A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

(2019) Amy R. Bentley et al.   NATURE GENETICS

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

(2018) Yun J. Sung et al.   AMERICAN JOURNAL OF HUMAN GENETICS

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

(2018) Paul K. Whelton et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

(2018) Ayush Giri et al.   NATURE GENETICS

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

(2017) Helen R Warren et al.   NATURE GENETICS

Genes, Environment, and the Heart

(2017) Edwin P. Kirk   Circulation-Cardiovascular Genetics

Multiancestry Study of Gene–Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 CohortsCLINICAL PERSPECTIVE

(2017) D. C. Rao et al.   Circulation-Cardiovascular Genetics

International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and AdolescentsCLINICAL PERSPECTIVE

(2016) Priyakumari Ganesh Parmar et al.   Circulation-Cardiovascular Genetics

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group

(2016) Yun Ju Sung et al.   GENETIC EPIDEMIOLOGY

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

(2016) Chunyu Liu et al.   NATURE GENETICS

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

(2016) Georg B Ehret et al.   NATURE GENETICS

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and AdolescentsCLINICAL PERSPECTIVE

(2016) Priyakumari Ganesh Parmar et al.   Circulation-Cardiovascular Genetics

Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With BrachydactylyNovelty and Significance

(2015) Okan Toka et al.   HYPERTENSION

Right Ventricular Myocardial Biomarkers in Human Heart Failure

(2015) Thomas G. di Salvo et al.   JOURNAL OF CARDIAC FAILURE

PDE3A mutations cause autosomal dominant hypertension with brachydactyly

(2015) Philipp G Maass et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Common Genetic Variations in the Vitamin D Pathway in Relation to Blood Pressure

(2014) Lu Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data

(2014) Thomas W. Winkler et al.   BIOINFORMATICS

Upregulation of sestrin-2 expression protects against endothelial toxicity of angiotensin II

(2014) Lao Yi et al.   CELL BIOLOGY AND TOXICOLOGY

Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy

(2014) Christina A. Markunas et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Sestrin2 Decreases Renal Oxidative Stress, Lowers Blood Pressure, and Mediates Dopamine D 2 Receptor–Induced Inhibition of Reactive Oxygen Species Production

(2014) Yu Yang et al.   HYPERTENSION

Quality control and conduct of genome-wide association meta-analyses

(2014) Thomas W Winkler et al.   Nature Protocols

Differences in smoking associated DNA methylation patterns in South Asians and Europeans

(2014) Hannah R Elliott et al.   Clinical Epigenetics

Large‐Scale Gene‐Centric Analysis Identifies Polymorphisms for Resistant Hypertension

(2014) Vanessa Fontana et al.   Journal of the American Heart Association

Gene × Environment Interaction Studies Have Not Properly Controlled for Potential Confounders: The Problem and the (Simple) Solution

(2013) Matthew C. Keller   BIOLOGICAL PSYCHIATRY

Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics

(2013) Caitrin W. McDonough et al.   JOURNAL OF HYPERTENSION

Familial pheochromocytomas and paragangliomas

(2013) Kathryn S. King et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

(2013) Ching-Ti Liu et al.   PLoS Genetics

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

(2013) Joshua C. Randall et al.   PLoS Genetics

Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9

(2013) Jeannette Simino et al.   Frontiers in Genetics

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

Thrombospondin-4 Is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle

(2011) Oscar H. Cingolani et al.   CIRCULATION RESEARCH

On the Robustness of Tests of Genetic Associations Incorporating Gene-environment Interaction When the Environmental Exposure is Misspecified

(2011) Eric J. Tchetgen Tchetgen et al.   EPIDEMIOLOGY

Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability

(2011) Zoltán Kutalik et al.   GENETIC EPIDEMIOLOGY

Genome-Wide Meta-Analysis of Joint Tests for Genetic and Gene-Environment Interaction Effects

(2011) Hugues Aschard et al.   HUMAN HEREDITY

Identification of Evidence Suggestive of an Association with Peripheral Arterial Disease at the OSBPL10 Locus by Genome-Wide Investigation in the Japanese Population

(2011) Hiroshi Koriyama et al.   Journal of Atherosclerosis and Thrombosis

Phosphodiesterase 3A (PDE3A) Deletion Suppresses Proliferation of Cultured Murine Vascular Smooth Muscle Cells (VSMCs) via Inhibition of Mitogen-activated Protein Kinase (MAPK) Signaling and Alterations in Critical Cell Cycle Regulatory Proteins

(2011) Najma Begum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction

(2011) Arend Voorman et al.   PLoS One

Genome-Wide Detection of Allele Specific Copy Number Variation Associated with Insulin Resistance in African Americans from the HyperGEN Study

(2011) Marguerite R. Irvin et al.   PLoS One

Association Between NEDD4L Gene and Sodium Lithium Countertransport

(2010) Xiaojing Zheng et al.   AMERICAN JOURNAL OF HYPERTENSION

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

ProbABEL package for genome-wide association analysis of imputed data

(2010) Yurii S Aulchenko et al.   BMC BIOINFORMATICS

Low penetrance of a SDHB mutation in a large Dutch paraganglioma family

(2010) Frederik J Hes et al.   BMC Medical Genetics

Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients

(2010) Alisa K. Manning et al.   GENETIC EPIDEMIOLOGY

A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients

(2010) Patrik Svensson-Färbom et al.   JOURNAL OF HYPERTENSION

Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations

(2010) Coro Paisán-Ruiz et al.   MOVEMENT DISORDERS

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis

(2010) Sandra Luecke et al.   Pigment Cell & Melanoma Research

Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++

(2010) Eugene V. Davydov et al.   PLoS Computational Biology

Molecular Genetics of Addiction and Related Heritable Phenotypes

(2009) George R. Uhl et al.   Annals of the New York Academy of Sciences

Identifying novel constrained elements by exploiting biased substitution patterns

(2009) Manuel Garber et al.   BIOINFORMATICS

Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

(2009) Gary L. Pierce et al.   CIRCULATION

Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations

(2009) Elin Org et al.   HUMAN MOLECULAR GENETICS

A Functional Variant of NEDD4L Is Associated With Hypertension, Antihypertensive Response, and Orthostatic Hypotension

(2009) Fang Luo et al.   HYPERTENSION

Genetic Variants Associated With Cardiac Structure and Function

(2009) Ramachandran S. Vasan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts

(2009) K-W Hong et al.   JOURNAL OF HUMAN HYPERTENSION

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

(2007) Linh P. Nguyen et al.   CHEMICAL RESEARCH IN TOXICOLOGY