An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a

N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones of 6-alkoxy-2-oxo-2H-chromene-4-carbaldehydes: synthesis, evaluation of their antibacterial, anti-MRSA, antifungal activity, and docking study

(2021) Vu Ngoc Toan et al.   MEDICINAL CHEMISTRY RESEARCH

Unconventional Antibacterials and Adjuvants

(2021) Mayland Chang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Natural Isoflavones and Semisynthetic Derivatives as Pancreatic Lipase Inhibitors

(2021) Nunzio Cardullo et al.   JOURNAL OF NATURAL PRODUCTS

Pyrimidinetrione‐imidazoles as a Unique Structural Type of Potential Agents towards Candida Albicans : Design, Synthesis and Biological Evaluation

(2021) Yan‐Fei Sui et al.   Chemistry-An Asian Journal

Design and Synthesis of Sulfanilamide Aminophosphonates as Novel Antibacterial Agents towards Escherichia Coli

(2021) Juan Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity

(2021) Jin-Ping Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors

(2021) Jie Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular design and preparation of 2-aminothiazole sulfanilamide oximes as membrane active antibacterial agents for drug resistant Acinetobacter baumannii

(2021) Juan Wang et al.   BIOORGANIC CHEMISTRY

Natural Berberine-Hybridized Benzimidazoles as Novel Unique Bactericides against Staphylococcus aureus

(2021) Hang Sun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Novel carbazole-oxadiazoles as potential Staphylococcus aureus germicides

(2021) Yun-Peng Xie et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Synthesis of naphthalimide triazoles with a novel structuralframework and their anti-<italic>Aspergillus</italic><italic> fumigatus</italic> effects

(2021) Peng-Li Zhang et al.   Scientia Sinica Chimica

Nucleus-targeting imaging and enhanced cytotoxicity based on naphthalimide derivatives

(2021) Shan-Shan Wang et al.   BIOORGANIC CHEMISTRY

A naphthalimide-polyamine conjugate preferentially accumulates in hepatic carcinoma metastases as a lysosome-targeted antimetastatic agent

(2021) Jing Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms

(2021) Yan-Fei Sui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of a novel antifungal backbone of naphthalimide thiazoles with synergistic potential for chemical and dynamic treatment

(2021) Peng-Li Zhang et al.   Future Medicinal Chemistry

Development of Asialoglycoprotein-Mediated Hepatocyte-Targeting Antitumor Prodrugs Triggered by Glutathione

(2021) Mian Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A retrospect on antimicrobial potential of thiazole scaffold

(2020) Isha Mishra et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials

(2020) Yuanyuan Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Penicillin binding protein 2a: An overview and a medicinal chemistry perspective

(2020) Menna-Allah W. Shalaby et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA

(2020) Gui-Bin Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators

(2020) Yuan-Yuan Hu et al.   Future Medicinal Chemistry

Flavonoids as Potential anti-MRSA Agents through Modulation of PBP2a: A Computational and Experimental Study

(2020) Hani A. Alhadrami et al.   Antibiotics-Basel

Synthesis and Biological Evaluation of Quinazolonethiazoles as New Potential Conquerors towards Pseudomonas Aeruginosa

(2020) Jie Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

(2020) Rameshwari Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sulfonamide-derived Four-component Molecular Hybrids as Novel DNA-targeting Membrane Active Potentiators against Clinical Escherichia coli

(2019) Yuan-Yuan Hu et al.   MOLECULAR PHARMACEUTICS

Development of Fungal Selective Amphiphilic Kanamycin: Cost-Effective Synthesis and Use of Fluorescent Analogs for Mode of Action Investigation

(2019) Yagya Prasad Subedi et al.   ACS Infectious Diseases

The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant Staphylococcus aureus

(2019) Jeshina Janardhanan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene−d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities

(2019) Nguyen Dinh Thanh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Formation of two centre three electron bond by hydroxyl radical induced reaction of thiocoumarin: evidence from experimental and theoretical studies

(2019) Rupali G. Shinde et al.   FREE RADICAL RESEARCH

Post-stress bacterial cell death mediated by reactive oxygen species

(2019) Yuzhi Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus

(2019) Enrico Speri et al.   ACS Medicinal Chemistry Letters

Variedly connected 1,8-naphthalimide-7-chloroquinoline conjugates: Synthesis, anti-mycobacterial and cytotoxic evaluation

(2019) Shalini et al.   BIOORGANIC CHEMISTRY

Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus

(2019) Chun-Fang Hu et al.   BIOORGANIC CHEMISTRY

A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV

(2019) Liang-Liang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus

(2019) Zhen-Zhen Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potential anticancer agent for selective damage to mitochondria or lysosomes: Naphthalimide-modified fluorescent biomarker half-sandwich iridium (III) and ruthenium (II) complexes

(2019) Wenli Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove

(2018) Ya-Nan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii

(2018) Wei-Wei Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel naphthalimide nitroimidazoles as multitargeting antibacterial agents against resistant Acinetobacter baumannii

(2018) Jie Kang et al.   Future Medicinal Chemistry

Design and synthesis of a new series of low toxic naphthalimide platinum(IV) antitumor complexes with dual DNA damage mechanism

(2018) Qingpeng Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues

(2017) Hui-Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tackling Fungal Resistance by Biofilm Inhibitors

(2017) Shanchao Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections

(2017) Veerasak Srisuknimit et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli

(2017) Guo-Biao Zhang et al.   Science China-Chemistry

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents

(2017) Ying-Ying Chen et al.   ACS Medicinal Chemistry Letters

A Natural Lipotrisaccharide and Its Derivatives Selectively Lyse Streptococcus pneumoniae via Interaction with Cell Membrane

(2017) Bo Liu et al.   ACS Infectious Diseases

Lactate Dehydrogenase Inhibition: Biochemical Relevance and Therapeutical Potential

(2017) Giuseppina Laganá et al.   CURRENT MEDICINAL CHEMISTRY

In VitroandIn VivoSynergy of the Oxadiazole Class of Antibacterials with β-Lactams

(2016) Jeshina Janardhanan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

(2016) Yu Cheng et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Heterocyclic Naphthalimides as New Skeleton Structure of Compounds with Increasingly Expanding Relational Medicinal Applications

(2016) Huo-Hui Gong et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N- (2,3,4,6-tetra- O -acetyl-β -d- glucopyranosyl)thiosemicarbazones

(2016) Nguyen Dinh Thanh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents

(2016) Ling Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells

(2016) Yu Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

(2016) Renee Bouley et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Progress in Azole Compounds as Antimicrobial Agents

(2016) Hui-Zhen Zhang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Bioactive thiazole and benzothiazole derivatives

(2015) Abdul Rouf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A polyphenolic flavonoid glabridin: Oxidative stress response in multidrug-resistant Staphylococcus aureus

(2015) Vigyasa Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

(2015) Renee Bouley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel benzimidazole derived naphthalimide triazoles: synthesis, antimicrobial activity and interactions with calf thymus DNA

(2015) Yun-Lei Luo et al.   Science China-Chemistry

Membrane Active Phenylalanine Conjugated Lipophilic Norspermidine Derivatives with Selective Antibacterial Activity

(2014) Mohini M. Konai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

(2014) Jennifer Fishovitz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rationally Designed Multitarget Anticancer Agents

(2013) Zhuo Chen et al.   CURRENT MEDICINAL CHEMISTRY

Macrocycle-embedded β-lactams as novel inhibitors of the Penicillin Binding Protein PBP2a from MRSA

(2013) Georges Dive et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

(2013) Ling Zhang et al.   MEDICINAL RESEARCH REVIEWS

A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents

(2013) Guri L. V. Damu et al.   Science China-Chemistry

Synthetic amphiphiles as therapeutic antibacterials: lessons on bactericidal efficacy and cytotoxicity and potential application as an adjuvant in antimicrobial chemotherapy

(2013) Sudeep Goswami et al.   Journal of Materials Chemistry B

Recent Researches in Triazole Compounds as Medicinal Drugs

(2012) C. -H. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents

(2011) Yi-Yi Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Spectroscopic Studies of Farrerol Interaction with Calf Thymus DNA

(2011) Guowen Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY