Structural basis and regulation of the reductive stress response

Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase

(2021) Xinyan Chen et al.   Nature Chemical Biology

Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron

(2021) Xiaojie Yan et al.   Nature Chemical Biology

Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion

(2021) Fernando Rodríguez-Pérez et al.   DEVELOPMENTAL CELL

Reductive stress impairs myogenic differentiation

(2020) Namakkal S. Rajasekaran et al.   Redox Biology

Mitochondria as intracellular signaling platforms in health and disease

(2020) Jay X. Tan et al.   JOURNAL OF CELL BIOLOGY

Structure and dynamics of the ASB9 CUL-RING E3 Ligase

(2020) Ryan J. Lumpkin et al.   Nature Communications

Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in Folliculin Interacting Protein 1 deficiency

(2020) Francesco Saettini et al.   BLOOD

A Cellular Mechanism to Detect and Alleviate Reductive Stress

(2020) Andrew G. Manford et al.   CELL

Galvanization of Protein–Protein Interactions in a Dynamic Zinc Interactome

(2020) Anna Kocyła et al.   TRENDS IN BIOCHEMICAL SCIENCES

BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma

(2020) Keiichi Tamai et al.   Scientific Reports

Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells

(2019) Luena Papa et al.   Stem Cells International

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

(2019) Kyle R. Simonetta et al.   Nature Communications

Variant recurrence in neurodevelopmental disorders: the use of publicly available genomic data identifies clinically relevant pathogenic missense variants

(2019) François Lecoquierre et al.   GENETICS IN MEDICINE

Xq22 deletions and correlation with distinct neurological disease traits in females: further evidence for a contiguous gene syndrome

(2019) Hadia Hijazi et al.   HUMAN MUTATION

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons

(2018) Itay Koren et al.   CELL

“Keaping” a lid on lung cancer: the Keap1-Nrf2 pathway

(2018) Sarah A. Best et al.   CELL CYCLE

Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming

(2018) Benjamin A. Schwarz et al.   Cell Stem Cell

Protein kinase C: perfectly balanced

(2018) Alexandra C. Newton   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mitochondria and the dynamic control of stem cell homeostasis

(2018) Pawel Lisowski et al.   EMBO REPORTS

C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases

(2018) Hsiu-Chuan Lin et al.   MOLECULAR CELL

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems

(2018) Sung Ryul Lee   Oxidative Medicine and Cellular Longevity

Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs

(2018) Paul A. DaRosa et al.   PROTEIN SCIENCE

An introduction to experimental phasing of macromolecules illustrated by SHELX; new autotracing features

(2018) Isabel Usón et al.   Acta Crystallographica Section D-Structural Biology

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle

(2018) Steven D. Cappell et al.   NATURE

Dimerization quality control ensures neuronal development and survival

(2018) Elijah L. Mena et al.   SCIENCE

Structural insights into ankyrin repeat–mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion

(2017) Wenfei Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase

(2017) Raffaello Verardi et al.   STRUCTURE

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period

(2016) Mandi J. Corenblum et al.   AGING CELL

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

(2016) Georg Petzold et al.   NATURE

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation

(2014) Ira Schmalen et al.   CELL

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

(2014) Eric S. Fischer et al.   NATURE

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

(2013) Jun He et al.   MOLECULAR CELL

OptimizedE. coliexpression strain LOBSTR eliminates common contaminants from His-tag purification

(2013) Kasper R. Andersen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Automatic protein structure solution from weak X-ray data

(2013) Pavol Skubák et al.   Nature Communications

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development

(2012) M. Baba et al.   BLOOD

Ubiquitin-dependent regulation of COPII coat size and function

(2012) Lingyan Jin et al.   NATURE

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1

(2011) Janet L Burton et al.   EMBO JOURNAL

Multivariate phase combination improves automated crystallographic model building

(2010) Pavol Skubák et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Recent developments in classical density modification

(2010) Kevin Cowtan   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice

(2010) Namakkal Soorappan Rajasekaran et al.   ANTIOXIDANTS & REDOX SIGNALING

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA