Design, Synthesis and Antibacterial Evaluation of 1-[(1R, 2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H )-thione Hybrids

(2018) Yang Gao et al.   CHEMISTRY & BIODIVERSITY

Biology-Oriented Drug Synthesis (BIODS) Approach towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential both in vitro and in silico

(2018) Ensieh Nasli Esfahani et al.   CHEMISTRY & BIODIVERSITY

Discovery of Benzimidazole-Quinolone Hybrids as New Cleaving Agents toward Drug-Resistant Pseudomonas aeruginosa DNA

(2018) Ya-Nan Wang et al.   ChemMedChem

Ciprofloxacin-metal complexes –stability and toxicity tests in the presence of humic substances

(2018) Agnieszka Cuprys et al.   CHEMOSPHERE

Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity

(2018) Asmaa E. Kassab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids

(2018) Ruo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates

(2018) Hassan M. Faidallah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel 8-Methoxyquinolones Bearing Fused Pyrrolidinyl Moieties at the C-7 Position with Potent Antibacterial Activity Against Respiratory Pathogens

(2018) Takashi Odagiri et al.   HETEROCYCLES

Design, Synthesis, and In Vitro Antibacterial Activities of Propylene-tethered Gatifloxacin-isatin Hybrids

(2018) Hua Guo   JOURNAL OF HETEROCYCLIC CHEMISTRY

4-Quinolone Derivatives and Their Activities Against Gram-negative Pathogens

(2018) Dan Jiang   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis, spectroscopic, thermal, biological, morphological and molecular docking studies of the different quinolone drugs and their cobalt(II) complexes

(2018) Foziah A. Al-Saif et al.   JOURNAL OF MOLECULAR LIQUIDS

Combined experimental and theoretical studies on the diorganotin(IV) complexes of sparfloxacin: Synthesis, spectroscopic and DFT studies, and biological activity

(2018) Rachana Joshi et al.   JOURNAL OF MOLECULAR STRUCTURE

Chemical and biological evaluation of moxifloxacin-benzimidazole mixed ligands complexes: Anti-cancer and anti-oxidant activities

(2018) Heba M. Refaat et al.   JOURNAL OF MOLECULAR STRUCTURE

Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin–Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity

(2018) Wilma Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced Antibacterial Activity of Endo-nortropine Substituted (C-7) Fluoroquinolones Against V. cholerae, S. aureus and B. subtilis

(2018) Ramkrushna Ashok Salunke et al.   Letters in Drug Design & Discovery

Synthesis, Spectroscopic, and Biological Studies of Mixed Ligand Complexes of Gemifloxacin and Glycine with Zn(II), Sn(II), and Ce(III)

(2018) Shimaa Sakr et al.   MOLECULES

The role of vaccines in preventing bacterial antimicrobial resistance

(2018) Kathrin U Jansen et al.   NATURE MEDICINE

Recent updates of fluoroquinolones as antibacterial agents

(2018) Hend A. A. Ezelarab et al.   ARCHIV DER PHARMAZIE

Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA)

(2018) Chuan Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent developments of quinolone-based derivatives and their activities against Escherichia coli

(2018) Feng Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Interaction of triorganotin(IV) moiety with quinolone antibacterial drug ciprofloxacin: Synthesis, spectroscopic investigation, electronic structure calculation, and biological evaluation

(2018) Rachana Joshi et al.   HETEROATOM CHEMISTRY

Design, Synthesis, and Antibacterial Evaluation of Propylene-tethered 8-Methoxyl Ciprofloxacin-isatin Hybrids

(2018) Hua Guo   JOURNAL OF HETEROCYCLIC CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel 7-[(3aS,7aS)-3a-Aminohexahydropyrano[3,4-c]pyrrol-2(3H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens

(2018) Takashi Odagiri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antibacterial/Antitubercular/Antioxidant Activities of Compounds Containing Fluoroquinolone Ring Linked to a 4-thiazolidinone Moiety

(2018) Tejeswara Rao Allaka et al.   Letters in Drug Design & Discovery

New model of metalloantibiotic: synthesis, structure and biological activity of a zinc(ii) mononuclear complex carrying two enrofloxacin and sulfadiazine antibiotics

(2018) Amina Boughougal et al.   NEW JOURNAL OF CHEMISTRY

Synthesis, Antimicrobial Activity and QSAR Studies of Some New Sparfloxacin Derivatives

(2018) Ayush Kumar et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

New ciprofloxacin–dithiocarbamate–benzyl hybrids: design, synthesis, antibacterial evaluation, and molecular modeling studies

(2018) Ensieh Nasli Esfahani et al.   RESEARCH ON CHEMICAL INTERMEDIATES

New N -4 piperazinyl derivatives of norfloxacin: design, synthesis, and correlation of calculated physicochemical parameters with antibacterial activity

(2018) Gamal El-Din ABUO-RAHMA et al.   TURKISH JOURNAL OF CHEMISTRY

Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids

(2018) Serpil Demirci et al.   HETEROCYCLIC COMMUNICATIONS

N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluation

(2018) Ali Asadipour et al.   DARU-Journal of Pharmaceutical Sciences

In vitro activities of a new fluoroquinolone derivative highly active against Chlamydia trachomatis

(2018) Thi Huyen Vu et al.   BIOORGANIC CHEMISTRY

4-Quinolone hybrids and their antibacterial activities

(2017) Yuan-Qiang Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel tetrazole containing hybrid ciprofloxacin and pipemidic acid analogues and preliminary biological evaluation of their antibacterial and antiproliferative activity

(2017) Kommula Dileep et al.   MOLECULAR DIVERSITY

Photodynamic antimicrobial chemotherapy with cationic phthalocyanines against Escherichia coli planktonic and biofilm cultures

(2017) Min Li et al.   RSC Advances