Gene-Environment Interactions for Cardiovascular Disease

Taking a Stand Against Air Pollution—The Impact on Cardiovascular Disease

(2021) Michael Brauer et al.   CIRCULATION

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

(2021) Pradeep Natarajan et al.   Nature Communications

Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci

(2021) Michael Francis et al.   PLoS Genetics

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Inferring Gene-by-Environment Interactions with a Bayesian Whole-Genome Regression Model

(2020) Matthew Kerin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Efficient gene–environment interaction tests for large biobank‐scale sequencing studies

(2020) Xinyu Wang et al.   GENETIC EPIDEMIOLOGY

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

(2020) Satoshi Koyama et al.   NATURE GENETICS

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

(2020) Jaana A Hartiala et al.   EUROPEAN HEART JOURNAL

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

(2019) Tuomas O. Kilpeläinen et al.   Nature Communications

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

(2019) Amy R. Bentley et al.   NATURE GENETICS

Gene-Environment Interaction in the Era of Precision Medicine

(2019) Jingjing Li et al.   CELL

A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers

(2019) Cavin K. Ward-Caviness   HUMAN GENETICS

A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

(2019) Yun Ju Sung et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study of peripheral artery disease in the Million Veteran Program

(2019) Derek Klarin et al.   NATURE MEDICINE

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

(2019) Huanwei Wang et al.   Science Advances

Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease

(2019) Elvezia Maria Paraboschi et al.   HAEMATOLOGICA

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

(2019) Rubina Tabassum et al.   Nature Communications

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity

(2019) Hadi Maazi et al.   PLoS Genetics

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

(2018) Yun J. Sung et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Exome Chip Analysis Identifies Low-Frequency and Rare Variants inMRPL38for White Matter Hyperintensities on Brain Magnetic Resonance Imaging

(2018) Xueqiu Jian et al.   STROKE

Alterations of Hyaluronan Metabolism in Acute Coronary Syndrome

(2018) Daniela Pedicino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Genome-wide Association Study of Susceptibility to Particulate Matter–Associated QT Prolongation

(2017) Rahul Gondalia et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Overview of the BioBank Japan Project: Study design and profile

(2017) Akiko Nagai et al.   JOURNAL OF EPIDEMIOLOGY

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

(2017) Derek Klarin et al.   NATURE GENETICS

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation

(2017) John Eicher et al.   THROMBOSIS AND HAEMOSTASIS

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic

(2017) Cavin K. Ward-Caviness et al.   PLoS One

Genotypic Context and Epistasis in Individuals and Populations

(2016) Timothy B. Sackton et al.   CELL

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

(2016) Sophie Hellstrand et al.   Genes and Nutrition

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

(2016) Aldons J. Lusis et al.   JOURNAL OF LIPID RESEARCH

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

(2016) Jaana A. Hartiala et al.   Nature Communications

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis

(2016) Christina Loley et al.   Scientific Reports

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

(2016) Sophie Hellstrand et al.   Genes and Nutrition

Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease

(2016) Cavin K. Ward-Caviness et al.   PLoS One

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Environmental factors in cardiovascular disease

(2015) Kristen E. Cosselman et al.   Nature Reviews Cardiology

ADAMTS7 Cleavage and Vascular Smooth Muscle Cell Migration Is Affected by a Coronary-Artery-Disease-Associated Variant

(2013) Xiangyuan Pu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimation and Partition of Heritability in Human Populations Using Whole-Genome Analysis Methods

(2013) Anna A.E. Vinkhuyzen et al.   Annual Review of Genetics

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

(2013) Brian W. Parks et al.   Cell Metabolism

Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations

(2012) Steve Bevan et al.   STROKE

Health Effects of Light and Intermittent Smoking

(2010) Rebecca E. Schane et al.   CIRCULATION

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

(2009) Sekar Kathiresan et al.   NATURE GENETICS

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE