Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment

Real-Time Quantification of Cartilage Degeneration by GAG-Targeted Cationic Nanoparticles for Efficient Therapeutic Monitoring in Living Mice

(2021) Shuyi Xiao et al.   MOLECULAR PHARMACEUTICS

Sodium Monoiodoacetate Dose-Dependent Changes in Matrix Metalloproteinases and Inflammatory Components as Prognostic Factors for the Progression of Osteoarthritis

(2021) Marta Bryk et al.   Frontiers in Pharmacology

Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis

(2021) Jingwen Luo et al.   CARBOHYDRATE POLYMERS

Novel rhein integrate transphytosomes as non-invasive local therapy for osteoarthritis to ameliorate cartilage deterioration in MIA-arthritic rats

(2021) Heba M.K. Ebada et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Diacerein-Loaded Hyaluosomes as a Dual-Function Platform for Osteoarthritis Management via Intra-Articular Injection: In Vitro Characterization and In Vivo Assessment in a Rat Model

(2021) Nouran O. Eladawy et al.   Pharmaceutics

Glucosamine and Chondroitin Sulfate: Is There Any Scientific Evidence for Their Effectiveness as Disease-Modifying Drugs in Knee Osteoarthritis Preclinical Studies?—A Systematic Review from 2000 to 2021

(2021) Silvia Fernández-Martín et al.   Animals

Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

(2021) Sean K. Bedingfield et al.   Nature Biomedical Engineering

The Influence of Relative Humidity and Storage Conditions on the Physico-chemical Properties of Inhalation Grade Fine Lactose

(2021) Milica Stankovic-Brandl et al.   AAPS PHARMSCITECH

Bile acid transporter-mediated oral absorption of insulin via hydrophobic ion-pairing approach

(2021) Santosh Bashyal et al.   JOURNAL OF CONTROLLED RELEASE

Joint distraction for osteoarthritis: clinical evidence and molecular mechanisms

(2021) Mylène P. Jansen et al.   Nature Reviews Rheumatology

Solid lipid nanoparticles: a review on recent perspectives and patents

(2020) Rishi Paliwal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis

(2020) Jae Hyun Jung et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery

(2020) Ruba Ismail et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The perspectives of intra-articular therapy in the management of osteoarthritis

(2020) Alberto Migliore et al.   Expert Opinion on Drug Delivery

Hydrophobic ion pair loaded self-emulsifying drug delivery system (SEDDS): A novel oral drug delivery approach of cromolyn sodium for management of bronchial asthma

(2020) Marwa Hasanein Asfour et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Biomaterial strategies for improved intra‐articular drug delivery

(2020) Lina María Mancipe Castro et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Internal liquid crystal structures in nanocarriers containing drug hydrophobic ion pairs dictate drug release

(2020) Kurt Ristroph et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Self-emulsifying drug delivery systems containing hydrophobic ion pairs of polymyxin B and agaric acid: A decisive strategy for enhanced antimicrobial activity

(2020) Aamir Jalil et al.   JOURNAL OF MOLECULAR LIQUIDS

Ion Pair Strategy in Solid Lipid Nanoparticles: a Targeted Approach to Improve Epidermal Targeting with Controlled Adapalene Release, Resulting Reduced Skin Irritation

(2020) Linna B. O. Rodrigues et al.   PHARMACEUTICAL RESEARCH

Nanotechnology application in drug delivery to osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OSP)

(2020) Morteza Rabiei et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics

(2020) Taylor B. Lawson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Self-Emulsifying Drug Delivery Systems: Hydrophobic Drug Polymer Complexes Provide a Sustained Release in Vitro

(2020) Ahmad Malkawi et al.   MOLECULAR PHARMACEUTICS

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

(2020) Bo Hu et al.   AMB Express

Novel rhein–phospholipid complex targeting skin diseases: development, in vitro, ex vivo, and in vivo studies

(2020) Heba M. K. Ebada et al.   Drug Delivery and Translational Research

The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration

(2020) Zhi Peng et al.   BIOMATERIALS

Non-surgical Osteoarthritis Therapy, Intra-Articular Drug Delivery Toward Clinical Applications

(2020) Yujie Liang et al.   JOURNAL OF DRUG TARGETING

Intra-articular targeting of nanomaterials for the treatment of osteoarthritis

(2019) Shannon Brown et al.   Acta Biomaterialia

Effects of cartilage-targeting moieties on nanoparticle biodistribution in healthy and osteoarthritic joints

(2019) Shannon B. Brown et al.   Acta Biomaterialia

Optimization of rhein-loaded polymeric nanoparticles using a factorial design and evaluation of the cytotoxic and anti-inflammatory effects

(2018) Carolina Gómez-Gaete et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Recent advances in intra-articular drug delivery systems for osteoarthritis therapy

(2018) Pierre Maudens et al.   DRUG DISCOVERY TODAY

Inducible nitric oxide synthase as a target for osteoarthritis treatment

(2018) Andreas Leonidou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis

(2017) Carolina Gómez-Gaete et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Chitosan-coated diacerein nanosuspensions as a platform for enhancing bioavailability and lowering side effects: preparation, characterization, and ex vivo/in vivo evaluation

(2017) Ahmed Allam et al.   International Journal of Nanomedicine

Supramolecular nano-engineered lipidic carriers based on diflunisal-phospholipid complex for transdermal delivery: QbD based optimization, characterization and preclinical investigations for management of rheumatoid arthritis

(2017) Amanpreet Kaur et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A novel chondroitin sulfate decorated nano platinum for the treatment of osteoarthritis

(2017) Xue-feng Yin et al.   Materials Science & Engineering C-Materials for Biological Applications

Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice

(2016) Julie Pradal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Celecoxib-loaded PEA microspheres as an auto regulatory drug-delivery system after intra-articular injection

(2016) Maarten Janssen et al.   JOURNAL OF CONTROLLED RELEASE

Preclinical evaluation of 99mTc labeled chondroitin sulfate for monitoring of cartilage degeneration in osteoarthritis

(2016) Grazyna Sobal et al.   NUCLEAR MEDICINE AND BIOLOGY

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

Preparation, characterization, and in vivo study of rhein-loaded poly(lactic-co-glycolic acid) nanoparticles for oral delivery

(2015) Xinhua Gu et al.   Drug Design Development and Therapy

Solubility and solution thermodynamics of rhein in eight pure solvents from (288.15 to 313.15) K

(2015) Yan Cheng et al.   RSC Advances

Polyethylene-Glycol-Modified Single-Walled Carbon Nanotubes for Intra-Articular Delivery to Chondrocytes

(2014) Cristiano Sacchetti et al.   ACS Nano

Histology, Glycosaminoglycan Level and Cartilage Stiffness in Monoiodoacetate-Induced Osteoarthritis: Comparative Analysis with Anterior Cruciate Ligament Transection in Rat Model and Human Osteoarthritis

(2014) Sangeetha Vasudevaraj Naveen et al.   International Journal of Medical Sciences

Aceclofenac-loaded chondroitin sulfate conjugated SLNs for effective management of osteoarthritis

(2014) Mamta Bishnoi et al.   JOURNAL OF DRUG TARGETING

Targeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in rats

(2014) Achint Jain et al.   Nanomedicine-Nanotechnology Biology and Medicine

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

(2013) Mei Li et al.   ACTA PHARMACOLOGICA SINICA

Development of Lipid Nanoparticles of Diacerein, an Antiosteoarthritic Drug for Enhancement in Bioavailability and Reduction in its Side Effects

(2013) Achint Jain et al.   Journal of Biomedical Nanotechnology

Uptake studies with chondrotropic 99mTc-chondroitin sulfate in articular cartilage. Implications for imaging osteoarthritis in the knee

(2013) Grazyna Sobal et al.   NUCLEAR MEDICINE AND BIOLOGY

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat

(2010) N. Gerwin et al.   OSTEOARTHRITIS AND CARTILAGE

Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles

(2009) Gisele A. Castro et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Solubility, spectroscopic properties and photostability of Rhein/cyclodextrin inclusion complex

(2009) Stefania Petralito et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long-term culture

(2008) Liming Bian et al.   JOURNAL OF BIOMECHANICS

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

(2008) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY

Radiolabeling procedure, quality control and stability of 99mTc-labeled chondroitin sulfate: A new approach of targeting osteoarthritis

(2007) Grazyna Sobal et al.   APPLIED RADIATION AND ISOTOPES