Morinda officinalis oligosaccharides alleviate depressive‐like behaviors in post‐stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation

Potential microglia‐based interventions for stroke

(2020) Ling‐Zhi Li et al.   CNS Neuroscience & Therapeutics

Hypertonic saline mediates the NLRP3/IL‐1β signaling axis in microglia to alleviate ischemic blood‐brain barrier permeability by downregulating astrocyte‐derived VEGF in rats

(2020) Qiao‐sheng Wang et al.   CNS Neuroscience & Therapeutics

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

(2020) Nathalie Percie du Sert et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia

(2020) Dai-Chao Ma et al.   EXPERIMENTAL NEUROLOGY

Morinda officinalis oligosaccharides ameliorate depressive‐like behaviors in poststroke rats through upregulating GLUT3 to improve synaptic activity

(2020) Jiayi Zhu et al.   FASEB JOURNAL

The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

(2020) Maximilian Franke et al.   BRAIN BEHAVIOR AND IMMUNITY

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

(2019) Judith Houtman et al.   EMBO JOURNAL

Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway

(2019) Xin Jin et al.   CNS Neuroscience & Therapeutics

Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus

(2019) Lin-Lin Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Inulin with a low degree of polymerization protects human umbilical vein endothelial cells from hypoxia/reoxygenation-induced injury

(2019) Xuexiang Cha et al.   CARBOHYDRATE POLYMERS

Extracellular ASC exacerbated the recurrent ischemic stroke in an NLRP3-dependent manner

(2019) Xiao-fei He et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

(2019) Xiujing Feng et al.   Frontiers in Molecular Neuroscience

Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease

(2019) Md. Ezazul Haque et al.   MOVEMENT DISORDERS

Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?

(2019) Xi Tao et al.   EXPERIMENTAL NEUROLOGY

Morinda officinalis How. – A comprehensive review of traditional uses, phytochemistry and pharmacology

(2018) Jian-hua Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Post-stroke depression: Mechanisms and pharmacological treatment

(2018) Roberto Federico Villa et al.   PHARMACOLOGY & THERAPEUTICS

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke

(2018) Luting Poh et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

(2018) Martin Dennis et al.   LANCET

Does depression after stroke negatively influence physical disability? A systematic review and meta-analysis of longitudinal studies

(2018) Maria Blöchl et al.   JOURNAL OF AFFECTIVE DISORDERS

Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke

(2017) Chih-Hao Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test

(2017) Filipe Marques Gonçalves et al.   JOURNAL OF NEURAL TRANSMISSION

Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

(2017) Mengmeng Li et al.   Journal of Neuroinflammation

Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis

(2017) Elles Douven et al.   NEUROPSYCHOLOGY REVIEW

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

The Extracts of Morinda officinalis and Its Hairy Roots Attenuate Dextran Sodium Sulfate-Induced Chronic Ulcerative Colitis in Mice by Regulating Inflammation and Lymphocyte Apoptosis

(2017) Jian Liang et al.   Frontiers in Immunology

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 inflammasome: a promising target in ischemic stroke

(2016) Li Gao et al.   INFLAMMATION RESEARCH

Effects of interleukin-6, interleukin-18, and statin use, evaluated at acute stroke, on post-stroke depression during 1-year follow-up

(2016) Hee-Ju Kang et al.   PSYCHONEUROENDOCRINOLOGY

Overexpression of brain-derived neurotrophic factor in the hippocampus protects against post-stroke depression

(2015) Xiao-yan Fu et al.   Neural Regeneration Research

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Part I: Frequency of Depression after Stroke: An Updated Systematic Review and Meta-Analysis of Observational Studies

(2014) Maree L. Hackett et al.   International Journal of Stroke

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at the chronic stage

(2014) Svitlana Garbuzova-Davis et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Screening, Diagnosis, and Treatment of Post-Stroke Depression

(2014) Kimberly Dwyer Hollender   JOURNAL OF NEUROSCIENCE NURSING

Effect of oxytocin on the behavioral activity in the behavioral despair depression rat model

(2014) Yuan Yan et al.   NEUROPEPTIDES

The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery

(2014) Johan Dahl et al.   PSYCHONEUROENDOCRINOLOGY

Long-axis specialization of the human hippocampus

(2013) Jordan Poppenk et al.   TRENDS IN COGNITIVE SCIENCES

Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-κB inactivation

(2012) Ji-Sun Shin et al.   FOOD AND CHEMICAL TOXICOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

(2012) Marie Kim Wium-Andersen et al.   JAMA Psychiatry

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

Structural Features of Ischemic Damage in the Hippocampus

(2009) Alexander G. Nikonenko et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study

(2008) Fabiano G. Nery et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Anhedonia and activity deficits in rats: impact of post-stroke depression

(2008) SH Wang et al.   JOURNAL OF PSYCHOPHARMACOLOGY