MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

Noncoding RNAs in Alzheimer's disease

(2018) M. Laura Idda et al.   Wiley Interdisciplinary Reviews-RNA

A Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer's Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls

(2018) Sébastien S. Hébert et al.   JOURNAL OF ALZHEIMERS DISEASE

microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer’s disease

(2017) Evgenia Salta et al.   FASEB JOURNAL

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

(2017) Ellis Patrick et al.   Molecular Neurodegeneration

Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease

(2017) Yang Wang et al.   NEUROBIOLOGY OF AGING

The miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster

(2017) Sabrina Pichler et al.   NEUROBIOLOGY OF AGING

miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions

(2017) Chih-Hung Chou et al.   NUCLEIC ACIDS RESEARCH

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease

(2017) Rached Alkallas et al.   Nature Communications

Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies

(2017) Fulvio Florenzano et al.   Oncotarget

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

(2016) Evgenia Salta et al.   EMBO Molecular Medicine

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes

(2016) Ji-Ann Lee et al.   NEURON

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

(2016) Ksenia Kurbatskaya et al.   Acta Neuropathologica Communications

microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice

(2016) Julia Hernandez-Rapp et al.   Scientific Reports

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregationin vivo

(2015) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers

(2015) Adam Cantlon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death

(2015) D. Kanmert et al.   JOURNAL OF NEUROSCIENCE

Regulation of Neuronal Cell Cycle and Apoptosis by miR-34a

(2015) Prashant Kumar Modi et al.   MOLECULAR AND CELLULAR BIOLOGY

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Divergent CSF   alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy

(2014) D. Wagshal et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

(2014) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

BDNF Promotes Axon Branching of Retinal Ganglion Cells via miRNA-132 and p250GAP

(2014) Katharine J. Marler et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

CDK5 activator protein p25 preferentially binds and activates GSK3β

(2014) Hei-Man Chow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

(2013) Luis Valor et al.   CURRENT PHARMACEUTICAL DESIGN

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

(2013) Hon-Kit Andus Wong et al.   HUMAN MOLECULAR GENETICS

iCLIP: Protein–RNA interactions at nucleotide resolution

(2013) Ina Huppertz et al.   METHODS

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures

(2013) Myrrhe van Spronsen et al.   PLoS One

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

(2013) Jere E. Meredith Jr. et al.   PLoS One

TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways

(2012) A. S. Chen-Plotkin et al.   JOURNAL OF NEUROSCIENCE

miR-212/132 expression and functions: within and beyond the neuronal compartment

(2012) A. Wanet et al.   NUCLEIC ACIDS RESEARCH

DNA methylation silences miR-132 in prostate cancer

(2012) A Formosa et al.   ONCOGENE

Early Mechanisms of Pathobiology Are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice

(2012) Anna Majer et al.   PLoS Pathogens

MicroRNA networks direct neuronal development and plasticity

(2011) N. F. M. Olde Loohuis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy

(2011) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2011) Adriana Ferreira et al.   MOLECULAR MEDICINE

The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

(2011) Lauren T Gehman et al.   NATURE GENETICS

miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity

(2011) Nikolaos Mellios et al.   NATURE NEUROSCIENCE

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

Implicating Calpain in Tau-Mediated Toxicity In Vivo

(2011) James B. Reinecke et al.   PLoS One

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

(2010) S. T. Magill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γ-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons

(2009) Aedín M. Minogue et al.   BRAIN RESEARCH

A facile method for expression and purification of the Alzheimer’s disease-associated amyloid β-peptide

(2009) Dominic M. Walsh et al.   FEBS Journal

Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus

(2008) T. H. Davis et al.   JOURNAL OF NEUROSCIENCE

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

(2008) Sébastien S. Hébert et al.   NEUROBIOLOGY OF DISEASE

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

(2008) Shuxin Hu et al.   NEUROBIOLOGY OF DISEASE

An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP

(2008) Gary A. Wayman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA expression in the adult mouse central nervous system

(2008) M. Bak et al.   RNA