Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins

The cellular function of SCAP in metabolic signaling

(2020) Sun Hee Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Accessibility of cholesterol at cell surfaces

(2020) Kristen A. Johnson et al.   JOURNAL OF LIPID RESEARCH

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

(2020) Michael E. Abrams et al.   Nature Microbiology

Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome

(2020) Wei-Yuan Hsieh et al.   Cell Metabolism

Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins

(2020) Quan D. Zhou et al.   NATURE IMMUNOLOGY

Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities

(2020) Jin Zhao et al.   Viruses-Basel

Interaction of Macrophages and Cholesterol-Dependent Cytolysins: The Impact on Immune Response and Cellular Survival

(2020) Roshan Thapa et al.   Toxins

Lipid Rafts and Pathogens: The Art of Deception and Exploitation

(2019) Michael I Bukrinsky et al.   JOURNAL OF LIPID RESEARCH

The ins and outs of lipid rafts: Functions in intracellular cholesterol homeostasis, microparticles, and cell membranes

(2019) Amber B Ouweneel et al.   JOURNAL OF LIPID RESEARCH

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

25-hydroxycholesterol Production by Interferon Stimulated Gene Cholesterol-25-hydroxylase Restricts Mammalian Reovirus Infection.

(2018) Alexandra Doms et al.   JOURNAL OF VIROLOGY

Immune oxysterols: Role in mycobacterial infection and inflammation

(2017) Saikou Y. Bah et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

(2017) Elisa Araldi et al.   Cell Reports

Manipulation of Host Cholesterol by Obligate Intracellular Bacteria

(2017) Dhritiman Samanta et al.   Frontiers in Cellular and Infection Microbiology

Macrophage–Bacteria Interactions—A Lipid-Centric Relationship

(2017) Ooiean Teng et al.   Frontiers in Immunology

The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments

(2017) Elvis Pandzic et al.   Scientific Reports

Srebp2: A master regulator of sterol and fatty acid synthesis

(2016) Blair B. Madison   JOURNAL OF LIPID RESEARCH

Role of lipids in the metabolism and activation of immune cells

(2016) Merla J. Hubler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Switch-like Responses of Two Cholesterol Sensors Do Not Require Protein Oligomerization in Membranes

(2015) Austin Gay et al.   BIOPHYSICAL JOURNAL

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production

(2015) Maria Angela M. Marques et al.   JOURNAL OF BACTERIOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis

(2015) Hongjin Lu et al.   STEROIDS

Interaction of pathogens with host cholesterol metabolism

(2014) Dmitri Sviridov et al.   CURRENT OPINION IN LIPIDOLOGY

Molecular Mechanisms of Cellular Cholesterol Efflux

(2014) Michael C. Phillips   JOURNAL OF BIOLOGICAL CHEMISTRY

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells

(2013) A. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

More Than a Pore: The Cellular Response to Cholesterol-Dependent Cytolysins

(2013) Sara Cassidy et al.   Toxins

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

Obesity and the risk and outcome of infection

(2012) R Huttunen et al.   INTERNATIONAL JOURNAL OF OBESITY

The burden of obesity on infectious disease

(2011) Erik A Karlsson et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Metabolic Shifts in Immunity and Inflammation

(2010) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Acyl-coenzyme A:cholesterol acyltransferases

(2009) Ta-Yuan Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular Pathogenesis of Necrotizing Fasciitis

(2009) Randall J. Olsen et al.   Annual Review of Pathology-Mechanisms of Disease

TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation

(2009) Lei Lei et al.   JOURNAL OF LIPID RESEARCH

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity

(2009) Sandipan Chatterjee et al.   PLoS One

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase

(2008) Russell A DeBose-Boyd   CELL RESEARCH

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA