Article
Food Science & Technology
Rebecca Galla, Sara Ruga, Sara Ferrari, Sabrina Saccone, Laura Saccuman, Marco Invernizzi, Francesca Uberti
Summary: This study investigated the ability of a new plant-derived chondroitin to induce biological effects and found that it has unique chemical properties and biological significance, making it a promising new strategy for improving cartilage nutrition.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biophysics
Erlane de Sousa Araujo, Thiago Domingues Stocco, Gustavo Fernandes de Sousa, Samson Afewerki, Fernanda Roberta Marciano, Marcus Alexandre Finzi Corat, Mirian Michelle Machado de Paula, Thiago Ferreira Candido Lima Verde, Mayara Cristina Moreira Silva, Anderson Oliveira Lobo
Summary: Oxygen supply is crucial in cell culture for tissue engineering, and click chemistry offers a versatile approach for engineering hydrogels.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nutrition & Dietetics
Hongru Zhang, Liwei Qi, Qingshan Shen, Ruiqi Wang, Yujie Guo, Chunhui Zhang, Aurore Richel
Summary: This study investigates the therapeutic effects of bioactive compounds from chicken cartilage food supplements on osteoarthritis. The results show that oral chondroitin sulfate can improve athletic ability and reduce inflammatory cytokine levels in rats with osteoarthritis, indicating its potential as a treatment option.
FRONTIERS IN NUTRITION
(2022)
Review
Agriculture, Dairy & Animal Science
Silvia Fernandez-Martin, Antonio Gonzalez-Cantalapiedra, Fernando Munoz, Mario Garcia-Gonzalez, Maria Permuy, Monica Lopez-Pena
Summary: The use of nutraceuticals in the treatment of osteoarthritis remains controversial, with some studies showing positive effects under pre-emptive administrations and certain therapy combinations. However, more long-term and systematically designed studies are needed to verify these findings.
Article
Pharmacology & Pharmacy
Heba M. K. Ebada, Maha M. A. Nasra, Rasha A. Nassra, Ossama Y. Abdallah
Summary: The study implemented novel intra-articular nanoreservoirs using different cartilage targeting approaches to improve the bioavailability of a chondroprotective drug in cartilage. Active targeting approach via chondroitin sulfate functionalization showed superior efficacy in improving cartilage repair compared to passive targeting.
Article
Materials Science, Characterization & Testing
N. Rashidi, M. Tamaddon, C. Liu, J. Czernuszka
Summary: This study aimed to improve the application of chondroitin sulfate (CS) in tissue engineering and drug delivery devices by polymerizing it into a higher molecular weight polymer (PCS). The physicochemical properties of PCS were characterized and compared with CS, showing significant improvements in diameter and viscoelastic properties. These results suggest a great potential for using PCS in regenerative medicine devices.
Article
Biotechnology & Applied Microbiology
Donatella Cimini, Serena Boccella, Alberto Alfano, Antonietta Stellavato, Salvatore Paino, Chiara Schiraldi, Francesca Guida, Michela Perrone, Maria Donniacuo, Virginia Tirino, Vincenzo Desiderio, Barbara Rinaldi
Summary: This study aimed to explore the potential of biotechnological chondroitin in a mouse model of knee osteoarthritis. Results indicate that biotechnological chondroitin significantly reduced pain and decreased cartilage damage and inflammation in the osteoarthritis mouse model.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Alireza Savadipour, Robert J. Nims, Neda Rashidi, Jaquelin M. Garcia- Castorena, Ruhang Tang, Gabrielle K. Marushack, Sara J. Oswald, Wolfgang B. Liedtke, Farshid Guilak
Summary: Through AFM and FEM studies, we found that PIEZO1 and PIEZO2 mediate calcium (Ca2+) signaling in chondrocytes at moderately high levels of cellular deformation, while at the highest strains, PIEZO1 functions independently of PIEZO2. Biophysical factors that increase apparent chondrocyte membrane tension also enhance PIEZO1-driven Ca2+ signaling. We identified a threshold of membrane stretch ratio that leads to PIEZO1-induced chondrocyte mechanical injury, suggesting potential targets for osteoarthritis prevention or treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Atsushi Mori, Yukihiro Saito, Kazufumi Nakamura, Toshihiro Iida, Satoshi Akagi, Masashi Yoshida, Makiko Taniyama, Toru Miyoshi, Hiroshi Ito
Summary: Transthyretin cardiac amyloidosis (ATTR-CA) is associated with high uptake of Tc-99m-labeled bone tracer in the heart. However, the mechanism behind this uptake remains uncertain. This study compared Tc-99m-pyrophosphate (PYP) scintigraphy findings, endomyocardial biopsy (EMB) tissue findings, and the expression of bone metabolism-related genes in ATTR-CA, amyloid light-chain cardiac amyloidosis (AL-CA), and noncardiac amyloidosis (non-CA) patients. The results showed significantly higher uptake of Tc-99m-PYP in the hearts of ATTR-CA patients compared to AL-CA and non-CA patients. The ATTR-CA tissue had a higher percentage of von Kossa-positive microparticles, indicating calcification. However, there was no upregulation of bone metabolism-related genes in the ATTR-CA samples. Further investigation is needed to understand the mechanism of bone tracer uptake in the heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Priyanka Kothari, Ashish Kumar Tripathi, Aboli Girme, Divya Rai, Ruchi Singh, Shradha Sinha, Dharmendra Choudhary, Geet Kumar Nagar, Rakesh Maurya, Lal Hingorani, Ritu Trivedi
Summary: DS extract showed protective effects on joint cartilage and subchondral bone deterioration in vivo, while CAFG inhibited the effects induced by IL-1 beta and could be a potential therapeutic for treating osteoarthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Zhuoxuan Jia, Bijun Kang, Yizuo Cai, Chingyu Chen, Zheyuan Yu, Wei Li, Wenjie Zhang
Summary: The study found that CEFFE (a cell-free fat extract containing multiple cytokines) inhibits the progression of osteoarthritis by promoting cartilage regeneration and limiting joint inflammation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Surgery
Shani Goren, Nunzia Cinzia Paladino, Shachar Laks, Thomas Cuny, Josiane Vaillant-Lombard, Clement Mennetrey, Dan Assaf, Elif Hindie, Carole Guerin, Christelle Fargette, David Taieb, Frederic Sebag
Summary: F-18-FCH PET/CT, used as a second-line imaging technique, plays an accurate role in guiding minimally invasive parathyroidectomy. When combined with first-line imaging results, F-18-FCH PET/CT can better predict uniglandular diseases, leading to a higher success rate of minimally invasive surgery and maintaining exceptional cure rates.
WORLD JOURNAL OF SURGERY
(2022)
Article
Biophysics
Naghmeh Akbari Moghadam, Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad
Summary: Chitosan-chondroitin sulfate nanoparticles have been synthesized as a platform for efficient gene sequence delivery, showing potential for gene therapy in cartilage diseases.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Orthopedics
K. S. M. Reed, V. Ulici, C. Kim, S. Chubinskaya, R. F. Loeser, D. H. Phanstiel
Summary: Treatment of normal human articular chondrocytes with fibronectin fragments can recapitulate key aspects of the osteoarthritis chondrocyte phenotype, showing promising potential for future osteoarthritis studies, especially considering its compatibility with genomics and genome-editing techniques.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemistry & Molecular Biology
Carmen Nunez-Carro, Margarita Blanco-Blanco, Tatiana Montoya, Karla M. Villagran-Andrade, Tamara Hermida-Gomez, Francisco J. Blanco, Maria C. de Andres
Summary: Osteoarthritis is a chronic disease that affects articular cartilage and leads to its degeneration. Recent research has shown the importance of the interplay between inflammatory processes and epigenetic regulation in the development of osteoarthritis. However, the lack of specific protocols to extract histones from human articular cartilage has hindered further investigation in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)