Radio Signals from Live Cells: The Coming of Age of In-Cell Solution NMR

Danio rerio Oocytes for Eukaryotic In-Cell NMR

(2021) Joseph F. Thole et al.   BIOCHEMISTRY

Protein in-cell NMR spectroscopy at 1.2 GHz

(2021) Enrico Luchinat et al.   JOURNAL OF BIOMOLECULAR NMR

The intracellular environment affects protein–protein interactions

(2021) Shannon L. Speer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of X-ray absorption and X-ray fluorescence techniques to the study of metallodrug action

(2021) James H. Lovett et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

50 years of PDB: a catalyst in structural biology

(2021) Alexandre M. J. J. Bonvin   NATURE METHODS

Rapid protein delivery to living cells for biomolecular investigation

(2021) Francesco Torricella et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Determination of intracellular protein–ligand binding affinity by competition binding in-cell NMR

(2021) Enrico Luchinat et al.   Acta Crystallographica Section D-Structural Biology

Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency

(2020) Enrico Luchinat et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

What does fluorine do to a protein? Thermodynamic, and highly-resolved structural insights into fluorine-labelled variants of the cold shock protein

(2020) Hannah Welte et al.   Scientific Reports

In-vitro NMR Studies of Prostate Tumor Cell Metabolism by Means of Hyperpolarized [1-13C]Pyruvate Obtained Using the PHIP-SAH Method

(2020) Eleonora Cavallari et al.   Frontiers in Oncology

Real-Time Quantitative In-Cell NMR: Ligand Binding and Protein Oxidation Monitored in Human Cells Using Multivariate Curve Resolution

(2020) Enrico Luchinat et al.   ANALYTICAL CHEMISTRY

Enabling NMR studies of high molecular weight systems without the need for deuteration: The XL‐ALSOFAST experiment with delayed decoupling

(2020) Philip Rößler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Active metabolism unmasks functional protein–protein interactions in real time in-cell NMR

(2020) Leonard Breindel et al.   Communications Biology

Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR

(2020) Enrico Luchinat et al.   ACS Chemical Biology

In‐cell NMR of functional riboswitch aptamers in eukaryotic cells

(2020) P. Broft et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS

(2020) Qingci Zhao et al.   Cell Reports

Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR

(2019) Panagis Polykretis et al.   Redox Biology

High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells

(2019) Takashi Tanaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Positively Charged Tags Impede Protein Mobility in Cells as Quantified by 19F NMR

(2019) Yansheng Ye et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Trends in clinical success rates and therapeutic focus

(2019) Helen Dowden et al.   NATURE REVIEWS DRUG DISCOVERY

DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells

(2019) Siddarth Narasimhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In-cell EPR: progress towards structural studies inside cells

(2019) Alessio Bonucci et al.   CHEMBIOCHEM

Observing an antisense drug complex in intact human cells by in-cell NMR

(2019) Judith Schlagnitweit et al.   CHEMBIOCHEM

Monitoring DNA–Ligand Interactions in Living Human Cells Using NMR Spectroscopy

(2019) Michaela Krafcikova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FRET as a biomolecular research tool — understanding its potential while avoiding pitfalls

(2019) W. Russ Algar et al.   NATURE METHODS

Methyl TROSY spectroscopy: A versatile NMR approach to study challenging biological systems

(2019) Stefan Schütz et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Detection, identification, and quantification of oxidative protein modifications

(2019) Clare L. Hawkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Unified Description of Intrinsically Disordered Protein Dynamics under Physiological Conditions Using NMR Spectroscopy

(2019) Wiktor Adamski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Real-Time NMR Spectroscopy for Studying Metabolism

(2019) Islam Alshamleh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In-Cell NMR in Human Cells: Direct Protein Expression Allows Structural Studies of Protein Folding and Maturation

(2018) Enrico Luchinat et al.   ACCOUNTS OF CHEMICAL RESEARCH

Potent Inhibitors of Mycobacterium tuberculosis Growth Identified by Using in-Cell NMR-based Screening

(2018) Christopher M. DeMott et al.   ACS Chemical Biology

Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells

(2018) Simon Dzatko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Real-Time In-Cell Nuclear Magnetic Resonance: Ribosome-Targeted Antibiotics Modulate Quinary Protein Interactions

(2018) Leonard Breindel et al.   BIOCHEMISTRY

Production of isotope-labeled proteins in insect cells for NMR

(2018) Bastian Franke et al.   JOURNAL OF BIOMOLECULAR NMR

Balanced Regulation of Redox Status of Intracellular Thioredoxin Revealed by in-Cell NMR

(2018) Ayano Mochizuki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The first successful observation of in-cell NMR signals of DNA and RNA in living human cells

(2018) Yudai Yamaoki et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

(2018) Michael J. Capper et al.   Nature Communications

In-cell NMR within budding yeast reveals cytoplasmic masking of hydrophobic residues of FG repeats

(2018) Kathryn P. Wall et al.   BIOPHYSICAL JOURNAL

Probing the interaction of a quercetin bioconjugate with Bcl-2 in living human cancer cells with in-cell NMR spectroscopy

(2018) Alexandra Primikyri et al.   FEBS LETTERS

A Dual-App Nucleoside Probe Provides Structural Insights into the Human Telomeric Overhang in Live Cells

(2018) Sudeshna Manna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Visualizing and discovering cellular structures with super-resolution microscopy

(2018) Yaron M. Sigal et al.   SCIENCE

Target Engagement and Binding Mode of an Antituberculosis Drug to Its Bacterial Target Deciphered in Whole Living Cells by NMR

(2018) Guillaume Bouvier et al.   BIOCHEMISTRY

Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions

(2018) Linda Cerofolini et al.   BIOPHYSICAL JOURNAL

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau

(2018) Shengnan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Data Bank: the single global archive for 3D macromolecular structure data

(2018) et al.   NUCLEIC ACIDS RESEARCH

Development of a bioreactor system for cytotoxic evaluation of pharmacological compounds in living cells using NMR spectroscopy

(2018) Josué Carvalho et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

(2018) Matthew J. Reilley et al.   Journal for ImmunoTherapy of Cancer

Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site

(2017) Morgan M. Fetherolf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular metal binding and redox behavior of human DJ-1

(2017) Letizia Barbieri et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Osmotic Shock Induced Protein Destabilization in Living Cells and Its Reversal by Glycine Betaine

(2017) Samantha S. Stadmiller et al.   JOURNAL OF MOLECULAR BIOLOGY

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

(2017) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

Physicochemical code for quinary protein interactions inEscherichia coli

(2017) Xin Mu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinary interactions with an unfolded state ensemble

(2017) Rachel D. Cohen et al.   PROTEIN SCIENCE

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

(2017) Enrico Luchinat et al.   Scientific Reports

Fluorine nuclear magnetic resonance-based assay in living mammalian cells

(2016) Marina Veronesi et al.   ANALYTICAL BIOCHEMISTRY

Total Cellular RNA Modulates Protein Activity

(2016) Subhabrata Majumder et al.   BIOCHEMISTRY

Sequential protein expression and selective labeling for in-cell NMR in human cells

(2016) Enrico Luchinat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Direct structural evidence of protein redox regulation obtained by in-cell NMR

(2016) Eleonora Mercatelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

(2016) Mohammed Kaplan et al.   CELL

3D structure determination of a protein in living cells using paramagnetic NMR spectroscopy

(2016) Bin-Bin Pan et al.   CHEMICAL COMMUNICATIONS

Cell signaling regulation by protein phosphorylation: a multivariate, heterogeneous, and context-dependent process

(2016) Evan K Day et al.   CURRENT OPINION IN BIOTECHNOLOGY

Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

(2016) Mie Kristensen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Perspective: revisiting the field dependence of TROSY sensitivity

(2016) Koh Takeuchi et al.   JOURNAL OF BIOMOLECULAR NMR

Algal autolysate medium to label proteins for NMR in mammalian cells

(2016) Carmelo Fuccio et al.   JOURNAL OF BIOMOLECULAR NMR

A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells

(2016) Yuya Hikone et al.   JOURNAL OF BIOMOLECULAR NMR

On the present and future of dissolution-DNP

(2016) Jan Henrik Ardenkjaer-Larsen   JOURNAL OF MAGNETIC RESONANCE

Pseudocontact Shift-Driven Iterative Resampling for 3D Structure Determinations of Large Proteins

(2016) Kala Bharath Pilla et al.   JOURNAL OF MOLECULAR BIOLOGY

In-Cell Protein Structures from 2D NMR Experiments

(2016) Thomas Müntener et al.   Journal of Physical Chemistry Letters

Electrostatic Contributions to Protein Quinary Structure

(2016) Rachel D. Cohen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells

(2016) Letizia Barbieri et al.   Nature Protocols

In-cell thermodynamics and a new role for protein surfaces

(2016) Austin E. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex

(2016) Barak Raveh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail?

(2016) Martin Beck et al.   TRENDS IN CELL BIOLOGY

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

(2016) Andres Binolfi et al.   Nature Communications

Metal Cations in G-Quadruplex Folding and Stability

(2016) Debmalya Bhattacharyya et al.   Frontiers in Chemistry

Improved in-cell structure determination of proteins at near-physiological concentration

(2016) Teppei Ikeya et al.   Scientific Reports

Real-Time Monitoring of Cancer Cell Metabolism and Effects of an Anticancer Agent using 2D In-Cell NMR Spectroscopy

(2015) He Wen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Observation of Ca2+-Induced Calmodulin Conformational Transitions in IntactXenopus laevisOocytes by19F NMR Spectroscopy

(2015) Yansheng Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target-Based Whole-Cell Screening by1H NMR Spectroscopy

(2015) Junhe Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing Protein Quinary Interactions by In-Cell Nuclear Magnetic Resonance Spectroscopy

(2015) Subhabrata Majumder et al.   BIOCHEMISTRY

Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus

(2015) Kendra K. Frederick et al.   CELL

Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors

(2015) Sigrid Milles et al.   CELL

Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1

(2015) E. Luchinat et al.   CHEMICAL COMMUNICATIONS

Labeling Strategy and Signal Broadening Mechanism of Protein NMR Spectroscopy inXenopus laevisOocytes

(2015) Yansheng Ye et al.   CHEMISTRY-A EUROPEAN JOURNAL

Non-uniform sampling: post-Fourier era of NMR data collection and processing

(2015) Krzysztof Kazimierczuk et al.   MAGNETIC RESONANCE IN CHEMISTRY

Correction for Monteith and Pielak, Residue level quantification of protein stability in living cells

(2015)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamics of protein destabilization in live cells

(2015) Jens Danielsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinary structure modulates protein stability in cells

(2015) William B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen exchange of disordered proteins inEscherichia coli

(2015) Austin E. Smith et al.   PROTEIN SCIENCE

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

(2015) David Hong et al.   Science Translational Medicine

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

(2015) Sean J. Humphrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy

(2015) Gilmar F. Salgado et al.   Chemical Science

Caught in Action: Selecting Peptide Aptamers Against Intrinsically Disordered Proteins in Live Cells

(2015) Jacqueline D. Cobbert et al.   Scientific Reports

Protein interaction patterns in different cellular environments are revealed by in-cell NMR

(2015) Letizia Barbieri et al.   Scientific Reports

The RCSB PDB “Molecule of the Month”: Inspiring a Molecular View of Biology

(2015) David S. Goodsell et al.   PLOS BIOLOGY

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

(2015) Loren E Hough et al.   eLife

Nonuniform Sampling and Maximum Entropy Reconstruction in Multidimensional NMR

(2014) Jeffrey C. Hoch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production

(2014) Mudassar Ahmad et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Strategies for Protein NMR in Escherichia coli

(2014) Guohua Xu et al.   BIOCHEMISTRY

Structural insights of proteins in sub-cellular compartments: In-mitochondria NMR

(2014) Letizia Barbieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Using Singular Value Decomposition to Characterize Protein-Protein Interactions by In-cell NMR Spectroscopy

(2014) Subhabrata Majumder et al.   CHEMBIOCHEM

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

DJ-1 Is a Copper Chaperone Acting on SOD1 Activation

(2014) Stefania Girotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

(2014) Gilbert Richarme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel methods based on 13C detection to study intrinsically disordered proteins

(2014) Isabella C. Felli et al.   JOURNAL OF MAGNETIC RESONANCE

Hyperpolarized [U-2H, U-13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells

(2014) Kerstin N. Timm et al.   MAGNETIC RESONANCE IN MEDICINE

In-cell 13C NMR spectroscopy for the study of intrinsically disordered proteins

(2014) Isabella C Felli et al.   Nature Protocols

Residue level quantification of protein stability in living cells

(2014) W. B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific ion effects on macromolecular interactions inEscherichia coliextracts

(2014) Ciara Kyne et al.   PROTEIN SCIENCE

In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants

(2014) Enrico Luchinat et al.   Nature Communications

An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca2+ concentration in HeLa cells

(2013) Dambarudhar Shiba Sankar Hembram et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K+ Solution

(2013) Herry Martadinata et al.   BIOCHEMISTRY

Multi-phosphorylation of the Intrinsically Disordered Unique Domain of c-Src Studied by In-Cell and Real-Time NMR Spectroscopy

(2013) Irene Amata et al.   CHEMBIOCHEM

Quantitative comparison of protein dynamics in live cells and in vitro by in-cell 19F-NMR

(2013) Yousuke Takaoka et al.   CHEMICAL COMMUNICATIONS

Effects of Molecular Crowding on the Structures, Interactions, and Functions of Nucleic Acids

(2013) Shu-ichi Nakano et al.   CHEMICAL REVIEWS

Visualization of Redox-Controlled Protein Fold in Living Cells

(2013) Lucia Banci et al.   CHEMISTRY & BIOLOGY

19F NMR Spectroscopy as a Probe of Cytoplasmic Viscosity and Weak Protein Interactions in Living Cells

(2013) Yansheng Ye et al.   CHEMISTRY-A EUROPEAN JOURNAL

In Vitro Assays Predictive of Telomerase Inhibitory Effect of G-Quadruplex Ligands in Cell Nuclei

(2013) Hidenobu Yaku et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Crowding Drives Active Pin1 into Nonspecific Complexes with Endogenous Proteins Prior to Substrate Recognition

(2013) Laura M. Luh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-Resolution Heteronuclear Multidimensional NMR of Proteins in Living Insect Cells Using a Baculovirus Protein Expression System

(2013) Jumpei Hamatsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pruning the ALS-Associated Protein SOD1 for in-Cell NMR

(2013) Jens Danielsson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic-resolution monitoring of protein maturation in live human cells by NMR

(2013) Lucia Banci et al.   Nature Chemical Biology

Hyperpolarized13C NMR studies of glucose metabolism in living breast cancer cell cultures

(2013) T. Harris et al.   NMR IN BIOMEDICINE

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

(2013) Christopher A. Waudby et al.   PLoS One

Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR

(2013) Andres Y. Maldonado et al.   PLoS One

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Three-Dimensional Protein Fold Determination from Backbone Amide Pseudocontact Shifts Generated by Lanthanide Tags at Multiple Sites

(2013) Hiromasa Yagi et al.   STRUCTURE

Protein dynamics elucidated by NMR technique

(2013) Conggang Li et al.   Protein & Cell

A Gel-Encapsulated Bioreactor System for NMR Studies of Protein-Protein Interactions in Living Mammalian Cells

(2012) Satoshi Kubo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

(2012) Andres Binolfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

In-Cell Solid-State NMR as a Tool to Study Proteins in Large Complexes

(2012) Sina Reckel et al.   CHEMBIOCHEM

Simple and inexpensive incorporation of 19F-Tryptophan for protein NMR spectroscopy

(2012) Peter B. Crowley et al.   CHEMICAL COMMUNICATIONS

A New Algorithm for Reliable and General NMR Resonance Assignment

(2012) Elena Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Proteins in Eukaryotic Compartments

(2012) Karl Bertrand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Distinction of Intracellular and Extracellular Proteins Using NMR Diffusion Measurements

(2012) Christopher A. Waudby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction of α-Synuclein and a Cell Penetrating Fusion Peptide with Higher Eukaryotic Cell Membranes Assessed by 19F NMR

(2012) Imola G. Zigoneanu et al.   MOLECULAR PHARMACEUTICS

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized13C NMR

(2012) Crystal Harrison et al.   NMR IN BIOMEDICINE

Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS)

(2012) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular solid-state nuclear magnetic resonance spectroscopy

(2012) M. Renault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Oxygen Concentration on Viability and Metabolism in a Fluidized-Bed Bioartificial Liver Using 31P and 13C NMR Spectroscopy

(2012) Rex E. Jeffries et al.   TISSUE ENGINEERING PART C-METHODS

13C Direct-Detection Biomolecular NMR Spectroscopy in Living Cells

(2011) Ivano Bertini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

(2011) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Exploring Weak, Transient Protein–Protein Interactions in Crowded In Vivo Environments by In-Cell Nuclear Magnetic Resonance Spectroscopy

(2011) Qinghua Wang et al.   BIOCHEMISTRY

Protein Interactions in the Escherichia coli Cytosol: An Impediment to In-Cell NMR Spectroscopy

(2011) Peter B. Crowley et al.   CHEMBIOCHEM

STD and trNOESY NMR Study of Receptor-Ligand Interactions in Living Cancer Cells

(2011) Donatella Potenza et al.   CHEMBIOCHEM

Real-time detection of central carbon metabolism in livingEscherichia coliand its response to perturbations

(2011) Sebastian Meier et al.   FEBS LETTERS

Equivalent Pulse Parameters for Electroporation

(2011) G. Pucihar et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Methods to determine slow diffusion coefficients of biomolecules. Applications to Engrailed 2, a partially disordered protein

(2011) Rafal Augustyniak et al.   JOURNAL OF BIOMOLECULAR NMR

Protein Crowding Tunes Protein Stability

(2011) Andrew C. Miklos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macromolecular Crowding Fails To Fold a Globular Protein in Cells

(2011) Alexander P. Schlesinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic pathway visualization in living yeast by DNP-NMR

(2011) Sebastian Meier et al.   Molecular BioSystems

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

In-cell NMR in E. coli to Monitor Maturation Steps of hSOD1

(2011) Lucia Banci et al.   PLoS One

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2D TR-NOESY Experiments Interrogate and Rank Ligand-Receptor Interactions in Living Human Cancer Cells

(2010) Silvia Mari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cadmium stress: an oxidative challenge

(2010) Ann Cuypers et al.   BIOMETALS

Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure

(2010) Rodrigo S Chaves et al.   BMC NEUROSCIENCE

Internal and Global Protein Motion Assessed with a Fusion Construct and In-Cell NMR Spectroscopy

(2010) Christopher O. Barnes et al.   CHEMBIOCHEM

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

15NH/D-SOLEXSY experiment for accurate measurement of amide solvent exchange rates: application to denatured drkN SH3

(2010) Veniamin Chevelkov et al.   JOURNAL OF BIOMOLECULAR NMR

Electrospray Mass Spectrometry of Telomeric RNA (TERRA) Reveals the Formation of Stable Multimeric G-Quadruplex Structures

(2010) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyperpolarized13C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism

(2010) Kayvan R. Keshari et al.   MAGNETIC RESONANCE IN MEDICINE

Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import

(2010) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria, reactive oxygen species and cadmium toxicity in the kidney

(2010) Glenda Gobe et al.   TOXICOLOGY LETTERS

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

Biotechnological strains of Komagataella (Pichia) pastoris are Komagataella phaffii as determined from multigene sequence analysis

(2009) Cletus Paul Kurtzman   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A bioreactor for in-cell protein NMR

(2009) Naima G. Sharaf et al.   JOURNAL OF MAGNETIC RESONANCE

Screening of Small Molecule Interactor Library by Using In-Cell NMR Spectroscopy (SMILI-NMR)

(2009) Jingjing Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of Parameters Critical for Observing Nucleic Acids Inside LivingXenopus laevisOocytes by In-Cell NMR Spectroscopy

(2009) Robert Hänsel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Observation of NMR Signals from Proteins Introduced into Living Mammalian Cells by Reversible Membrane Permeabilization Using a Pore-Forming Toxin, Streptolysin O

(2009) Shinji Ogino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein19F NMR inEscherichia coli

(2009) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein structure determination in living cells by in-cell NMR spectroscopy

(2009) Daisuke Sakakibara et al.   NATURE

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

(2009) Kohsuke Inomata et al.   NATURE

Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

(2009) Lucia Banci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells

(2009) T. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cadmium and cellular signaling cascades: To be or not to be?

(2009) Frank Thévenod   TOXICOLOGY AND APPLIED PHARMACOLOGY

Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes

(2008) Julian Leon Huppert   CHEMICAL SOCIETY REVIEWS

Alternate HMQC experiments for recording HN and HC-correlation spectra in proteins at high throughput

(2008) Luciano Mueller   JOURNAL OF BIOMOLECULAR NMR

Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages

(2008) David B. Berkowitz et al.   JOURNAL OF FLUORINE CHEMISTRY

Investigation of endogenous antigen processing by delivery of an intact protein into cells

(2008) Hongmei Fu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

NMR observation of Tau in Xenopus oocytes

(2008) Jean-François Bodart et al.   JOURNAL OF MAGNETIC RESONANCE

NMR bioreactor development for live in-situ microbial functional analysis

(2008) Paul D. Majors et al.   JOURNAL OF MAGNETIC RESONANCE

Differential Dynamical Effects of Macromolecular Crowding on an Intrinsically Disordered Protein and a Globular Protein: Implications for In-Cell NMR Spectroscopy

(2008) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

(2008) Philipp Selenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In-Cell Biochemistry Using NMR Spectroscopy

(2008) David S. Burz et al.   PLoS One

Hydrogen exchange of monomeric α-synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding inEscherichia coli

(2008) Robyn L. Croke et al.   PROTEIN SCIENCE

Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides

(2007) Ikuhiko Nakase et al.   ADVANCED DRUG DELIVERY REVIEWS

The design of guanidinium-rich transporters and their internalization mechanisms

(2007) Paul A. Wender et al.   ADVANCED DRUG DELIVERY REVIEWS