Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone

A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence

(2021) Beatriz Lozano-Torres et al.   ANALYTICAL CHEMISTRY

Very long chain fatty acid metabolism is required in acute myeloid leukemia

(2021) Matthew Tcheng et al.   BLOOD

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

(2021) Anthony Lagnado et al.   EMBO JOURNAL

Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs

(2021) Yusuke Kono et al.   Pharmaceutics

Autophagy drives fibroblast senescence through MTORC2 regulation

(2020) Monique Bernard et al.   Autophagy

Wild-type IDH2 contributes to Epstein-Barr virus -dependent metabolic alterations and tumorigenesis

(2020) Feng Shi et al.   Molecular Metabolism

The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative

(2020) Lei Gao et al.   Cancers

Autophagy Participates in Lysosomal Vacuolation-Mediated Cell Death in RGNNV-Infected Cells

(2020) Youhua Huang et al.   Frontiers in Microbiology

Mitochondrial ubiquinol oxidation is necessary for tumour growth

(2020) Inmaculada Martínez-Reyes et al.   NATURE

β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma

(2019) Guangya Zhang et al.   Cell Death & Disease

LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation

(2019) Qi Huang et al.   CANCER LETTERS

A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma

(2019) Luca Montemurro et al.   CANCER RESEARCH

Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization

(2019) Marta Pérez-Hernández et al.   Cancers

NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

(2018) Wusheng Xiao et al.   ANTIOXIDANTS & REDOX SIGNALING

A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia

(2018) Amy Y. Wang et al.   Journal of Hematology & Oncology

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis

(2018) Jung Hyun Park et al.   Redox Biology

Metabolic Plasticity of Tumor Cell Mitochondria

(2018) Giuseppe Cannino et al.   Frontiers in Oncology

The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death

(2018) Maciej Kaliszczak et al.   BRITISH JOURNAL OF CANCER

Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer

(2018) Alexandra Leary et al.   INVESTIGATIONAL NEW DRUGS

Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels

(2018) Nian Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Vaccination With Mitoxantrone-Treated Primary Colon Cancer Cells Enhances Tumor-Infiltrating Lymphocytes and Clinical Responses in Colorectal Liver Metastases

(2018) Jianzhong Qin et al.   JOURNAL OF SURGICAL RESEARCH

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

(2018) Matilda Lee et al.   Redox Biology

Design, Synthesis, and Biological Evaluation of Mitochondria-Targeted Flavone–Naphthalimide–Polyamine Conjugates with Antimetastatic Activity

(2017) Fujun Dai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

(2017) Jason Karch et al.   eLife

IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function

(2016) Jung-Bum Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

(2015) Dania C. Liemburg-Apers et al.   ARCHIVES OF TOXICOLOGY

A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak·Bcl-xl Complex and Triggering Transcriptional Regulation

(2015) Guohai Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria-Immobilized pH-Sensitive Off–On Fluorescent Probe

(2014) Min Hee Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MiR-487a resensitizes mitoxantrone (MX)-resistant breast cancer cells (MCF-7/MX) to MX by targeting breast cancer resistance protein (BCRP/ABCG2)

(2013) Meng-Tao Ma et al.   CANCER LETTERS

Reactive oxygen species generated in different compartments induce cell death, survival, or senescence

(2013) Emiliano Panieri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting cancer cell mitochondria as a therapeutic approach

(2012) Shijun Wen et al.   Future Medicinal Chemistry

Mitoxantrone Inhibits HIF-1  Expression in a Topoisomerase II-Independent Pathway

(2011) Y.-M. Toh et al.   CLINICAL CANCER RESEARCH

Stress-Responsive Sestrins Link p53 with Redox Regulation and Mammalian Target of Rapamycin Signaling

(2010) Andrei V. Budanov   ANTIOXIDANTS & REDOX SIGNALING

B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation

(2010) Xin Liang et al.   INVESTIGATIONAL NEW DRUGS

The role of mitochondrial complex III in melatonin-induced ROS production in cultured mesangial cells

(2010) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic strategies by modulating oxygen stress in cancer and inflammation

(2009) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Naphthalimides and Azonafides as Promising Anti-Cancer Agents

(2009) Laurent Ingrassia et al.   CURRENT MEDICINAL CHEMISTRY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY