Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Limits to human neurogenesis—really?

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Expression of neurogenic markers in Alzheimer’s disease: A systematic review and meta-transcriptional analysis

(2019) Ariana Gatt et al.   NEUROBIOLOGY OF AGING

Recalibrating the Relevance of Adult Neurogenesis

(2019) Jason S. Snyder   TRENDS IN NEUROSCIENCES

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

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MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

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Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Human Adult Neurogenesis: Evidence and Remaining Questions

(2018) Gerd Kempermann et al.   Cell Stem Cell

Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer’s Disease Adults

(2018) Sara Cipriani et al.   CEREBRAL CORTEX

The role of adult hippocampal neurogenesis in brain health and disease

(2018) Tomohisa Toda et al.   MOLECULAR PSYCHIATRY

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing

(2018) Hannah Hochgerner et al.   NATURE NEUROSCIENCE

Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates

(2018) Pedro Baptista et al.   Frontiers in Neuroanatomy

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

A Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer's Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls

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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain

(2018) Alexandria N. Tartt et al.   Cell Stem Cell

Does Adult Neurogenesis Persist in the Human Hippocampus?

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Tumor suppressors BTG1 and BTG2: Beyond growth control

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Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector

(2018) Hoonkyo Suh et al.   Frontiers in Molecular Neuroscience

microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer’s disease

(2017) Evgenia Salta et al.   FASEB JOURNAL

Redundant and incoherent regulations of multiple phenotypes suggest microRNAs’ role in stability control

(2017) Zhongqi Liufu et al.   GENOME RESEARCH

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

(2017) Ellis Patrick et al.   Molecular Neurodegeneration

Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood

(2017) Christoph Anacker et al.   NATURE REVIEWS NEUROSCIENCE

Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease

(2017) Yang Wang et al.   NEUROBIOLOGY OF AGING

The miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster

(2017) Sabrina Pichler et al.   NEUROBIOLOGY OF AGING

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains

(2017) Michiel van Boxelaere et al.   PLoS One

Rho GTPases as therapeutic targets in Alzheimer’s disease

(2017) Byron J. Aguilar et al.   Alzheimers Research & Therapy

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression

(2017) M Egeland et al.   Translational Psychiatry

MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer’s disease

(2016) Qiong-Bin Zhu et al.   BRAIN

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

(2016) Evgenia Salta et al.   EMBO Molecular Medicine

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

(2016) Richard S Finkel et al.   LANCET

Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits

(2016) Kathleen M. McAvoy et al.   NEURON

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding

(2016) Nathan B. Danielson et al.   NEURON

Preserved neurogenesis in non-demented individuals with AD neuropathology

(2016) David Briley et al.   Scientific Reports

Memory formation and retention are affected in adult miR-132/212 knockout mice

(2015) Julia Hernandez-Rapp et al.   BEHAVIOURAL BRAIN RESEARCH

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregationin vivo

(2015) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging

(2015) Etsuo A Susaki et al.   Nature Protocols

miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity

(2015) Michael J. Moore et al.   Nature Communications

Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice

(2015) Zsuzsanna Callaerts-Vegh et al.   Frontiers in Behavioral Neuroscience

COMPREHENSIVE GENE-GENE INTERACTION META-ANALYSIS OF IGAP GWA STUDIES

(2014) Tim Becker et al.   Alzheimers & Dementia

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

A Self-Organizing miR-132/Ctbp2 Circuit Regulates Bimodal Notch Signals and Glial Progenitor Fate Choice during Spinal Cord Maturation

(2014) Evgenia Salta et al.   DEVELOPMENTAL CELL

Wnt5a-Rac1-NF- B Homeostatic Circuitry Sustains Innate Immune Functions in Macrophages

(2014) D. Naskar et al.   JOURNAL OF IMMUNOLOGY

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Toward a unified therapeutics approach targeting putative amyloid-  oligomer receptors

(2014) C. R. Overk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Performance on a pattern separation task by Alzheimer’s patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels

(2014) Keith A Wesnes et al.   Alzheimers Research & Therapy

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Pattern separation and pattern completion in Alzheimer's disease: Evidence of rapid forgetting in amnestic mild cognitive impairment

(2013) Brandon A. Ally et al.   HIPPOCAMPUS

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

(2013) Hon-Kit Andus Wong et al.   HUMAN MOLECULAR GENETICS

CaMKI  Regulates AMP Kinase-Dependent, TORC-1-Independent Autophagy during Lipopolysaccharide-Induced Acute Lung Neutrophilic Inflammation

(2013) L. Guo et al.   JOURNAL OF IMMUNOLOGY

Stage-Specific Functions of the Small Rho GTPases Cdc42 and Rac1 for Adult Hippocampal Neurogenesis

(2013) K. C. Vadodaria et al.   JOURNAL OF NEUROSCIENCE

Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches

(2013) Almudena Fuster-Matanzo et al.   MEDIATORS OF INFLAMMATION

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

Alterations of Ca2+-responsive proteins within cholinergic neurons in aging and Alzheimer's disease

(2013) David Riascos et al.   NEUROBIOLOGY OF AGING

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease

(2013) Per Johansson et al.   PSYCHONEUROENDOCRINOLOGY

Amyloid-β1–42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2

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National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

miRNA-132: a dynamic regulator of cognitive capacity

(2012) Katelin F. Hansen et al.   Brain Structure & Function

Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion

(2012) Toshiaki Nakashiba et al.   CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis

(2012) Yu-Ting Yang et al.   NATURE NEUROSCIENCE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region

(2012) Yosuke Niibori et al.   Nature Communications

miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132

(2011) Eva M. Jimenez-Mateos et al.   AMERICAN JOURNAL OF PATHOLOGY

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

miR-132 Mediates the Integration of Newborn Neurons into the Adult Dentate Gyrus

(2011) Bryan W. Luikart et al.   PLoS One

Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans

(2010) R. Coras et al.   BRAIN

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Long-Term Potentiation-Dependent Spine Enlargement Requires Synaptic Ca2+-Permeable AMPA Receptors Recruited by CaM-Kinase I

(2010) D. A. Fortin et al.   JOURNAL OF NEUROSCIENCE

High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

(2010) Michael A. Yassa et al.   NEUROIMAGE

Single-Cell Optogenetic Excitation Drives Homeostatic Synaptic Depression

(2010) Carleton P. Goold et al.   NEURON

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

(2010) Dieter Edbauer et al.   NEURON

Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years

(2010) Rolf Knoth et al.   PLoS One

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

(2010) S. T. Magill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies

(2009) Alexander Garthe et al.   PLoS One

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

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