Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

(2020) Alexander Duscha et al.   CELL

How microbiota shape microglial phenotypes and epigenetics

(2020) Daniel Erny et al.   GLIA

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

(2020) Charlotte Mezö et al.   Acta Neuropathologica Communications

The microbiota‐microglia axis in CNS disorders

(2020) Omar Mossad et al.   BRAIN PATHOLOGY

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Acetate Promotes T Cell Effector Function during Glucose Restriction

(2019) Jing Qiu et al.   Cell Reports

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

Metabolic adaptations of tissue-resident immune cells

(2019) George Caputa et al.   NATURE IMMUNOLOGY

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring

(2018) Daniel Stoessel et al.   Frontiers in Human Neuroscience

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

(2018) Moumita Datta et al.   IMMUNITY

A chemical derivatization based UHPLC-LTQ-Orbitrap mass spectrometry method for accurate quantification of short-chain fatty acids in bronchoalveolar lavage fluid of asthma mice

(2018) Ying-Ying Jin et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

(2018) Alida Kindt et al.   Nature Communications

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

(2018) David E. Sanin et al.   IMMUNITY

Microglia metabolism in health and disease

(2018) Katharina Borst et al.   NEUROCHEMISTRY INTERNATIONAL

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbiology: Gut microbes augment neurodegeneration

(2017) Daniel Erny et al.   NATURE

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Metabolism and acetylation in innate immune cell function and fate

(2016) Alanna M. Cameron et al.   SEMINARS IN IMMUNOLOGY

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

(2015) Alicia A. Babcock et al.   BRAIN BEHAVIOR AND IMMUNITY

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses

(2015) Ruijie Liu et al.   NUCLEIC ACIDS RESEARCH

Myeloid Cells in Alzheimer's Disease: Culprits, Victims or Innocent Bystanders?

(2015) Melanie Meyer-Luehmann et al.   TRENDS IN NEUROSCIENCES

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

(2011) Jenni Raasch et al.   BRAIN

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE