Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146

(2017) Yoshinori Matsumoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase

(2017) Wenshu Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling

(2016) Hui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin

(2016) Craig I. Campbell et al.   JOURNAL OF CELL SCIENCE

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling

(2016) Laura Mariotti et al.   MOLECULAR CELL

Structural insights into SAM domain-mediated tankyrase oligomerization

(2016) Paul A. DaRosa et al.   PROTEIN SCIENCE

Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling

(2016) Amanda A. Riccio et al.   STRUCTURE

Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification

(2016) Travis Eisemann et al.   STRUCTURE

Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins

(2015) Wenqi Wang et al.   Cell Reports

Tankyrases: Structure, Function and Therapeutic Implications in Cancer

(2014) Teemu Haikarainen et al.   CURRENT PHARMACEUTICAL DESIGN

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

(2014) Nan Li et al.   GENES & DEVELOPMENT

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

(2014) Paul A. DaRosa et al.   NATURE

Tankyrases as drug targets

(2013) Lari Lehtiö et al.   FEBS Journal

The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation

(2012) Hui-Ling Guo et al.   CELL RESEARCH

Tankyrase 1 regulates centrosome function by controlling CPAP stability

(2012) Mi Kyung Kim et al.   EMBO REPORTS

Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination

(2012) Z. Wang et al.   GENES & DEVELOPMENT

GDP-Mannose-4,6-Dehydratase Is a Cytosolic Partner of Tankyrase 1 That Inhibits Its Poly(ADP-Ribose) Polymerase Activity

(2012) K. K. Bisht et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation

(2012) Yuko Ozaki et al.   MOLECULAR CELL

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

(2012) S. Morrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism

(2011) Noam Levaot et al.   CELL

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

(2011) Sebastian Guettler et al.   CELL

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE