Recent updates of fluoroquinolones as antibacterial agents

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

(2018) Ronald Domalaon et al.   CLINICAL MICROBIOLOGY REVIEWS

Bacteria That Make a Meal of Sulfonamide Antibiotics: Blind Spots and Emerging Opportunities

(2018) Yu Deng et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

In vitro activity of Nigella sativa against antibiotic resistant Salmonella enterica

(2018) Sadia Ashraf et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ciprofloxacin derivatives and their antibacterial activities

(2018) Gui-Fu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4-Quinolone derivatives and their activities against Gram positive pathogens

(2018) Gui-Fu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluoroquinolone derivatives and their anti-tubercular activities

(2018) Yi-Lei Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii

(2018) Wei-Wei Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates

(2018) Hassan M. Faidallah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene (acrR) on phenicol resistance

(2018) Muhammad Yaqoob et al.   FOLIA MICROBIOLOGICA

Decrease of the affinity of theophylline bind to serum proteins induced by flavonoids and their synergies on protein conformation

(2018) Xin Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Copper-Catalyzed Aza-Michael Addition of 2-Aminobenzoate to β-Substituted α,β-Unsaturated Ketones: One-Pot Synthesis of 3-Carbonyl-2-Substituted Quinolin-4(1H)-ones

(2018) Seongil Kang et al.   JOURNAL OF ORGANIC CHEMISTRY

Periprosthetic bacterial biofilm and quorum sensing

(2018) Jake A. Mooney et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Eco-friendly synthesis, in vitro anti-proliferative evaluation, and 3D-QSAR analysis of a novel series of monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates

(2018) Livio Racané et al.   MOLECULAR DIVERSITY

Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives

(2018) Priscila López-Rojas et al.   MOLECULES

Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria

(2018) Annamária Kincses et al.   PHYTOTHERAPY RESEARCH

Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken

(2018) Zohaib Ahmed Bhutto et al.   Scientific Reports

Synthesis, quantitative structure–property relationship study of novel fluorescence active 2-pyrazolines and application

(2018) Adel S. Girgis et al.   Royal Society Open Science

Design, Microwave-Assisted and Conventional Synthesis of New Hybrid Compounds Derived From 1-(4-Fluorophenyl)piperazine and Screening for Their Biological Activities

(2018) Serap Basoglu Ozdemir et al.   ChemistrySelect

Recent advances in design of new urease inhibitors: A review

(2018) Paweł Kafarski et al.   Journal of Advanced Research

Removal of fluoroquinolone from aqueous solution using graphene oxide: experimental and computational elucidation

(2017) Sarita Yadav et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

4-Quinolone hybrids and their antibacterial activities

(2017) Yuan-Qiang Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity

(2017) Dražen Pavlović et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

(2017) Serap Basoglu Ozdemir et al.   HETEROCYCLIC COMMUNICATIONS

Synthesis of Some New Ciprofloxacin Hybrids as Potential Antimicrobial Agents

(2017) Meltem Menteşe et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Bifunctional antimicrobial conjugates and hybrid antimicrobials

(2017) P. Klahn et al.   NATURAL PRODUCT REPORTS

Synthesis and molecular modeling of antimicrobial active fluoroquinolone–pyrazine conjugates with amino acid linkers

(2016) Siva S. Panda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones

(2016) Elena Chugunova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton

(2016) Sule Ceylan et al.   HETEROCYCLIC COMMUNICATIONS

Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux

(2016) Bala Kishan Gorityala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections

(2016) Zhenkun Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal-based biologically active compounds: design, synthesis, medicinal, toxicity and DNA interaction assay

(2016) Sanjaykumar B. Gajera et al.   MEDICINAL CHEMISTRY RESEARCH

Nonclassical Biological Activities of Quinolone Derivatives

(2016) Mohsen Daneshtalab et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy

(2015) Bala Kishan Gorityala et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1,8-Naphthyridine Derivatives: A Review of Multiple Biological Activities

(2015) Alka Madaan et al.   ARCHIV DER PHARMAZIE

Novel antibacterial active quinolone–fluoroquinolone conjugates and 2D-QSAR studies

(2015) Siva S. Panda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space

(2015) Audrey G. Ross et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu2+ mediated DNA-targeting antibacterial agents

(2015) Ling Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tobramycin and Nebramine as Pseudo-oligosaccharide Scaffolds for the Development of Antimicrobial Cationic Amphiphiles

(2015) Yifat Berkov-Zrihen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Analysis of effects of MCB3681, the antibacterially active substance of prodrug MCB3837, on human resident microflora as proof of principle

(2015) A. Dalhoff et al.   CLINICAL MICROBIOLOGY AND INFECTION

Discovery of WQ-3810: Design, synthesis, and evaluation of 7-(3-alkylaminoazetidin-1-yl)fluoro-quinolones as orally active antibacterial agents

(2015) Kenji Itoh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antimycobacterial and antibacterial activity of fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety

(2015) Tingting Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Evaluation of Antibacterial Effects of a New Class of Piperazinylquinolone Derivatives

(2015) Ali Darehkordi et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids

(2015) Tomasz Plech et al.   MOLECULES

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

(2014) Xu-Dong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quinolone–benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer Disease

(2014) Marc Pudlo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antibiotic Adjuvants: Diverse Strategies for Controlling Drug-Resistant Pathogens

(2014) Erin E. Gill et al.   Chemical Biology & Drug Design

Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety

(2014) Hongmin Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

(2014) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds

(2013) Kai Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA

(2013) Sheng-Feng Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: Synthesis, in vitro antibacterial activity and in silico study

(2013) Saeed Emami et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity

(2013) Mohamed Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural requirements of 3-carboxyl-4(1H)-quinolones as potential antimalarials from 2D and 3D QSAR analysis

(2013) Jiazhong Li et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

7-Piperazinylquinolones with methylene-bridged nitrofuran scaffold as new antibacterial agents

(2013) Saeed Emami et al.   MEDICINAL CHEMISTRY RESEARCH

DNA interactions and promotion in antibacterial activities of the norfloxacin drug due to formation of mixed-ligand copper(II) complexes

(2013) Mohan N. Patel et al.   MONATSHEFTE FUR CHEMIE

6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes

(2012) Ido M. Herzog et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety

(2012) Qing-Rong Qi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents

(2012) Yan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and in vitro Antibacterial Activity of Fluoroquinolone Derivatives Containing a Chiral 3-(Alkoxyimino)-2-(aminomethyl)azetidine Moiety

(2012) Kai Lv et al.   ChemMedChem

Synthesis, characterization and biological studies of mononuclear copper(II) complexes with ciprofloxacin and N, O donor ligands

(2012) Mohan N. Patel et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Biochemistry of Bacterial Multidrug Efflux Pumps

(2012) Sanath Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytotoxic, antibacterial, DNA interaction and superoxide dismutase like activities of sparfloxacin drug based copper(II) complexes with nitrogen donor ligands

(2012) Mohan N. Patel et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis and in vitro antibacterial activity of 7-(3-Alkoxyimino-4-amino-4-methylpiperidin-1-yl) fluoroquinolone derivatives

(2011) Ju-Xian Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DNA interaction and in-vitro antibacterial studies of fluoroquinolone based platinum(II) complexes

(2011) Mohan N. Patel et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions

(2011) Van Tran et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials

(2010) Dražen Pavlović et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-5-amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives

(2010) Yibin Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

(2010) Varvara Pokrovskaya et al.   Expert Opinion on Drug Discovery

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

(2010) Prabodh Chander Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

ABC proteins in antigen translocation and viral inhibition

(2010) David Parcej et al.   Nature Chemical Biology

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents

(2009) Xiaoguang Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics

(2009) Varvara Pokrovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Factor analysis of microbiological activity data and structural parameters of antibacterial quinolones

(2009) Marcin Koba et al.   JOURNAL OF MOLECULAR MODELING

Review of third-and fourth-generation fluoroquinolones in ophthalmology: in-vitro and in-vivo efficacy

(2008) Stephen V. Scoper   ADVANCES IN THERAPY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

How many modes of action should an antibiotic have?

(2008) H BROTZOESTERHELT et al.   CURRENT OPINION IN PHARMACOLOGY