Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses

(2015) Ayşe Demirkan et al.   PLoS Genetics

Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry

(2014) Zeneng Wang et al.   ANALYTICAL BIOCHEMISTRY

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

(2014) Jaana Hartiala et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

(2014) Diana M. Shih et al.   JOURNAL OF LIPID RESEARCH

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Genetic Determinants Influencing Human Serum Metabolome among African Americans

(2014) Bing Yu et al.   PLoS Genetics

Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke

(2014) Stephen R. Williams et al.   PLoS Genetics

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

(2013) Joyce BJ van Meurs et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Glycine metabolism in animals and humans: implications for nutrition and health

(2013) Weiwei Wang et al.   AMINO ACIDS

Toward New Biomarkers of Cardiometabolic Diseases

(2013) Lee D. Roberts et al.   Cell Metabolism

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort

(2013) Eugene P. Rhee et al.   Cell Metabolism

Homoarginine Levels Are Regulated by l -Arginine:Glycine Amidinotransferase and Affect Stroke Outcome

(2013) Chi-un Choe et al.   CIRCULATION

Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

(2013) Maria Sabater-Lleal et al.   CIRCULATION

Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine

(2013) Marcus E. Kleber et al.   Circulation-Cardiovascular Genetics

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

(2013) W. Xie et al.   DIABETES

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia

(2013) Alexander P. Reiner et al.   HUMAN MOLECULAR GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk

(2012) W.H. Wilson Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase

(2012) Emilee Senkevitch et al.   MOLECULAR GENETICS AND METABOLISM

Clinical and Genetic Association of Serum Ceruloplasmin With Cardiovascular Risk

(2011) W.H. Wilson Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cysteine, histidine and glycine exhibit anti-inflammatory effects in human coronary arterial endothelial cells

(2011) S. Hasegawa et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort

(2011) D. M. Greenawalt et al.   GENOME RESEARCH

Genetic contribution of the leukotriene pathway to coronary artery disease

(2011) Jaana Hartiala et al.   HUMAN GENETICS

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

(2011) A Schröder et al.   PHARMACOGENOMICS JOURNAL

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers

(2011) Kirstin Mittelstrass et al.   PLoS Genetics

Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

(2011) Federico Innocenti et al.   PLoS Genetics

The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism

(2010) Michael Lever et al.   CLINICAL BIOCHEMISTRY

Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults

(2010) Leslie A. Lange et al.   HUMAN MOLECULAR GENETICS

New loci associated with kidney function and chronic kidney disease

(2010) Anna Köttgen et al.   NATURE GENETICS

Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population

(2009) Guillaume Paré et al.   Circulation-Cardiovascular Genetics

Novel Loci, Including Those Related to Crohn Disease, Psoriasis, and Inflammation, Identified in a Genome-Wide Association Study of Fibrinogen in 17 686 Women

(2009) Jacqueline S. Danik et al.   Circulation-Cardiovascular Genetics

Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk

(2009) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular Risk

(2008) Tamali Bhattacharyya   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

(2008) Goro KIKUCHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Mapping the Genetic Architecture of Gene Expression in Human Liver

(2008) Eric E Schadt et al.   PLOS BIOLOGY