Glycogen accumulation and phase separation drives liver tumor initiation

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability

(2020) Laura B. Persson et al.   CELL

Protein Phase Separation as a Stress Survival Strategy

(2019) Titus M. Franzmann et al.   Cold Spring Harbor Perspectives in Biology

FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

(2019) Suyuan Ji et al.   DEVELOPMENTAL CELL

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers

(2019) Ramon C. Sun et al.   Cell Metabolism

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes

(2019) Megan A. Altemus et al.   PLoS One

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

(2019) David T. McSwiggen et al.   GENES & DEVELOPMENT

Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications

(2019) Zhe Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

(2019) Iván M. Moya et al.   SCIENCE

Role of the transcriptional coactivators YAP/TAZ in liver cancer

(2019) Shihao Zhang et al.   CURRENT OPINION IN CELL BIOLOGY

A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

(2018) Jing Cai et al.   GENES & DEVELOPMENT

A User’s Guide for Phase Separation Assays with Purified Proteins

(2018) Simon Alberti et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

(2018) Marion Curtis et al.   Cell Metabolism

Lafora disease — from pathogenesis to treatment strategies

(2018) Felix Nitschke et al.   Nature Reviews Neurology

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy

(2017) Goo-Young Kim et al.   HUMAN MOLECULAR GENETICS

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

(2017) Changmin Peng et al.   MOLECULAR CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy

(2016) Christos E. Zois et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Targeting glycogen metabolism in bladder cancer

(2015) Carolyn Ritterson Lew et al.   Nature Reviews Urology

Glycogen metabolism in cancer

(2014) Christos E. Zois et al.   BIOCHEMICAL PHARMACOLOGY

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

(2014) J. Chen et al.   CANCER RESEARCH

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-  deficiency

(2014) R. Resaz et al.   Disease Models & Mechanisms

Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

(2014) X. Hong et al.   EMBO JOURNAL

Signalosome assembly by domains undergoing dynamic head-to-tail polymerization

(2014) Mariann Bienz   TRENDS IN BIOCHEMICAL SCIENCES

The 3T3-L1 adipocyte glycogen proteome

(2013) David Stapleton et al.   Proteome Science

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

Glycogen and its metabolism: some new developments and old themes

(2012) Peter J. Roach et al.   BIOCHEMICAL JOURNAL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress

(2012) Kwai Wa Cheng et al.   EMBO Molecular Medicine

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

(2012) Joffrey Pelletier et al.   Frontiers in Oncology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Treatment of kidney cancer

(2010) William G. Kaelin   CANCER

Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia

(2010) Guo-Min Shen et al.   FEBS LETTERS

Starch Binding Domain-containing Protein 1/Genethonin 1 Is a Novel Participant in Glycogen Metabolism

(2010) Sixin Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Depletion of the Malin E3 Ubiquitin Ligase in Mice Leads to Lafora Bodies and the Accumulation of Insoluble Laforin

(2010) Anna A. DePaoli-Roach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas

(2010) Elodie Mutel et al.   JOURNAL OF HEPATOLOGY

Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy

(2010) Janice Y. Chou et al.   Nature Reviews Endocrinology

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

(2010) S Whittaker et al.   ONCOGENE

Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

(2010) Nuria Pescador et al.   PLoS One

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of hepatic glycogen-associated proteins

(2010) David Stapleton et al.   PROTEOMICS

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

(2009) Andrew McBride et al.   Cell Metabolism

Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-13C6]-d-glucose tracer in mice

(2009) Richard D. Beger et al.   Metabolomics

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE