Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair

(2017) Logan R. Myler et al.   MOLECULAR CELL

Rad51-mediated double-strand break repair and mismatch correction of divergent substrates

(2017) Ranjith Anand et al.   NATURE

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency

(2017) Ragini Bhargava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination

(2017) Ineke Brouwer et al.   Cell Reports

Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

(2017) Rachel W Anantha et al.   eLife

DNA Breaks and End Resection Measured Genome-wide by End Sequencing

(2016) Andres Canela et al.   MOLECULAR CELL

Mechanisms underlying structural variant formation in genomic disorders

(2016) Claudia M. B. Carvalho et al.   NATURE REVIEWS GENETICS

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination

(2016) David O. Onyango et al.   NUCLEIC ACIDS RESEARCH

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

(2016) Ragini Bhargava et al.   TRENDS IN GENETICS

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

(2016) Pauline Chanut et al.   Nature Communications

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination

(2016) Kritika Hanamshet et al.   Genes

A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae

(2015) U. Chakraborty et al.   GENETICS

The Contribution of Alu Elements to Mutagenic DNA Double-Strand Break Repair

(2015) Maria E. Morales et al.   PLoS Genetics

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells

(2014) Meilen C. Muñoz et al.   NUCLEIC ACIDS RESEARCH

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Quantitation of DNA double-strand break resection intermediates in human cells

(2013) Yi Zhou et al.   NUCLEIC ACIDS RESEARCH

Multiple cellular mechanisms prevent chromosomal rearrangements involving repetitive DNA

(2012) Carolyn M. George et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

(2012) Samuel F. Bunting et al.   MOLECULAR CELL

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Collaboration and competition between DNA double-strand break repair pathways

(2010) Elizabeth M. Kass et al.   FEBS LETTERS

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

All y’all need to know ‘bout retroelements in cancer

(2010) Victoria P. Belancio et al.   SEMINARS IN CANCER BIOLOGY

Structural transitions within human Rad51 nucleoprotein filaments

(2009) R. B. Robertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential

(2009) Nicole Bennardo et al.   PLoS Genetics

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics