Amino Reactivity of Glutardialdehyde and Monoaldehydes─Chemoassay Profile vs Skin Sensitization Potency

Pred-Skin: A Web Portal for Accurate Prediction of Human Skin Sensitizers

(2020) Joyce V. B. Borba et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients

(2020) Nicola Gilmour et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers

(2020) Zhengxi Wei et al.   TOXICOLOGY LETTERS

Validation of the GARD™skin assay for assessment of chemical skin sensitizers – ring trial results of predictive performance and reproducibility

(2019) Henrik Johansson et al.   TOXICOLOGICAL SCIENCES

Chemo- and Regioselective Lysine Modification on Native Proteins

(2018) Maria J. Matos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism-informed read-across assessment of skin sensitizers based on SkinSensDB

(2018) Chun-Wei Tung et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Deriving a No Expected Sensitization Induction Level for Fragrance Ingredients Without Animal Testing: An Integrated Approach Applied to Specific Case Studies

(2018) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

A Perspective and a New Integrated Computational Strategy for Skin Sensitization Assessment

(2018) Vinicius M. Alves et al.   ACS Sustainable Chemistry & Engineering

Computational approaches for skin sensitization prediction

(2018) Anke Wilm et al.   CRITICAL REVIEWS IN TOXICOLOGY

Targeting the N terminus for site-selective protein modification

(2017) Christian B Rosen et al.   Nature Chemical Biology

Prediction of skin sensitization potency sub-categories using peptide reactivity data

(2017) Britta Wareing et al.   TOXICOLOGY IN VITRO

SkinSensDB: a curated database for skin sensitization assays

(2017) Chia-Chi Wang et al.   Journal of Cheminformatics

State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies

(2016) Janine Ezendam et al.   ARCHIVES OF TOXICOLOGY

Chemoavailability of Organic Electrophiles: Impact of Hydrophobicity and Reactivity on Their Aquatic Excess Toxicity

(2016) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Reaction Chemistry to Characterize the Molecular Initiating Event in Skin Sensitization: A Journey to Be Continued

(2016) Andreas Natsch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhalation threshold of toxicological concern (TTC) — Structural alerts discriminate high from low repeated-dose inhalation toxicity

(2016) Gerrit Schüürmann et al.   ENVIRONMENT INTERNATIONAL

Multivariate models for prediction of human skin sensitization hazard

(2016) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Integrated decision strategies for skin sensitization hazard

(2016) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Evaluation of combinations ofin vitrosensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization

(2015) Morihiko Hirota et al.   JOURNAL OF APPLIED TOXICOLOGY

Optimization of the IL-8 Luc assay as an in vitro test for skin sensitization

(2015) Yutaka Kimura et al.   TOXICOLOGY IN VITRO

The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization

(2015) Cécile Piroird et al.   TOXICOLOGY IN VITRO

Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals

(2014) Jochem W. van der Veen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

LuSens: A keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification

(2014) Tzutzuy Ramirez et al.   TOXICOLOGY IN VITRO

A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation

(2013) Andreas Natsch et al.   JOURNAL OF APPLIED TOXICOLOGY

The Nature of Nurture: Refining the Definition of the Exposome

(2013) Gary W. Miller et al.   TOXICOLOGICAL SCIENCES

Chemoassay Screening of DNA-Reactive Mutagenicity with 4-(4-Nitrobenzyl)pyridine – Application to Epoxides, Oxetanes, and Sulfur Heterocycles

(2012) Diana Thaens et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chemical Reactivity and Skin Sensitization Potential for Benzaldehydes: Can Schiff Base Formation Explain Everything?

(2012) Andreas Natsch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Relating Skin Sensitizing Potency to Chemical Reactivity: Reactive Michael Acceptors Inhibit NF-κB Signaling and Are Less Sensitizing than SNAr- and SN2- Reactive Chemicals

(2011) Andreas Natsch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology

(2011) Romualdo Benigni et al.   CHEMICAL REVIEWS

A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

(2011) S. J. Enoch et al.   CRITICAL REVIEWS IN TOXICOLOGY

DNA damage induced by endogenous aldehydes: Current state of knowledge

(2011) Georgia-Persephoni Voulgaridou et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Large shifts in pKa values of lysine residues buried inside a protein

(2011) D. G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiol Reactivity and Its Impact on the Ciliate Toxicity of α,β-Unsaturated Aldehydes, Ketones, and Esters

(2010) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A review of the electrophilic reaction chemistry involved in covalent DNA binding

(2010) S. J. Enoch et al.   CRITICAL REVIEWS IN TOXICOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Environment and Disease Risks

(2010) S. M. Rappaport et al.   SCIENCE

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Kinetic Glutathione Chemoassay To Quantify Thiol Reactivity of Organic ElectrophilesApplication to α,β-Unsaturated Ketones, Acrylates, and Propiolates

(2009) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Electrophilic Reaction Chemistry of Low Molecular Weight Respiratory Sensitizers

(2009) Steven J. Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

High Throughput Kinetic Profiling Approach for Covalent Binding to Peptides: Application to Skin Sensitization Potency of Michael Acceptor Electrophiles

(2009) David W. Roberts et al.   CHEMICAL RESEARCH IN TOXICOLOGY