Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Therapeutic Potential of Mesenchymal Stem Cells and Their Products in Lung Diseases—Intravenous Administration versus Inhalation

(2021) Eleonore Fröhlich   Pharmaceutics

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti‐inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury

(2020) Gabriela Viegas Haute et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation

(2020) Luchan Deng et al.   Cell Death & Disease

Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic Influenza A (H7N9) infection, a hint for COVID-19 treatment

(2020) Jiajia Chen et al.   Engineering

Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis

(2020) Xiu-wu Pan et al.   INTENSIVE CARE MEDICINE

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Lung Injury in COVID-19—An Emerging Hypothesis

(2020) Abdulrahman Alharthy et al.   ACS Chemical Neuroscience

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Platelet Gene Expression and Function in COVID-19 Patients

(2020) Bhanu Kanth Manne et al.   BLOOD

Single-cell landscape of immunological responses in patients with COVID-19

(2020) Ji-Yuan Zhang et al.   NATURE IMMUNOLOGY

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities

(2020) Louis Maximilian Buja et al.   CARDIOVASCULAR PATHOLOGY

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

(2020) Jun Wang et al.   Frontiers in Immunology

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19

(2020) Henry Ng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

(2020) Vivek Verma et al.   NATURE IMMUNOLOGY

Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models

(2019) Maname Benyelles et al.   EMBO Molecular Medicine

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

(2019) Aleksandar Ivetic et al.   Frontiers in Immunology

Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice

(2019) Yanyan Yan et al.   Aging-US

SNV identification from single-cell RNA sequencing data

(2019) Patricia M Schnepp et al.   HUMAN MOLECULAR GENETICS

Mesenchymal Stem Cells Loaded with Gelatin Microcryogels Attenuate Renal Fibrosis

(2019) Xiaodong Geng et al.   Biomed Research International

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

(2019) Carl Randall Harrell et al.   Cells

Kindlin-3 negatively regulates the release of neutrophil extracellular traps

(2018) Zhen Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mesenchymal stem cells improves survival in LPS-induced acute lung injury acting through inhibition of NETs formation

(2017) Leonardo Pedrazza et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade

(2016) Peter J.R. Ebert et al.   IMMUNITY

Interaction of kindlin-3 and  2-integrins differentially regulates neutrophil recruitment and NET release in mice

(2015) Z. Xu et al.   BLOOD

GPI-80 Defines Self-Renewal Ability in Hematopoietic Stem Cells during Human Development

(2015) Sacha Leandra Prashad et al.   Cell Stem Cell

Immunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation

(2015) Philipp Nold et al.   CYTOTHERAPY

Sca-1+Lin−CD117−Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IRF8-Controlled Regulatory Dendritic Cells through Notch–RBP-J Signaling

(2015) Xingxia Liu et al.   JOURNAL OF IMMUNOLOGY

G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent

(2014) Linda J. Bendall et al.   CYTOKINE & GROWTH FACTOR REVIEWS

HMGB1 in Cancer: Good, Bad, or Both?

(2013) R. Kang et al.   CLINICAL CANCER RESEARCH

An obligate cell-intrinsic function for CD28 in Tregs

(2013) Ruan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

(2013) Ying Xim Tan et al.   NATURE IMMUNOLOGY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of CX3CL1/CX3CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental hepatopulmonary syndrome

(2012) Junlan Zhang et al.   JOURNAL OF HEPATOLOGY

Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IL-10-Dependent Regulatory Dendritic Cells by SOCS3 Activation

(2012) X. Liu et al.   JOURNAL OF IMMUNOLOGY

Isogenic mesenchymal stem cells transplantation improves a rat model of chronic aristolochic acid nephropathy via upregulation of hepatic growth factor and downregulation of transforming growth factor β1

(2012) Wei Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization

(2010) A M Greenbaum et al.   LEUKEMIA

The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR   and NKG2D

(2009) Y. Kong et al.   BLOOD

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

(2009) Wei Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population

(2008) B. Zhang et al.   BLOOD

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE