Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

The role of macrophages in osteoarthritis and cartilage repair

(2020) C.-L. Wu et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular corticosteroid injections increase the risk of requiring knee arthroplasty

(2020) Stan R. W. Wijn et al.   Bone & Joint Journal

Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran

(2019) Pedro Renato de Paula Brandão et al.   Molecular Diagnosis & Therapy

Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival

(2018) Thomas A. Werfel et al.   CANCER RESEARCH

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes

(2018) Meredith A. Jackson et al.   BIOMATERIALS

A novel compressive stress-based osteoarthritis-like chondrocyte system

(2017) In-Chi Young et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis

(2017) Timothy E. McAlindon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Combinatorial optimization of PEG architecture and hydrophobic content improves ternary siRNA polyplex stability, pharmacokinetics, and potency in vivo

(2017) Thomas A. Werfel et al.   JOURNAL OF CONTROLLED RELEASE

Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury

(2017) Kristin P. O’Grady et al.   ACS Biomaterials-Science & Engineering

Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury

(2017) Kristin P. O’Grady et al.   ACS Biomaterials Science & Engineering

Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing

(2016) Samantha M. Sarett et al.   BIOMATERIALS

The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage

(2016) B. Sterner et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad

(2016) I. R. Klein-Wieringa et al.   JOURNAL OF RHEUMATOLOGY

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

MiRNA inhibition in tissue engineering and regenerative medicine

(2015) Kelsey R. Beavers et al.   ADVANCED DRUG DELIVERY REVIEWS

Platelet rich plasma enhances the immunohistochemical expression of platelet derived growth factor and vascular endothelial growth factor in the synovium of the meniscectomized rat models of osteoarthritis

(2015) Shaima M. Almasry et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Detection of early cartilage damage using targeted nanosomes in a post-traumatic osteoarthritis mouse model

(2015) Hongsik Cho et al.   Nanomedicine-Nanotechnology Biology and Medicine

Non-invasive mouse models of post-traumatic osteoarthritis

(2015) B.A. Christiansen et al.   OSTEOARTHRITIS AND CARTILAGE

TGF-β signal transduction pathways and osteoarthritis

(2015) Guangju Zhai et al.   RHEUMATOLOGY INTERNATIONAL

Intra-articular and soft tissue injections, a systematic review of relative efficacy of various corticosteroids

(2014) Neha Garg et al.   CLINICAL RHEUMATOLOGY

Total Knee Arthroplasty After Previous Knee Surgery

(2014) Robert H. Brophy et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Effects of enzymatic treatments on the depth-dependent viscoelastic shear properties of articular cartilage

(2014) Darvin J. Griffin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Future nanomedicine for the diagnosis and treatment of osteoarthritis

(2014) Lauren R Eichaker et al.   Nanomedicine

OARSI guidelines for the non-surgical management of knee osteoarthritis

(2014) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

(2013) Christopher E. Nelson et al.   ACS Nano

In Vivo Cyclic Compression Causes Cartilage Degeneration and Subchondral Bone Changes in Mouse Tibiae

(2013) Frank C. Ko et al.   ARTHRITIS AND RHEUMATISM

A current review of molecular mechanisms regarding osteoarthritis and pain

(2013) Andrew S. Lee et al.   GENE

Theranostic immunoliposomes for osteoarthritis

(2013) Hongsik Cho et al.   Nanomedicine-Nanotechnology Biology and Medicine

Progress in intra-articular therapy

(2013) Christopher H. Evans et al.   Nature Reviews Rheumatology

Osteoarthritis year in review 2013: biology

(2013) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis

(2013) M. Z. C. Ruan et al.   Science Translational Medicine

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Meniscal calcification, pathogenesis and implications

(2012) Yubo Sun et al.   CURRENT OPINION IN RHEUMATOLOGY

Integrin Targeted Delivery of Chemotherapeutics

(2012) Kai Chen et al.   Theranostics

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

(2012) Steven R. Goldring   Therapeutic Advances in Musculoskeletal Disease

A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis

(2011) M. Hayder et al.   Science Translational Medicine

Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis

(2010) P. Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

Characterizing a novel and adjustable noninvasive murine joint loading model

(2010) Blandine Poulet et al.   ARTHRITIS AND RHEUMATISM

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation pepti

(2010) Steven Settle et al.   ARTHRITIS AND RHEUMATISM

Epidemiology of Osteoarthritis

(2010) Yuqing Zhang et al.   CLINICS IN GERIATRIC MEDICINE

Rodent Preclinical Models for Developing Novel Antiarthritic Molecules: Comparative Biology and Preferred Methods for Evaluating Efficacy

(2010) Brad Bolon et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Genetic epidemiology of hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   Nature Reviews Rheumatology

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review

(2009) Stephanie Tanamas et al.   ARTHRITIS AND RHEUMATISM

Targeting Matrix Metalloproteinases in Inflammatory Conditions

(2009) A. Clutterbuck et al.   CURRENT DRUG TARGETS

Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells

(2009) Hongliang Cai et al.   TOXICOLOGY

Transcriptional regulators of chondrocyte hypertrophy

(2008) Lauren A. Solomon et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Intra‐articular depot formulation principles: Role in the management of postoperative pain and arthritic disorders

(2008) Claus Larsen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

(2008) Dominique A. Rothenfluh et al.   NATURE MATERIALS

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

(2008) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY