The dark side of homology-directed repair

PIF1 helicase promotes break‐induced replication in mammalian cells

(2021) Shibo Li et al.   EMBO JOURNAL

Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway

(2021) Benjamin M. Stinson et al.   Annual Review of Biochemistry

Replication dynamics of recombination-dependent replication forks

(2021) Karel Naiman et al.   Nature Communications

Repair of DNA Breaks by Break-Induced Replication

(2021) Z.W. Kockler et al.   Annual Review of Biochemistry

Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks

(2021) Nhung Pham et al.   EMBO JOURNAL

Structural parameters of palindromic repeats determine the specificity of nuclease attack of secondary structures

(2021) Anissia Ait Saada et al.   NUCLEIC ACIDS RESEARCH

Patterns of somatic structural variation in human cancer genomes

(2020) Yilong Li et al.   NATURE

BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence

(2020) Carlos Mendez-Dorantes et al.   Cell Reports

Chromothripsis and DNA Repair Disorders

(2020) Lusine Nazaryan-Petersen et al.   Journal of Clinical Medicine

Mechanistic basis for microhomology identification and genome scarring by polymerase theta

(2020) Juan Carvajal-Garcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MRE11 complex: A versatile toolkit for the repair of broken DNA

(2020) Giordano Reginato et al.   DNA REPAIR

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

(2020) J. A. Kamp et al.   Nature Communications

Interstitial telomere sequences disrupt break-induced replication and drive formation of ectopic telomeres

(2020) Elizabeth A Stivison et al.   NUCLEIC ACIDS RESEARCH

Dynamic Processing of Displacement Loops during Recombinational DNA Repair

(2019) Aurèle Piazza et al.   MOLECULAR CELL

Chromothripsis during telomere crisis is independent of NHEJ and consistent with a replicative origin

(2019) Kez Cleal et al.   GENOME RESEARCH

Homolog Dependent Repair Following Dicentric Chromosome Breakage in Drosophila melanogaster

(2019) Jayaram Bhandari et al.   GENETICS

Microhomology Selection for Microhomology Mediated End Joining in Saccharomyces cerevisiae

(2019) Kihoon Lee et al.   Genes

Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining

(2019) Joost Schimmel et al.   TRENDS IN GENETICS

The Drosophila melanogaster PIF1 Helicase Promotes Survival During Replication Stress and Processive DNA Synthesis During Double-Strand Gap Repair

(2019) Ece Kocak et al.   GENETICS

DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication

(2019) Roberto A. Donnianni et al.   MOLECULAR CELL

Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements

(2018) Carlos Mendez-Dorantes et al.   GENES & DEVELOPMENT

Replication Fork Breakage and Restart in Escherichia coli

(2018) Bénédicte Michel et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Single-strand annealing between inverted DNA repeats: Pathway choice, participating proteins, and genome destabilizing consequences

(2018) Sreejith Ramakrishnan et al.   PLoS Genetics

Sequence imperfections and base triplet recognition by the Rad51/RecA family of recombinases

(2017) Ja Yil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homology Requirements and Competition between Gene Conversion and Break-Induced Replication during Double-Strand Break Repair

(2017) Anuja Mehta et al.   MOLECULAR CELL

Mechanism of tandem duplication formation in BRCA1-mutant cells

(2017) Nicholas A. Willis et al.   NATURE

Rad51-mediated double-strand break repair and mismatch correction of divergent substrates

(2017) Ranjith Anand et al.   NATURE

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

(2017) Ying Wai Chan et al.   NATURE CELL BIOLOGY

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks

(2017) Ana Teixeira-Silva et al.   Nature Communications

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Eukaryotic DNA Polymerases in Homologous Recombination

(2016) Mitch McVey et al.   Annual Review of Genetics

Sgs1 and Mph1 Helicases Enforce the Recombination Execution Checkpoint During DNA Double-Strand Break Repair in Saccharomyces cerevisiae

(2016) Suvi Jain et al.   GENETICS

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

(2016) Jane C Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

(2016) Ragini Bhargava et al.   TRENDS IN GENETICS

The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

(2016) Jane C Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ontogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast

(2016) Tracey Beyer et al.   PLoS Genetics

Sgs1 and Mph1 Helicases Enforce the Recombination Execution Checkpoint During DNA Double-Strand Break Repair in Saccharomyces cerevisiae

(2016) Suvi Jain et al.   GENETICS

Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification

(2015) Sarah K. Deng et al.   MOLECULAR CELL

Top3-Rmi1 Dissolve Rad51-Mediated D Loops by a Topoisomerase-Based Mechanism

(2015) Clare L. Fasching et al.   MOLECULAR CELL

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mus81 and converging forks limit the mutagenicity of replication fork breakage

(2015) R. Mayle et al.   SCIENCE

Base triplet stepping by the Rad51/RecA family of recombinases

(2015) J. Y. Lee et al.   SCIENCE

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Contribution of Alu Elements to Mutagenic DNA Double-Strand Break Repair

(2015) Maria E. Morales et al.   PLoS Genetics

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

Chromosome rearrangements via template switching between diverged repeated sequences

(2014) Ranjith P. Anand et al.   GENES & DEVELOPMENT

Template Switching During Break-Induced Replication Is Promoted by the Mph1 Helicase inSaccharomyces cerevisiae

(2014) Anamarija Štafa et al.   GENETICS

Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

(2014) L. S. Symington et al.   GENETICS

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

(2014) Hind Ghezraoui et al.   MOLECULAR CELL

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

(2014) Nicholas A. Willis et al.   NATURE

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Dissolution of Double Holliday Junctions

(2014) A. H. Bizard et al.   Cold Spring Harbor Perspectives in Biology

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication

(2014) Soumini Vasan et al.   PLoS Genetics

DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

(2014) Christopher D. Putnam et al.   PLoS Genetics

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

(2013) Marenda A. Wilson et al.   NATURE

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Break-induced replication occurs by conservative DNA synthesis

(2013) R. A. Donnianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

High-Resolution Mapping of Spontaneous Mitotic Recombination Hotspots on the 1.1 Mb Arm of Yeast Chromosome IV

(2013) Jordan St. Charles et al.   PLoS Genetics

Overcoming the chromatin barrier to end resection

(2012) Huan Chen et al.   CELL RESEARCH

Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

(2012) Ken’Ichi Mizuno et al.   NATURE

Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations

(2012) Diana D. Villarreal et al.   PLoS Genetics

RAD51-independent inverted-repeat recombination by a strand-annealing mechanism

(2011) Christina Mott et al.   DNA REPAIR

Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genome

(2011) Claudia M B Carvalho et al.   NATURE GENETICS

Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells

(2011) J. R. LaRocque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Mus81 and Yen1 Promote Reciprocal Exchange during Mitotic Recombination to Maintain Genome Integrity in Budding Yeast

(2010) Chu Kwen Ho et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

(2010) Wael Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

(2010) Amy Marie Yu et al.   NUCLEIC ACIDS RESEARCH

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila

(2010) Sze Ham Chan et al.   PLoS Genetics

Cohesin Is Limiting for the Suppression of DNA Damage–Induced Recombination between Homologous Chromosomes

(2010) Shay Covo et al.   PLoS Genetics

Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

(2009) K. Mizuno et al.   GENES & DEVELOPMENT

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination

(2009) R. Prakash et al.   GENES & DEVELOPMENT

Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast

(2009) A. L. Paek et al.   GENES & DEVELOPMENT

Aberrant Double-Strand Break Repair Resulting in Half Crossovers in Mutants Defective for Rad51 or the DNA Polymerase   Complex

(2009) C. E. Smith et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms promoting translocations in editing and switching peripheral B cells

(2009) Jing H. Wang et al.   NATURE

Specific pathways prevent duplication-mediated genome rearrangements

(2009) Christopher D. Putnam et al.   NATURE

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

Analysis of repair mechanism choice during homologous recombination

(2009) Neta Agmon et al.   NUCLEIC ACIDS RESEARCH

Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules

(2009) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Defective Break-Induced Replication Leads to Half-Crossovers in Saccharomyces cerevisiae

(2008) A. Deem et al.   GENETICS

Microarray-Based Genetic Screen Defines SAW1, a Gene Required for Rad1/Rad10-Dependent Processing of Recombination Intermediates

(2008) Fuyang Li et al.   MOLECULAR CELL

Mus81-Dependent Double-Strand DNA Breaks at In Vivo-Generated Cruciform Structures in S. cerevisiae

(2008) Atina G. Coté et al.   MOLECULAR CELL

SbcCD Causes a Double-Strand Break at a DNA Palindrome in the Escherichia coli Chromosome

(2008) John K. Eykelenboom et al.   MOLECULAR CELL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

(2008) Kihoon Lee et al.   NATURE

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

(2008) W. Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

(2008) L. Liang et al.   NUCLEIC ACIDS RESEARCH

Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes

(2008) E. Rothenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-strand breaks associated with repetitive DNA can reshape the genome

(2008) J. L. Argueso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Segmental Duplications Arise from Pol32-Dependent Repair of Broken Forks through Two Alternative Replication-Based Mechanisms

(2008) Celia Payen et al.   PLoS Genetics

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics