Non-surgical Osteoarthritis Therapy, Intra-Articular Drug Delivery Toward Clinical Applications

Matrix mechanics and water permeation regulate extracellular vesicle transport

(2020) Stephen Lenzini et al.   Nature Nanotechnology

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

(2020) Saeid Safiri et al.   ANNALS OF THE RHEUMATIC DISEASES

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

(2020) Yujie Liang et al.   ACS Applied Materials & Interfaces

Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins

(2020) Armin Vedadghavami et al.   Nano Today

Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration

(2020) Xiao Xu et al.   BIOMATERIALS

Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis

(2019) Lan Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Intra-articular injection of hUC-MSCs expressing miR-140-5p induces cartilage self-repairing in the rat osteoarthritis

(2019) Yiyun Geng et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs

(2019) Tengfei He et al.   JOURNAL OF CONTROLLED RELEASE

Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis

(2019) Changsun Kang et al.   Nanomedicine-Nanotechnology Biology and Medicine

miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence

(2019) Hai-bo Si et al.   Molecular Therapy-Nucleic Acids

Gene therapy for repair and regeneration of bone and cartilage

(2018) Matthew W Grol et al.   CURRENT OPINION IN PHARMACOLOGY

Repair of articular cartilage defects with intra-articular injection of autologous rabbit synovial fluid-derived mesenchymal stem cells

(2018) Zhaofeng Jia et al.   Journal of Translational Medicine

INVOSSA, a first-in-class of cell and gene therapy for osteoarthritis treatment: the phase III trial

(2018) B. Lee   OSTEOARTHRITIS AND CARTILAGE

Effectiveness of intra‑articular ozone injections on outcomes of post‑arthroscopic surgery for knee osteoarthritis

(2018) Xiangjiang Wang et al.   Experimental and Therapeutic Medicine

Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model

(2018) Rachael S. Watson Levings et al.   Human Gene Therapy Clinical Development

Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues

(2018) Yamini Krishnan et al.   BIOMATERIALS

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

(2018) Brett C. Geiger et al.   Science Translational Medicine

Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats

(2017) H.-b. Si et al.   OSTEOARTHRITIS AND CARTILAGE

Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis

(2017) Kim L. Bennell et al.   Current Rheumatology Reports

Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis

(2016) Mi-Lan Kang et al.   Acta Biomaterialia

Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles

(2016) Jinming Li et al.   BIOMATERIALS

Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term

(2016) A.G. Bajpayee et al.   OSTEOARTHRITIS AND CARTILAGE

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

(2016) Huimin Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model

(2016) Gensheng Wang et al.   Molecular Therapy-Methods & Clinical Development

Intra-articular delivery of anti-Hif-2α siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice

(2015) Y Pi et al.   GENE THERAPY

Controlled Release of an Anti-inflammatory Drug Using an Ultrasensitive ROS-Responsive Gas-Generating Carrier for Localized Inflammation Inhibition

(2015) Ming-Fan Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration

(2014) Mi Lan Kang et al.   BIOMATERIALS

Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model

(2014) Ryuichiro Akagi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

(2013) Laurie R Goodrich et al.   Molecular Therapy-Nucleic Acids

Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteins

(2012) Rachel E. Whitmire et al.   BIOMATERIALS

Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

(2012) Chul-Won Ha et al.   CYTOTHERAPY

Analysis on the current status of targeted drug delivery to tumors

(2012) Il Keun Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits

(2010) Biao Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

HIF-2α as a possible therapeutic target of osteoarthritis

(2010) T. Saito et al.   OSTEOARTHRITIS AND CARTILAGE

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

(2009) Ginette Tardif et al.   BMC MUSCULOSKELETAL DISORDERS

Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus

(2009) Jesse D. Kay et al.   JOURNAL OF GENE MEDICINE

A single injection of anakinra for treating knee OA?

(2009) Johanne Martel-Pelletier et al.   Nature Reviews Rheumatology

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

(2008) Dominique A. Rothenfluh et al.   NATURE MATERIALS

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA

(2007) L.X. Chen et al.   OSTEOARTHRITIS AND CARTILAGE